Search Results - "He, Aiqing"

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice by Parks, Brian W., Nam, Elizabeth, Org, Elin, Kostem, Emrah, Norheim, Frode, Hui, Simon T., Pan, Calvin, Civelek, Mete, Rau, Christoph D., Bennett, Brian J., Mehrabian, Margarete, Ursell, Luke K., He, Aiqing, Castellani, Lawrence W., Zinker, Bradley, Kirby, Mark, Drake, Thomas A., Drevon, Christian A., Knight, Rob, Gargalovic, Peter, Kirchgessner, Todd, Eskin, Eleazar, Lusis, Aldons J.

“…Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS)…”
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Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits by Civelek, Mete, Wu, Ying, Pan, Calvin, Raulerson, Chelsea K., Ko, Arthur, He, Aiqing, Tilford, Charles, Saleem, Niyas K., Stančáková, Alena, Scott, Laura J., Fuchsberger, Christian, Stringham, Heather M., Jackson, Anne U., Narisu, Narisu, Chines, Peter S., Small, Kerrin S., Kuusisto, Johanna, Parks, Brian W., Pajukanta, Päivi, Kirchgessner, Todd, Collins, Francis S., Gargalovic, Peter S., Boehnke, Michael, Laakso, Markku, Mohlke, Karen L., Lusis, Aldons J.

“…Subcutaneous adipose tissue stores excess lipids and maintains energy balance. We performed expression quantitative trait locus (eQTL) analyses by using…”
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Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils by Kirchgessner, Todd G., Sleph, Paul, Ostrowski, Jacek, Lupisella, John, Ryan, Carol S., Liu, Xiaoqin, Fernando, Gayani, Grimm, Denise, Shipkova, Petia, Zhang, Rongan, Garcia, Ricardo, Zhu, Jun, He, Aiqing, Malone, Harold, Martin, Richard, Behnia, Kamelia, Wang, Zhaoqing, Barrett, Yu Chen, Garmise, Robert J., Yuan, Long, Zhang, Jane, Gandhi, Mohit D., Wastall, Philip, Li, Tong, Du, Shuyan, Salvador, Lisa, Mohan, Raju, Cantor, Glenn H., Kick, Ellen, Lee, John, Frost, Robert J.A.

“…The development of LXR agonists for the treatment of coronary artery disease has been challenged by undesirable properties in animal models. Here we show the…”
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A high-resolution association mapping panel for the dissection of complex traits in mice by Bennett, Brian J, Farber, Charles R, Orozco, Luz, Kang, Hyun Min, Ghazalpour, Anatole, Siemers, Nathan, Neubauer, Michael, Neuhaus, Isaac, Yordanova, Roumyana, Guan, Bo, Truong, Amy, Yang, Wen-pin, He, Aiqing, Kayne, Paul, Gargalovic, Peter, Kirchgessner, Todd, Pan, Calvin, Castellani, Lawrence W, Kostem, Emrah, Furlotte, Nicholas, Drake, Thomas A, Eskin, Eleazar, Lusis, Aldons J

“…Systems genetics relies on common genetic variants to elucidate biologic networks contributing to complex disease-related phenotypes. Mice are ideal model…”
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The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells by Gargalovic, Peter S, Gharavi, Nima M, Clark, Michael J, Pagnon, Joanne, Yang, Wen-Pin, He, Aiqing, Truong, Amy, Baruch-Oren, Tamar, Berliner, Judith A, Kirchgessner, Todd G, Lusis, Aldons J

“…OBJECTIVE—Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (oxPAPC) accumulates in atherosclerotic lesions and in vitro studies suggest that…”
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Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease by Wes, Paul D, Easton, Amy, Corradi, John, Barten, Donna M, Devidze, Nino, DeCarr, Lynn B, Truong, Amy, He, Aiqing, Barrezueta, Nestor X, Polson, Craig, Bourin, Clotilde, Flynn, Marianne E, Keenan, Stefanie, Lidge, Regina, Meredith, Jere, Natale, Joanne, Sankaranarayanan, Sethu, Cadelina, Greg W, Albright, Charlie F, Cacace, Angela M

“…Filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including Alzheimer's…”
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HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization by Herjan, Tomasz, Yao, Peng, Qian, Wen, Li, Xiao, Liu, Caini, Bulek, Katarzyna, Sun, Dongxu, Yang, Wen-Pin, Zhu, Jun, He, Aiqing, Carman, Julie A, Erzurum, Serpil C, Lipshitz, Howard D, Fox, Paul L, Hamilton, Thomas A, Li, Xiaoxia

“…IL-17, a major inflammatory cytokine plays a critical role in the pathogenesis of many autoimmune inflammatory diseases. In this study, we report a new…”
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Identification of Inflammatory Gene Modules Based on Variations of Human Endothelial Cell Responses to Oxidized Lipids by Gargalovic, Peter S., Imura, Minori, Zhang, Bin, Gharavi, Nima M., Clark, Michael J., Pagnon, Joanne, Yang, Wen-Pin, He, Aiqing, Truong, Amy, Patel, Shilpa, Nelson, Stanley F., Horvath, Steve, Berliner, Judith A., Kirchgessner, Todd G., Lusis, Aldons J.

