Search Results - "He, Pingnian"

Leucocyte/endothelium interactions and microvessel permeability: coupled or uncoupled? by He, Pingnian

“…In response to infections or tissue injury, circulating leucocytes adhere to and migrate from the vessel lumen to interstitial inflammatory sites to combat…”
Get full text

Oxidative Stress and Microvessel Barrier Dysfunction by He, Pingnian, Talukder, M. A. Hassan, Gao, Feng

“…Clinical and experimental evidence indicate that increased vascular permeability contributes to many disease-associated vascular complications. Oxidative…”
Get full text

In vitro recapitulation of functional microvessels for the study of endothelial shear response, nitric oxide and [Ca2+]i by Li, Xiang, Xu, Sulei, He, Pingnian, Liu, Yuxin

“…Microfluidic technologies enable in vitro studies to closely simulate in vivo microvessel environment with complexity. Such method overcomes certain constrains…”
Get full text

Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke by Begum, Gulnaz, Song, Shanshan, Wang, Shaoxia, Zhao, Hanshu, Bhuiyan, Mohammad Iqbal H., Li, Eric, Nepomuceno, Rachel, Ye, Qing, Sun, Ming, Calderon, Michael Joseph, Stolz, Donna B., St. Croix, Claudette, Watkins, Simon C., Chen, Yinhuai, He, Pingnian, Shull, Gary E., Sun, Dandan

“…Stimulation of Na+/H+ exchanger isoform 1 (NHE1) in astrocytes causes ionic dysregulation under ischemic conditions. In this study, we created a Nhe1flox/flox…”
Get full text

Vascular remodeling alters adhesion protein and cytoskeleton reactions to inflammatory stimuli resulting in enhanced permeability increases in rat venules by Yuan, Dong, He, Pingnian

“…Vascular remodeling has been implicated in many inflammation-involved diseases. This study aims to investigate the microvascular remodeling-associated…”
Get full text

Temporal and spatial correlation of platelet-activating factor-induced increases in endothelial [Ca²⁺]i, nitric oxide, and gap formation in intact venules by Zhou, Xueping, He, Pingnian

“…We have previously demonstrated that platelet-activating factor (PAF)-induced increases in microvessel permeability were associated with endothelial gap…”
Get more information

Endothelial [Ca2+]¡ and caveolin-1 antagonistically regulate eNOS activity and microvessel permeability in rat venules by XUEPING ZHOU, PINGNIAN HE

Get full text

Transendothelial movement of adiponectin is restricted by glucocorticoids by Dang, Thanh Q, Yoon, Nanyoung, Chasiotis, Helen, Dunford, Emily C, Feng, Qilong, He, Pingnian, Riddell, Michael C, Kelly, Scott P, Sweeney, Gary

“…Altered permeability of the endothelial barrier in a variety of tissues has implications both in disease pathogenesis and treatment. Glucocorticoids are potent…”
Get full text

H2O2‐induced microvessel barrier dysfunction: the interplay between reactive oxygen species, nitric oxide, and peroxynitrite by Zhou, Xueping, Qian, Yan, Yuan, Dong, Feng, Qilong, He, Pingnian

“…Elevated H2O2 is implicated in many cardiovascular diseases. We previously demonstrated that H2O2‐induced endothelial nitric oxide synthase (eNOS) activation…”
Get full text

Reduction of Endothelial Nitric Oxide Increases the Adhesiveness of Constitutive Endothelial Membrane ICAM-1 through Src-Mediated Phosphorylation by Gao, Feng, Lucke-Wold, Brandon P, Li, Xiang, Logsdon, Aric F, Xu, Li-Chong, Xu, Sulei, LaPenna, Kyle B, Wang, Huaqi, Talukder, M A Hassan, Siedlecki, Christopher A, Huber, Jason D, Rosen, Charles L, He, Pingnian

“…Nitric oxide (NO) is a known anti-adhesive molecule that prevents platelet aggregation and leukocyte adhesion to endothelial cells (ECs). The mechanism has…”
Get full text

Dissecting the Molecular Control of Endothelial NO Synthase by Caveolin-1 Using Cell-Permeable Peptides by Bernatchez, Pascal N., Bauer, Philip M., Yu, Jun, Prendergast, Jay S., He, Pingnian, Sessa, William C., Ignarro, Louis J.

