Search Results - "Hazlewood, Ralph"

Differential effects of angiotensin II type I receptor blockers on reducing intraocular pressure and TGFβ signaling in the mouse retina by Hazlewood, Ralph J, Chen, Qingxia, Clark, Frances K, Kuchtey, John, Kuchtey, Rachel W

“…Angiotensin II type 1 receptor blockers (ARBs) have been investigated for their neuroprotective and intraocular pressure (IOP) lowering effects in treating…”
Get full text

Telmisartan Reduces Axon Degeneration in Mice With Experimental Glaucoma by Hazlewood, Ralph J, Kuchtey, John, Wu, Hang-Jing, Kuchtey, Rachel W

“…The purpose of this study was to determine if treatment with telmisartan, an angiotensin II type 1 receptor blocker (ARB), protects against retinal ganglion…”
Get full text

Enlarged Optic Nerve Axons and Reduced Visual Function in Mice with Defective Microfibrils by Wu, Hang-Jing, Hazlewood, Ralph J, Kuchtey, John, Kuchtey, Rachel W

“…Glaucoma is a leading cause of irreversible vision loss due to retinal ganglion cell (RGC) degeneration that develops slowly with age. Elevated intraocular…”
Get full text

MMP19 expression in the human optic nerve by Chirco, Kathleen R, Hazlewood, Ralph J, Miller, Kathy, Workalemahu, Grefachew, Jampol, Lee M, Lesser, G Robert, Mullins, Robert F, Kuehn, Markus H, Fingert, John H

“…The defining feature of glaucoma is excavation of the optic nerve head; however, the mechanism of this loss of tissue is not well understood. We recently…”
Get full text

Heterozygous Triplication of Upstream Regulatory Sequences Leads to Dysregulation of Matrix Metalloproteinase 19 in Patients with Cavitary Optic Disc Anomaly by Hazlewood, Ralph J., Roos, Benjamin R., Solivan-Timpe, Frances, Honkanen, Robert A., Jampol, Lee M., Gieser, Stephen C., Meyer, Kacie J., Mullins, Robert F., Kuehn, Markus H., Scheetz, Todd E., Kwon, Young H., Alward, Wallace L.M., Stone, Edwin M., Fingert, John H.

“…ABSTRACT Patients with a congenital optic nerve disease, cavitary optic disc anomaly (CODA), are born with profound excavation of the optic nerve resembling…”
Get full text

Molecular genetics of optic nerve disease using patients with cavitary optic disc anomaly by Hazlewood, Ralph Jeremiah

“…Glaucoma is the second leading cause of irreversible blindness in the United States and is the leading cause of blindness in African Americans. Cupping or…”
Get full text

Differential effects of angiotensin II type I receptor blockers on reducing intraocular pressure and TGF[beta] signaling in the mouse retina by Hazlewood, Ralph J, Chen, Qingxia, Clark, Frances K, Kuchtey, John, Kuchtey, Rachel W

“…Purpose Angiotensin II type 1 receptor blockers (ARBs) have been investigated for their neuroprotective and intraocular pressure (IOP) lowering effects in…”
Get full text

A large meta-analysis identifies genes associated with anterior uveitis by Gelfman, Sahar, Moscati, Arden, Huergo, Santiago Mendez, Wang, Rujin, Rajagopal, Veera, Parikshak, Neelroop, Pounraja, Vijay Kumar, Chen, Esteban, Leblanc, Michelle, Hazlewood, Ralph, Freudenberg, Jan, Cooper, Blerta, Ligocki, Ann J., Miller, Charles G., Van Zyl, Tavé, Weyne, Jonathan, Romano, Carmelo, Sagdullaev, Botir, Melander, Olle, Baras, Aris, Stahl, Eli A., Coppola, Giovanni

“…Anterior Uveitis (AU) is the inflammation of the anterior part of the eye, the iris and ciliary body and is strongly associated with HLA-B*27 . We report AU…”
Get full text

Molecular genetics of optic nerve disease using patients with cavitary optic disc anomaly by Hazlewood, Ralph Jeremiah, II

“…Glaucoma is the second leading cause of irreversible blindness in the United States and is the leading cause of blindness in African Americans. Cupping or…”
Get full text