Search Results - "He, Yungui"

Determinants of trafficking, conduction, and disease within a K + channel revealed through multiparametric deep mutational scanning by Coyote-Maestas, Willow, Nedrud, David, He, Yungui, Schmidt, Daniel

“…A long-standing goal in protein science and clinical genetics is to develop quantitative models of sequence, structure, and function relationships to…”
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Domain insertion permissibility-guided engineering of allostery in ion channels by Coyote-Maestas, Willow, He, Yungui, Myers, Chad L., Schmidt, Daniel

“…Allostery is a fundamental principle of protein regulation that remains hard to engineer, particularly in membrane proteins such as ion channels. Here we use…”
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Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling by Coyote-Maestas, Willow, Nedrud, David, Suma, Antonio, He, Yungui, Matreyek, Kenneth A., Fowler, Douglas M., Carnevale, Vincenzo, Myers, Chad L., Schmidt, Daniel

“…Protein domains are the basic units of protein structure and function. Comparative analysis of genomes and proteomes showed that domain recombination is a main…”
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Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin by Perissinotti, Paula P., Martínez-Hernández, Elizabeth, He, Yungui, Koob, Michael D., Piedras-Rentería, Erika S.

“…Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium…”
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KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain by Martínez-Hernández, Elizabeth, Zeglin, Alissa, Almazan, Erik, Perissinotti, Paula, He, Yungui, Koob, Michael, Martin, Jody L., Piedras-Rentería, Erika S.

“…Dorsal root ganglion (DRG) neurons process pain signaling through specialized nociceptors located in their peripheral endings. It has long been established low…”
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Comprehensive Domain Insertion Profiling to Study Inward Rectifier K+ Channel Folding Robustness by Coyote-Maestas, Willow, Nedrud, David, He, Yungui, Schmidt, Daniel

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Targeted insertional mutagenesis libraries for deep domain insertion profiling by Coyote-Maestas, Willow, Nedrud, David, Okorafor, Steffan, He, Yungui, Schmidt, Daniel

“…Abstract Domain recombination is a key principle in protein evolution and protein engineering, but inserting a donor domain into every position of a target…”
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Determinants of trafficking, conduction, and disease within a K.sup.+ channel revealed through multiparametric deep mutational scanning by Coyote-Maestas, Willow, Nedrud, David, He, Yungui, Schmidt, Daniel

“…A long-standing goal in protein science and clinical genetics is to develop quantitative models of sequence, structure, and function relationships to…”
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Deconvoluting receptor trafficking, regulation, and function using massively parallel assays by Nedrud, David, He, Yungui, Schmidt, Daniel, Fraser, James, Coyote-Maestas, Willow

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Differential Domain Insertion Permissibility is a Measure of Engineerable Allosteric Capacity in Ion Channels by Coyote-Maestas, Willow, He, Yungui, Myers, Chad, Schmidt, Daniel

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Targeted insertional mutagenesis libraries for deep domain insertion profiling by Coyote-Maestas, Willow, Nedrud, David, Okorafor, Steffan, He, Yungui, Schmidt, Daniel

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Programmable Assembly of Adeno-Associated Virus–Antibody Composites for Receptor-Mediated Gene Delivery by Zdechlik, Alina C, He, Yungui, Aird, Eric J, Gordon, Wendy R, Schmidt, Daniel

“…Adeno-associated virus (AAV) has emerged as a viral gene delivery vector that is safe in humans, able to infect both dividing and arrested cells and drive…”
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Multiparametric domain insertional profiling of adeno-associated virus VP1 by Hoffmann, Mareike D., Zdechlik, Alina C., He, Yungui, Nedrud, David, Aslanidi, George, Gordon, Wendy, Schmidt, Daniel

“…Several evolved properties of adeno-associated virus (AAV), such as broad tropism and immunogenicity in humans, are barriers to AAV-based gene therapy. Most…”
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Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation by Mische, Sarah, He, Yungui, Ma, Lingzhi, Li, Mingang, Serr, Madeline, Hays, Thomas S

“…The dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully…”
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Kinesin-5 Mediated Chromosome Congression in Insect Spindles by Tubman, Emily, He, Yungui, Hays, Thomas S., Odde, David J.

“…Introduction The microtubule motor protein kinesin-5 is well known to establish the bipolar spindle by outward sliding of antiparallel interpolar microtubules…”
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KLHL1 Controls Ca V 3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain by Martínez-Hernández, Elizabeth, Zeglin, Alissa, Almazan, Erik, Perissinotti, Paula, He, Yungui, Koob, Michael, Martin, Jody L, Piedras-Rentería, Erika S

“…Dorsal root ganglion (DRG) neurons process pain signaling through specialized nociceptors located in their peripheral endings. It has long been established low…”
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A novel locus for autosomal dominant nonsyndromic hearing loss identified at 5q31.1-32 in a Chinese pedigree by Xia, Jiahui, Deng, Hao, Feng, Yong, Zhang, Huali, Pan, Qian, Dai, Heping, Long, Zhigao, Tang, Beisha, Deng, Hanxiang, Chen, Yong, Zhang, Ruifang, Zheng, Duo, He, Yungui, Xia, Kun

“…Hearing impairment is an extremely heterogeneous disorder. A total of 35 loci and 17 related genes for autosomal dominant nonsyndromic hearing loss have been…”
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Genetic Ablation of KLHL1 Alters CaV3.2 Expression in DRG Neurons and Mechanical Pain Transmission by Martinez-Hernandez, Elizabeth, He, Yungui, Perissinotti, Paula P., Almazan, Erik, Koobb, Michael D., Piedras-Renteria, Erika S.

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The Kelch‐Like 1 Actin Binding Protein Modulates Neuronal Voltage Gated Calcium Channels by Piedras‐Renteria, Erika Sofia, Perissinotti, Paula Patricia, Ethington, Elizabeth Gibbs, He, Yungui, Martin, Jody, Cribbs, Leanne, Koob, Michael D

“…Abstract only Kelch‐like 1 (KLHL1) is a neuronal actin‐binding protein first identified in humans as part of the genetic locus of the neurological movement…”
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Targeted Deletion of a Single Sca8 Ataxia Locus Allele in Mice Causes Abnormal Gait, Progressive Loss of Motor Coordination, and Purkinje Cell Dendritic Deficits by He, Yungui, Zu, Tao, Benzow, Kellie A, Orr, Harry T, Clark, H. Brent, Koob, Michael D

“…Spinocerebellar ataxia type 8 (SCA8) patients typically have a slowly progressive, adult-onset ataxia. SCA8 is dominantly inherited and is caused by large CTG…”
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