“…In endothelia, NO is synthesized by endothelial NO synthase (eNOS), which is negatively regulated by caveolin-1 (Cav-1), the primary coat protein of caveolae…”
Get full text

Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: role of activated endothelial cells by He, Pingnian, Zhang, Hong, Zhu, Longkun, Jiang, Yanyan, Zhou, Xueping

“…Leukocyte-platelet aggregation and aggregate adhesion have been indicated as biomarkers of the severity of tissue injury during inflammation or ischemic…”
Get more information

Insulin decreases atherosclerosis by inducing endothelin receptor B expression by Park, Kyoungmin, Mima, Akira, Li, Qian, Rask-Madsen, Christian, He, Pingnian, Mizutani, Koji, Katagiri, Sayaka, Maeda, Yasutaka, Wu, I-Hsien, Khamaisi, Mogher, Preil, Simone Rordam, Maddaloni, Ernesto, Sørensen, Ditte, Rasmussen, Lars Melholt, Huang, Paul L, King, George L

“…Endothelial cell (EC) insulin resistance and dysfunction, caused by diabetes, accelerates atherosclerosis. It is unknown whether specifically enhancing…”
Get full text

Assessing Endothelial Cell Permeability and Transport Pathways via Biotin/FITC‐Avidin Interaction in Cultured Endothelial Microchannel Networks Using Microfluidic Devices by Gao, Feng, He, Pingnian

“…Microfluidic technologies have enabled in vitro studies to closely simulate the in vivo microvessel environment with sufficient complexity. Our recent studies…”
Get full text

Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability by Zhu, Longkun, Schwegler-Berry, Diane, Castranova, Vince, He, Pingnian

“…We demonstrated previously that inhibition of endothelial nitric oxide synthase (NOS), using pharmacological inhibitors, attenuated the ionomycin- and…”
Get more information

Improved measurements of intracellular nitric oxide in intact microvessels using 4,5-diaminofluorescein diacetate by Zhou, Xueping, He, Pingnian

“…4,5-Diaminofluorescein diacetate (DAF-2 DA) has been widely used for the measurement of nitric oxide (NO) in living cells and tissues. We previously…”
Get more information

Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 in patients with diabetes by Sun, Haoyu, Du, Yong, Kumar, Rinki, Buchkovich, Nicholas, He, Pingnian

“…Patients with diabetes infected with COVID-19 have greater mortality than those without comorbidities, but the underlying mechanisms remain unknown. This study…”
Get more information

Leveraging avidin-biotin interaction to quantify permeability property of microvessels-on-a-chip networks by Gao, Feng, Sun, Haoyu, Li, Xiang, He, Pingnian

“…Microvessels-on-a-chip have enabled in vitro studies to closely simulate in vivo microvessel environment. However, assessing microvessel permeability, a…”
Get more information

Exercise Alleviates Atherosclerosis Progression through Regulation of Inflammatory Cytokines by Ramadas, Nirupama, Du, Yong, Sun, Haoyu, Uwase, Hope, He, Pingnian

“…Atherosclerosis is one of the leading causes of mortality accounting for 30% of deaths worldwide. It is a disease of multifactorial etiology exemplified by…”
Get full text

Red Blood Cell Released ATP Regulates Systemic Immune Response in Atherosclerosis by Sun, Haoyu, Zhang, Yunpei, Du, Yong, He, Pingnian

“…Our studies demonstrated that disturbed flow‐induced ATP release from red blood cells (RBCs) via pannexin 1 (Panx1) channels plays a significant role in…”
Get full text