“…Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies…”
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Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells by Romanoski, Casey E., Lee, Sangderk, Kim, Michelle J., Ingram-Drake, Leslie, Plaisier, Christopher L., Yordanova, Roumyana, Tilford, Charles, Guan, Bo, He, Aiqing, Gargalovic, Peter S., Kirchgessner, Todd G., Berliner, Judith A., Lusis, Aldons J.

“…Gene by environment (GxE) interactions are clearly important in many human diseases, but they have proven to be difficult to study on a molecular level. We…”
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Genetic regulation of mouse liver metabolite levels by Ghazalpour, Anatole, Bennett, Brian J, Shih, Diana, Che, Nam, Orozco, Luz, Pan, Calvin, Hagopian, Raffi, He, Aiqing, Kayne, Paul, Yang, Wen‐pin, Kirchgessner, Todd, Lusis, Aldons J

“…We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics,…”
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Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells by Qian, Yueming, Khattak, Sarwat F., Xing, Zizhuo, He, Aiqing, Kayne, Paul S., Qian, Nan-Xin, Pan, Shih-Hsie, Li, Zheng Jian

“…This study reports the effects of varying concentrations of copper sulfate on the metabolic and gene transcriptional profile of a recombinant Chinese hamster…”
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Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells by Qiu, Dike, Xu, Ke, Chung, Namjin, Robbins, Jennifer, Luo, Robert, Lawrence, Michael, He, Aiqing, Yu, Fei, Alt, Andrew, Miller, Michael M, Hangeland, Jon, Feder, John N, Seiffert, Dietmar, Arey, Brian J

“…Vascular endothelial cells are exposed to mechanical forces due to their presence at the interface between the vessel wall and flowing blood. The patterns of…”
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Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures by Shen, Duan, Kiehl, Thomas R., Khattak, Sarwat F., Li, Zheng Jian, He, Aiqing, Kayne, Paul S., Patel, Vishal, Neuhaus, Isaac M., Sharfstein, Susan T.

“…The rapidly expanding market for monoclonal antibody and Fc‐fusion‐protein therapeutics has increased interest in improving the productivity of mammalian cell…”
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11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice by García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A

“…Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid…”
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Transcriptional profiling reveals strict boundaries between hippocampal subregions by Zhao, Xinyu, Lein, Edward S., He, Aiqing, Smith, Stanley C., Aston, Christopher, Gage, Fred H.

“…The hippocampus consists of distinct anatomic regions that have been demonstrated to have different biological functions. To explore the molecular differences…”
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A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures by Jing, Ying, Qian, Yueming, Ghandi, Mahmoud, He, Aiqing, Borys, Michael C., Pan, Shih-Hsie, Li, Zheng Jian

“…Dexamethasone (DEX) was previously shown (Jing et al., Biotechnol Bioeng. 2010;107:488‐496) to play a dual role in increasing sialylation of recombinant…”
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Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities by Ji, Rui-Ru, de Silva, Heshani, Jin, Yisheng, Bruccoleri, Robert E, Cao, Jian, He, Aiqing, Huang, Wenjun, Kayne, Paul S, Neuhaus, Isaac M, Ott, Karl-Heinz, Penhallow, Becky, Cockett, Mark I, Neubauer, Michael G, Siemers, Nathan O, Ross-Macdonald, Petra

“…The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to…”
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Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions by Quan, Yong, Jin, Yisheng, Faria, Teresa N, Tilford, Charles A, He, Aiqing, Wall, Doris A, Smith, Ronald L, Vig, Balvinder S

“…The expression levels of genes involved in drug and nutrient absorption were evaluated in the Madin-Darby Canine Kidney (MDCK) in vitro drug absorption model…”
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Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors by Ross-Macdonald, Petra, de Silva, Heshani, Patel, Vishal, Truong, Amy, He, Aiqing, Neuhaus, Isaac, Tilford, Charles, Ji, RuiRu, Siemers, Nathan, Greer, Ann, Carboni, Joan, Gottardis, Marco, Menard, Krista, Lee, Frank, Dodier, Marco, Frennesson, David, Sampognaro, Anthony, Saulnier, Mark, Trainor, George, Vyas, Dolatrai, Zimmermann, Kurt, Wittman, Mark

“…Therapeutic development of a targeted agent involves a series of decisions over additional activities that may be ignored, eliminated or pursued. This paper…”
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Abstract 12733: The Effect of Mavacamten Treatment on Hemolysis Biomarkers in Patients With Obstructive Hypertrophic Cardiomyopathy in the EXPLORER-HCM Study by Wang, Zhaoqing, Anderson, Warren, Sehnert, Amy J, He, Aiqing, Kurio, Gregory, olivotto, iacopo, Schafer, Peter

“…Abstract only Introduction: In patients with obstructive hypertrophic cardiomyopathy (HCM), blood flow changes from left ventricular outflow tract (LVOT)…”
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