Search Results - "He, Y A"

The role of oxidative stress in neuromelanin synthesis in PC12 cells by He, A.-Y, Qiu, L.-J, Gao, Y, Zhu, Y, Xu, Z.-W, Xu, J.-M, Zhang, Z.-H

“…Abstract Previous research has indicated that neuromelanin (NM) is involved in the pathogenesis of Parkinson's disease (PD). Increased reactive oxygen species…”
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Phenylalanine and Tryptophan Scanning Mutagenesis of CYP3A4 Substrate Recognition Site Residues and Effect on Substrate Oxidation and Cooperativity by Domanski, Tammy L, He, You-Ai, Khan, Kishore K, Roussel, Fabienne, Wang, Qinmi, Halpert, James R

“…Phenylalanine and/or tryptophan scanning mutagenesis was performed at 15 sites within CYP3A4 proposed to be involved in substrate specificity or cooperativity…”
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Length-weight relationships of nine freshwater fish species from the Liujiang River, Guangxi, China by He, A. Y., Xiu, L. H., Yang, J.

“…Summary Studied were the length–weight relationships (LWRs) of 599 fish specimens covering four families, nine genera and nine species (Sinibrama macrops,…”
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Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase by Halpert, J R, He, Y A

“…Six site-directed mutants of cytochrome P450 2B1 were constructed, and function was evaluated in COS cell microsomes by monitoring testosterone and…”
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Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity by Domanski, T L, He, Y A, Harlow, G R, Halpert, J R

“…The structural basis of cooperativity of progesterone hydroxylation catalyzed by human cytochrome P450 3A4 has been investigated. A recent study suggested that…”
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Molecular basis for a functionally unique cytochrome P450IIB1 variant by Kedzie, K M, Balfour, C A, Escobar, G Y, Grimm, S W, He, Y A, Pepperl, D J, Regan, J W, Stevens, J C, Halpert, J R

“…Liver microsomes from phenobarbital-treated rats of four inbred strains expressing distinct allelic variants of cytochrome P450IIB1 were analyzed. The Wistar…”
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Identification and functional characterization of eight CYP3A4 protein variants by EISELT, Regina, DOMANSKI, Tammy L, KHAN, Kishore K, HE, You-Ai, HALPERT, James R, WOJNOWSKI, Leszek, ZIBAT, Arne, MUELLER, Romy, PRESECAN-SIEDEL, Elena, HUSTERT, Elisabeth, ZANGER, Ulrich M, BROCKMOLLER, Jürgen, KLENK, Hans-Peter, MEYER, Urs A

“…The genetic component of the inter-individual variability in CYP3A4 activity has been estimated to be between 60% and 90%, but the underlying genetic factors…”
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Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance by Chen, Ping, Lee, Nathan V, Hu, Wenyue, Xu, Meirong, Ferre, Rose Ann, Lam, Hieu, Bergqvist, Simon, Solowiej, James, Diehl, Wade, He, You-Ai, Yu, Xiu, Nagata, Asako, VanArsdale, Todd, Murray, Brion W

“…Therapeutically targeting aberrant intracellular kinase signaling is attractive from a biological perspective but drug development is often hindered by…”
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Identification of Three Key Residues in Substrate Recognition Site 5 of Human Cytochrome P450 3A4 by Cassette and Site-Directed Mutagenesis by He, You Ai, He, You Qun, Szklarz, Grazyna D, Halpert, James R

“…Cassette mutagenesis and site-directed mutagenesis were used to investigate the importance of individual amino acid residues at positions 364−377 of cytochrome…”
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Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1 by He, You Ai, Balfour, Celia A, Kedzie, Karen M, Halpert, James R

“…Two allelic variants and eight site-directed mutants of cytochrome P450 2B1 differing at residue 478 have been expressed in COS cells and assayed for…”
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Precise detection of water surface through the analysis of a single green waveform from bathymetry LiDAR by Tao, Bangyi, Li, Jizhe, Guo, Wei, He, Yan, Li, Youzhi, Huang, Haiqing, Yu, Jiayong, Mao, Zhihua

“…Determination of the correct water surface height (WSH) from green laser (532 nm) echoes alone in bathymetry LiDAR is challenging, as the green laser return…”
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Factors associated with the age of natural menopause and menopausal symptoms in Chinese women by Li, Lin, Wu, Jie, Pu, Danhua, Zhao, Yang, Wan, Chunhua, Sun, Lihua, Shen, Cai-e, Sun, Weihua, Yuan, Zhimin, Shen, Qin, He, Xiaoyan, Jiang, Jian, Luo, Naimei, He, Ya, Qian, Qiuju, Cai, Peiqin, Zhang, Mei

“…Abstract Objective To investigate the factors associated with the age of natural menopause and menopausal symptoms in a large population of Chinese middle-aged…”
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Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity by Hasler, J A, Harlow, G R, Szklarz, G D, John, G H, Kedzie, K M, Burnett, V L, He, Y A, Kaminsky, L S, Halpert, J R

“…Eleven amino acid residues unique to dog cytochrome P450 (P450) 2B11, compared with rat 2B1 and 2B2, rabbit 2B4 and 2B5, and mouse 2B10, in the putative…”
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Sonophotocatalytic degradation of methyl orange by nano-sized Ag/TiO2 particles in aqueous solutions by Wang, Hongyuan, Niu, Junfeng, Long, Xingxing, He, Ya

“…Sonophotocatalytic behaviour of methyl orange (MeO) in aqueous solution illuminated by light generated by a xenon lamp was investigated. For all three kinds of…”
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Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation by He, K, He, Y A, Szklarz, G D, Halpert, J R, Correia, M A

“…Secobarbital (SB) is a relatively selective mechanism-based inactivator of cytochrome P450 2B1, that partitions between epoxidation and heme and protein…”
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Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1 by Szklarz, Grazyna D, He, You Ai, Halpert, James R

“…Prompted by our previous homology model of cytochrome P450 2B1 based on the 3-D structure of P450cam [Szklarz, G. D., Ornstein, R. L., & Halpert, J. R. (1994)…”
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A Chinese familial growth hormone deficiency with a deletion of 7.1 kb of DNA by He, Y A, Chen, S S, Wang, Y X, Lin, X Y, Wang, D F

“…Using restriction endonuclease analysis and a human growth hormone cDNA probe, we have found a Chinese family with a human growth hormone gene deletion. Two…”
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Role of Residue 480 in Substrate Specificity of Cytochrome P450 2B5 and 2B11 by Liu, Juping, He, You Ai, Halpert, James R.

“…The role of residue 480 as a determinant of the specificities of cytochrome P450 2B5 and 2B11 toward androstenedione, progesterone,…”
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Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5 by John, G H, Hasler, J A, He, Y A, Halpert, J R

“…Dog CYP2B11, rat CYP2B1, and rabbit CYP2B5 have been expressed in Escherichia coli from cDNAs modified at the N-terminus (Barnes et al., 1991, Proc. Natl…”
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Functional bacteria as potential indicators of water quality in Three Gorges Reservoir, China by Wang, Hongyuan, Shen, Zhenyao, Niu, Junfeng, He, Ya, Hong, Qian, Wang, Ying

“…The distributions of culturable bacteria and functional bacteria associated with nitrogen (N) or phosphorus (P) in the backwater areas of the Three Gorges…”
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