Search Results - "Hazlehurst, Lori"

The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance by Meads, Mark B, Hazlehurst, Lori A, Dalton, William S

“…The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells. These cells are supported by…”
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Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors by Chen, Wei-Chih, Hu, Gangqing, Hazlehurst, Lori A

“…The bone marrow microenvironment (BMM) provides input via production of cytokines, chemokines, extracellular matrixes in the context of lower oxygen levels…”
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The Role of TRPC1 in Modulating Cancer Progression by Elzamzamy, Osama M, Penner, Reinhold, Hazlehurst, Lori A

“…Calcium ions (Ca ) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression…”
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Targeting Intrinsic and Extrinsic Vulnerabilities for the Treatment of Multiple Myeloma by Anreddy, Nagaraju, Hazlehurst, Lori A.

“…ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder, clinically characterized by osteolytic lesions, immunodeficiency, and renal disease. Over…”
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Role of Calcium Homeostasis in Modulating EMT in Cancer by Jones, Clark A, Hazlehurst, Lori A

“…Calcium is essential for cells to perform numerous physiological processes. In cancer, the augmentation of calcium signaling supports the more proliferative…”
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Molecular Signatures of CB-6644 Inhibition of the RUVBL1/2 Complex in Multiple Myeloma by Yi, Weijun, Dziadowicz, Sebastian A, Mangano, Rachel S, Wang, Lei, McBee, Joseph, Frisch, Steven M, Hazlehurst, Lori A, Adjeroh, Donald A, Hu, Gangqing

“…Multiple myeloma is the second most hematological cancer. RUVBL1 and RUVBL2 form a subcomplex of many chromatin remodeling complexes implicated in cancer…”
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β1 Integrin Adhesion Enhances IL-6―Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation by SHAIN, Kenneth H, YARDE, Danielle N, MEADS, Mark B, MEI HUANG, JOVE, Richard, HAZLEHURST, Lori A, DALTON, William S

“…Abstract The bone marrow microenvironmental components interleukin (IL)-6 and fibronectin (FN) individually influence the proliferation and survival of…”
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Chloroquine reduces neutrophil extracellular trap (NET) formation through inhibition of peptidyl arginine deiminase 4 (PAD4) by Ivey, Abby D, Matthew Fagan, B, Murthy, Pranav, Lotze, Michael T, Zeh, Herbert J, Hazlehurst, Lori A, Geldenhuys, Werner J, Boone, Brian A

“…Abstract Neutrophil extracellular traps (NETs) occur when chromatin is decondensed and extruded from the cell, generating a web-like structure. NETs have been…”
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The bone marrow microenvironment as a sanctuary for minimal residual disease in CML by Nair, Rajesh R., Tolentino, Joel, Hazlehurst, Lori A.

“…Bcr-abl kinase inhibitors have provided proof of principal that targeted therapy holds great promise for the treatment of cancer. However, despite the success…”
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Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma by Hayes, Karen E., Batsomboon, Paratchata, Chen, Wei-Chih, Johnson, Brennan D., Becker, Andreas, Eschrich, Steven, Yang, Yan, Robart, Aaron R., Dudley, Gregory B., Geldenhuys, Werner J., Hazlehurst, Lori A.

“…[Display omitted] Multiple myeloma (MM) cells demonstrate high basal endoplasmic reticulum (ER) stress and are typically exquisitely sensitive to agents such…”
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Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling by Wang, Lei, Yi, Weijun, Ma, Li, Lecea, Emily, Hazlehurst, Lori A, Adjeroh, Donald A, Hu, Gangqing

“…Bone marrow mesenchymal stem cells (BM MSCs) play a tumor-supportive role in promoting drug resistance and disease relapse in multiple myeloma (MM). Recent…”
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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases by Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P, Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M, Cubitt, Christopher L, Gebhard, Anthony W, Hazlehurst, Lori A, Tash, Joseph S, Georg, Gunda I

“…Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development…”
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Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET by Newton, Ebenezer, Starcovic, Sarah A., Menze, Michael, