Search Results - "Hazra, Amrita B."

Methylations in vitamin B12 biosynthesis and catalysis by Mathur, Yamini, Hazra, Amrita B.

“…Vitamin B12 is an essential biomolecule that assists in the catalysis of methyl transfer and radical-based reactions in cellular metabolism. The structure of…”
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Double agent indole-3-acetic acid: mechanistic analysis of indole-3-acetaldehyde dehydrogenase AldA that synthesizes IAA, an auxin that aids bacterial virulence by Shah, Ateek, Mathur, Yamini, Hazra, Amrita B

“…The large diversity of organisms inhabiting various environmental niches on our planet are engaged in a lively exchange of biomolecules, including nutrients,…”
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Anaerobic biosynthesis of the lower ligand of vitamin B12 by Hazra, Amrita B., Han, Andrew W., Mehta, Angad P., Mok, Kenny C., Osadchiy, Vadim, Begley, Tadhg P., Taga, Michiko E.

“…Vitamin B12(cobalamin) is required by humans and other organisms for diverse metabolic processes, although only a subset of prokaryotes is capable of…”
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Drought Drives Spatial Variation in the Millet Root Microbiome by Simmons, Tuesday, Styer, Alexander B, Pierroz, Grady, Gonçalves, Antonio Pedro, Pasricha, Ramji, Hazra, Amrita B, Bubner, Patricia, Coleman-Derr, Devin

“…Efforts to boost crop yield and meet global food demands while striving to reach sustainability goals are hindered by the increasingly severe impacts of…”
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Efficient Chemical and Enzymatic Syntheses of FAD Nucleobase Analogues and Their Analysis as Enzyme Cofactors by Shah, Ateek, Kumar, Yashwant, Rohan, S., Hazra, Amrita B.

“…Flavin adenine dinucleotide (FAD) is an essential redox cofactor in cellular metabolism. The organic synthesis of FAD typically involves coupling flavin…”
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Exchange of Vitamin B 1 and Its Biosynthesis Intermediates Shapes the Composition of Synthetic Microbial Cocultures and Reveals Complexities of Nutrient Sharing by Sathe, Rupali R M, Paerl, Ryan W, Hazra, Amrita B

“…Microbial communities occupy diverse niches in nature, and community members routinely exchange a variety of nutrients among themselves. While large-scale…”
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CobT and BzaC catalyze the regiospecific activation and methylation of the 5-hydroxybenzimidazole lower ligand in anaerobic cobamide biosynthesis by Mathur, Yamini, Sreyas, Sheryl, Datar, Prathamesh M., Sathian, Manjima B., Hazra, Amrita B.

“…Vitamin B12 and other cobamides are essential cofactors required by many organisms and are synthesized by a subset of prokaryotes via distinct aerobic and…”
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Exchange of Vitamin B1 and Its Biosynthesis Intermediates Shapes the Composition of Synthetic Microbial Cocultures and Reveals Complexities of Nutrient Sharing by Sathe, Rupali R. M, Paerl, Ryan W, Hazra, Amrita B

“…Microbial communities occupy diverse niches in nature, and community members routinely exchange a variety of nutrients among themselves. While large-scale…”
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Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation by Bora, Prerona, Manna, Suman, Nair, Mrutyunjay A, Sathe, Rupali R. M, Singh, Shubham, Sreyas Adury, Venkata Sai, Gupta, Kavya, Mukherjee, Arnab, Saini, Deepak K, Kamat, Siddhesh S, Hazra, Amrita B, Chakrapani, Harinath

“…Persulfides and polysulfides, collectively known as the sulfane sulfur pool along with hydrogen sulfide (H 2 S), play a central role in cellular physiology and…”
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Unique Biochemical and Sequence Features Enable BluB To Destroy Flavin and Distinguish BluB from the Flavin Monooxygenase Superfamily by Hazra, Amrita B, Ballou, David P, Taga, Michiko E

