Search Results - "He, Yuanjun"

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation by Choi, Jang Hyun, Banks, Alexander S., Kamenecka, Theodore M., Busby, Scott A., Chalmers, Michael J., Kumar, Naresh, Kuruvilla, Dana S., Shin, Youseung, He, Yuanjun, Bruning, John B., Marciano, David P., Cameron, Michael D., Laznik, Dina, Jurczak, Michael J., Schürer, Stephan C., Vidović, Dušica, Shulman, Gerald I., Spiegelman, Bruce M., Griffin, Patrick R.

“…Towards better antidiabetic drugs The nuclear receptor PPARγ is the target of thiazolidinedione antidiabetics including rosiglitazone and pioglitazone. These…”
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Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity by Guo, Yajing, Lu, Qiongqiong, Yang, Xiao-Jun, He, Yuxi, Wu, Yue, Qin, Baijun, Li, Ting, Duan, Min, Liu, Nvping, Wu, Xin, He, Yuanjun

“…To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing…”
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A New Approach to Analyzing Interactions of Two Objects in Space Based on a Specially- Tailored Local Coordinate System by Yu, Haiyan, He, Yuanjun, Zhang, Wenjun

“…Conventionally, geometric computing problems are treated as algebraic computing problems by representing a geometric object in a global reference coordinate…”
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HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists by Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R

“…Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to…”
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Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways by Li, Xiaohai, He, Yuanjun, Ruiz, Claudia H, Koenig, Marcel, Cameron, Michael D, Vojkovsky, Tomas

“…Dasatinib was approved in 2006 for the treatment of imatinib-resistant chronic myelogenous leukemia and functions primarily through the inhibition of BCR-ABL…”
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Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists by Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R

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Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction by Lepore, Salvatore D, He, Yuanjun

“…A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high…”
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REV-ERBα Regulates TH17 Cell Development and Autoimmunity by Amir, Mohammed, Chaudhari, Sweena, Wang, Ran, Campbell, Sean, Mosure, Sarah A., Chopp, Laura B., Lu, Qun, Shang, Jinsai, Pelletier, Oliver B., He, Yuanjun, Doebelin, Christelle, Cameron, Michael D., Kojetin, Douglas J., Kamenecka, Theodore M., Solt, Laura A.

“…RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH17) cell development. However, the cell-intrinsic mechanisms that…”
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Representation and retrieval of 3D CAD models in parts library by Wei, Liu, Yuanjun, He

“…In this paper a novel method of representation and retrieval of 3D CAD models in part libraries is presented with the aim being to facilitate the reuse of…”
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Low-gravity liquid nonlinear sloshing analysis in a tank under pitching excitation by Yuanjun, He, Xingrui, Ma, Pingping, Wang, Benli, Wang

“…Under pitch excitation, the sloshing of liquid in circular cylindrical tank includes planar motion, rotary motion and rotary motion inside planar motion. The…”
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Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α by Doebelin, Christelle, He, Yuanjun, Campbell, Sean, Nuhant, Philippe, Kumar, Naresh, Koenig, Marcel, Garcia-Ordonez, Ruben, Chang, Mi Ra, Roush, William R, Lin, Li, Kahn, Susan, Cameron, Michael D, Griffin, Patrick R, Solt, Laura A, Kamenecka, Theodore M

“…Despite a massive industry endeavor to develop RORγ-modulators for autoimmune disorders, there has been no indication of efforts to target the close family…”
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Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα by Shin, Youseung, Noel, Romain, Banerjee, Subhashis, Kojetin, Douglas, Song, Xinyi, He, Yuanjun, Lin, Li, Cameron, Michael D., Burris, Thomas P., Kamenecka, Theodore M.

“…The synthesis and optimization of a series of small molecule Rev-erbα agonists is described. Compounds with good cell-based potency and efficacy and good mouse…”
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Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors by He, Yuanjun, Kamenecka, Theodore M., Shin, Youseung, Song, Xinyi, Jiang, Rong, Noel, Romain, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Cameron, Michael D., Lin, Li, Khan, Susan, Koenig, Marcel, LoGrasso, Philip V.

“…Quinazolines 3 and 13a were discovered as novel c-jun N-terminal kinase (JNK) inhibitors with good brain penetration and pharmacokinetic (PK) properties…”
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Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors by Noël, Romain, Shin, Youseung, Song, Xinyi, He, Yuanjun, Koenig, Marcel, Chen, Weimin, Ling, Yuan Yuan, Lin, Li, Ruiz, Claudia H., LoGrasso, Phil, Cameron, Michael D., Duckett, Derek R., Kamenecka, Theodore M.

“…The design and synthesis of a novel series of c-jun N-terminal kinase (JNK) inhibitors is described. The development of the 4-(pyrazol-3-yl)-pyridine series…”
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Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors by Shin, Youseung, Chen, Weiming, Habel, Jeff, Duckett, Derek, Ling, Yuan Yuan, Koenig, Marcel, He, Yuanjun, Vojkovsky, Tomas, LoGrasso, Philip, Kamenecka, Theodore M.

“…A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from high-throughput-screening lead 1. A novel series of c-jun…”
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Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry by Chalmers, Michael J., Busby, Scott A., Pascal, Bruce D., He, Yuanjun, Hendrickson, Christopher L., Marshall, Alan G., Griffin, Patrick R.

“…Amide hydrogen/deuterium exchange is a powerful biophysical technique for probing changes in protein dynamics induced by ligand interaction. The inherent low…”
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Studies on the Base-Promoted Conversion of Conjugated Alkynyl Esters to α-Substituted α-Allenyl Esters by Lepore, Salvatore D, He, Yuanjun, Damisse, Pamela

“…We report the development of an efficient method for the conversion of a variety of conjugated alkynyl esters to α-substituted conjugated allenyl esters…”
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A Method for Content-Based Searching of 3D Model Databases by Wang, Jiale, Cai, Hongming, He, Yuanjun

“…With the development of computer graphics and digitalizing technologies, 3D model databases are becoming ubiquitous. This paper presents a method for…”
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3D Shape Similarity Comparison Using Multi-level Spherical Moments by Liu, Wei, He, Yuanjun

“…In this paper we present a novel method for shape comparison of 3D models that employs multilevel spherical moments analysis approach relying on voxelization…”
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Multigram-scale synthesis of enantiopure 3,3-difluoroproline by Doebelin, Christelle, He, Yuanjun, Kamenecka, Theodore M.

“…[Display omitted] •Enantioselective synthesis of 3,3-difluoroproline.•Short scalable synthesis.•Resolution provided both enantiomer in high ee and yield. An…”
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