Search Results - "He, Clifford Jiajun"

Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state by He, Bo, Stoffel, Lauren, He, Clifford Jiajun, Cho, Kumsun, Li, Albert M., Jiang, Haowen, Flowers, Brittany M., Nguyen, Kha The, Wang, Kelly Wen, Zhao, Audrey Yixin, Zhou, Meng-Ning, Ferreira, Sofia, Attardi, Laura D., Ye, Jiangbin

“…As a highly heterogeneous tumor, pancreatic ductal adenocarcinoma (PDAC) exhibits non-uniform responses to therapies across subtypes. Overcoming therapeutic…”
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Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells by Jiang, Haowen, He, Clifford Jiajun, Li, Albert M, He, Bo, Li, Yang, Zhou, Meng-Ning, Ye, Jiangbin

“…When the electron transport chain (ETC) function is impaired, cancer cells rely on reductive carboxylation (RC) to convert α-ketoglutarate (αKG) to citrate for…”
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Abstract 3695: Mitochondrial uncoupling reverses reductive carboxylation in cancer by Jiang, Haowen, He, Clifford Jiajun, Li, Albert M., He, Bo, Li, Yang, Ye, Jiangbin

“…When electron transport chain (ETC) activity is inhibited upon hypoxia or when cultured in suspension, reductive carboxylation plays an essential role in…”
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Abstract 3905: Epigenetic primming reveals the central role of epigenetic state in the anti-tumor activity of vitamin D in pancreatic ductal adenocarcinoma by He, Bo, Stoffel, Lauren, He, Clifford Jiajun, Li, Albert Mao, Jiang, Haowen, Cho, Kumsun, Flowers, Brittany M., Ferreira, Sofia, Attardi, Laura D., Ye, Jiangbin

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, which is largely due to the intrinsic resistance to a broad spectrum of therapies. Vitamin D…”
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