“…Vitamin B12 (cobalamin) is an essential micronutrient for humans that is synthesized by only a subset of bacteria and archaea. The aerobic biosynthesis of…”
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Mechanisms of direct inhibition of the respiratory sulfate-reduction pathway by (per)chlorate and nitrate by Carlson, Hans K, Kuehl, Jennifer V, Hazra, Amrita B, Justice, Nicholas B, Stoeva, Magdalena K, Sczesnak, Andrew, Mullan, Mark R, Iavarone, Anthony T, Engelbrektson, Anna, Price, Morgan N, Deutschbauer, Adam M, Arkin, Adam P, Coates, John D

“…We investigated perchlorate (ClO 4 − ) and chlorate (ClO 3 − ) (collectively (per)chlorate) in comparison with nitrate as potential inhibitors of sulfide (H 2…”
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“Radical Dance” in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase by Chatterjee, Abhishek, Hazra, Amrita B, Abdelwahed, Sameh, Hilmey, David G, Begley, Tadhg P

“…Tricky things with ThiC: Hydroxymethylpyrimidine phosphate (HMP‐P) synthase (ThiC) catalyzes one of the most complex rearrangement reactions in primary…”
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Anaerobic 5‑Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis by Mehta, Angad P, Abdelwahed, Sameh H, Fenwick, Michael K, Hazra, Amrita B, Taga, Michiko E, Zhang, Yang, Ealick, Steven E, Begley, Tadhg P

“…Comparative genomics of the bacterial thiamin pyrimidine synthase (thiC) revealed a paralogue of thiC (bzaF) clustered with anaerobic vitamin B12 biosynthetic…”
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Regiospecific Formation of Cobamide Isomers Is Directed by CobT by Crofts, Terence S, Hazra, Amrita B, Tran, Jennifer LA, Sokolovskaya, Olga M, Osadchiy, Vadim, Ad, Omer, Pelton, Jeffrey, Bauer, Stefan, Taga, Michiko E

“…Cobamides, which include vitamin B12 (cobalamin), are a class of modified tetrapyrroles synthesized exclusively by prokaryotes that function as cofactors for…”
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Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity by Crofts, Terence S., Seth, Erica C., Hazra, Amrita B., Taga, Michiko E.

“…Cobamides are members of the vitamin B12 family of cofactors that function in a variety of metabolic processes and are synthesized only by prokaryotes…”
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A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase by Hazra, Amrita B, Han, Ying, Chatterjee, Abhishek, Zhang, Yang, Lai, Rung-Yi, Ealick, Steven E, Begley, Tadhg P

“…In many bacteria tenI is found clustered with genes involved in thiamin thiazole biosynthesis. However, while TenI shows high sequence similarity with thiamin…”
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Methylations in vitamin B 12 biosynthesis and catalysis by Mathur, Yamini, Hazra, Amrita B

“…Vitamin B is an essential biomolecule that assists in the catalysis of methyl transfer and radical-based reactions in cellular metabolism. The structure of B…”
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A "Radical Dance" in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase by Chatterjee, Abhishek, Hazra, Amrita B., Abdelwahed, Sameh, Hilmey, David G., Begley, Tadhg P.

“…Vertrackte Sache: Hydroxymethylpyrimidinphosphat‐Synthase (ThiC) katalysiert eine der komplexesten Umlagerungen im Primärstoffwechsel. Deuterierungsexperimente…”
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Anaerobic biosynthesis of the lower ligand of vitamin B 12 by Hazra, Amrita B., Han, Andrew W., Mehta, Angad P., Mok, Kenny C., Osadchiy, Vadim, Begley, Tadhg P., Taga, Michiko E.

“…Significance Vitamin B 12 is required by humans and a variety of other organisms for diverse metabolic processes, but is produced only by a subset of…”
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Analysis of Substrate Specificity in CobT Homologs Reveals Widespread Preference for DMB, the Lower Axial Ligand of Vitamin B12 by Hazra, Amrita B., Tran, Jennifer L.A., Crofts, Terence S., Taga, Michiko E.

“…Cobamides such as vitamin B12 (cobalamin) are produced exclusively by prokaryotes and used by many other organisms as cofactors for diverse metabolic…”
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