Search Results - "He, Fenglei"

Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification by He, Fenglei, Soriano, Philippe

“…Craniosynostosis is a prevalent human birth defect characterized by premature fusion of calvarial bones. In this study, we show that tight regulation of…”
Get full text

A critical role for PDGFRα signaling in medial nasal process development by He, Fenglei, Soriano, Philippe

“…The primitive face is composed of neural crest cell (NCC) derived prominences. The medial nasal processes (MNP) give rise to the upper lip and vomeronasal…”
Get full text

Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways by Vasudevan, Harish N, Mazot, Pierre, He, Fenglei, Soriano, Philippe

“…Receptor tyrosine kinases (RTKs) signal through shared intracellular pathways yet mediate distinct outcomes across many cell types. To investigate the…”
Get full text

Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development by He, Fenglei, Xiong, Wei, Yu, Xueyan, Espinoza-Lewis, Ramon, Liu, Chao, Gu, Shuping, Nishita, Michiru, Suzuki, Kentaro, Yamada, Gen, Minami, Yasuhiro, Chen, Yiping

“…Tissue and molecular heterogeneities are present in the developing secondary palate along the anteroposterior (AP) axis in mice. Here, we show that Wnt5a and…”
Get full text

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5 by Espinoza-Lewis, Ramón A., Yu, Ling, He, Fenglei, Liu, Hongbing, Tang, Ruhang, Shi, Jiangli, Sun, Xiaoxiao, Martin, James F., Wang, Dazhi, Yang, Jing, Chen, YiPing

“…The pacemaker is composed of specialized cardiomyocytes located within the sinoatrial node (SAN), and is responsible for originating and regulating the heart…”
Get full text

Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis by He, Fenglei, Xiong, Wei, Wang, Ying, Matsui, Maiko, Yu, Xueyan, Chai, Yang, Klingensmith, John, Chen, YiPing

“…BMP signaling plays many important roles during organ development, including palatogenesis. Loss of BMP signaling leads to cleft palate formation. During…”
Get full text

Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation, Migration and Differentiation During Midbrain Development by Gahankari, Apurva, Dong, Chunmin, Bartoletti, Garrett, Galazo, Maria, He, Fenglei

“…Mutations in allele are implicated in multiple brain tumors, indicating a rigorous control of Rac1 activity is required for neural tissue normal development…”
Get full text

Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth by Lin, Minkui, Li, Lu, Liu, Chao, Liu, Hongbing, He, Fenglei, Yan, Fuhua, Zhang, Yanding, Chen, YiPing

“…Wnt/β‐catenin signaling is essential for tooth development beyond the bud stage, but little is known about the role of non‐canonical Wnt signaling in…”
Get full text

Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis by Hu, Bing, Lefort, Karine, Qiu, Wenying, Nguyen, Bach-Cuc, Rajaram, Renuga Devi, Castillo, Einar, He, Fenglei, Chen, Yiping, Angel, Peter, Brisken, Cathrin, Dotto, G Paolo

“…Epithelial-mesenchymal interactions are key to skin morphogenesis and homeostasis. We report that maintenance of the hair follicle keratinocyte cell fate is…”
Get full text

Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect by He, Fenglei, Hu, Xuefeng, Xiong, Wei, Li, Lu, Lin, Lisong, Shen, Bin, Yang, Ling, Gu, Shuping, Zhang, Yanding, Chen, YiPing

“…Congenital bony syngnathia, a rare but severe human birth defect, is characterized by bony fusion of the mandible to the maxilla. However, the genetic…”
Get full text

Hand2 is required in the epithelium for palatogenesis in mice by Xiong, Wei, He, Fenglei, Morikawa, Yuka, Yu, Xueyan, Zhang, Zunyi, Lan, Yu, Jiang, Rulang, Cserjesi, Peter, Chen, YiPing

“…The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in the development of multiple organs, including craniofacial organs. Mice…”
Get full text

Tissue interaction is required for glenoid fossa development during temporomandibular joint formation by Wang, Ying, Liu, Chao, Rohr, Joseph, Liu, Hongbing, He, Fenglei, Yu, Jian, Sun, Cheng, Li, Lu, Gu, Shuping, Chen, YiPing

“…The mammalian temporomandibular joint (TMJ) develops from two distinct mesenchymal condensations that grow toward each other and ossify through different…”
Get full text

Expression survey of genes critical for tooth development in the human embryonic tooth germ by Lin, Dahe, Huang, Yide, He, Fenglei, Gu, Shuping, Zhang, Guozhong, Chen, YiPing, Zhang, Yanding

“…In the developing murine tooth, the expression patterns of numerous regulatory genes have been examined and their roles have begun to be revealed. To unveil…”
Get full text

Polycomblike‐2‐deficient mice exhibit normal left–right asymmetry by Wang, Shusheng, He, Fenglei, Xiong, Wei, Gu, Shuping, Liu, Hongbin, Zhang, Tao, Yu, Xueyan, Chen, Yiping

“…Polycomb group (PcG) proteins are required for maintaining the repressed state of developmentally important genes such as homeotic genes. Polycomblike (Pcl), a…”
Get full text

Cerberus functions as a BMP agonist to synergistically induce nodal expression during left–right axis determination in the chick embryo by Yu, Xueyan, He, Fenglei, Zhang, Tao, Espinoza‐Lewis, Ramón A., Lin, Lisong, Yang, Jing, Chen, Yiping

“…Left‐sided expression of Nodal in the lateral plate mesoderm (LPM) during early embryogenesis is a crucial step in establishing the left–right (L–R) axis in…”
Get full text

Characterizing expression pattern of Six2Cre during mouse craniofacial development by Umar, Meenakshi, Dong, Chunmin, He, Fenglei

“…Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene…”
Get full text

Sox10ER(T2) CreER(T2) mice enable tracing of distinct neural crest cell populations by He, Fenglei, Soriano, Philippe

“…Neural crest cells play an important role in craniofacial morphogenesis and many other developmental processes. The formation of neural crest cells (NCCs) in…”
Get full text

Deregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification by He, Fenglei, Soriano, Philippe

“…Craniosynostosis is a prevalent human birth defect characterized by premature fusion of calvarial bones. In this study, we show that tight regulation of…”
Get full text

Pdgfra regulates multipotent cell differentiation towards chondrocytes via inhibiting Wnt9a/beta-catenin pathway during chondrocranial cartilage development by Bartoletti, Garrett, Dong, Chunmin, Umar, Meenakshi, He, Fenglei

“…The mammalian skull is composed of the calvarial bones and cartilages. Malformation of craniofacial cartilage has been identified in multiple human syndromes…”
Get full text

Pten regulates neural crest proliferation and differentiation during mouse craniofacial development by Yang, Tianfang, Moore, Matthew, He, Fenglei

“…Background: The phosphatase and tensin homolog deleted on chromosome TEN (Pten) is implicated in a broad range of developmental events and diseases. However,…”
Get full text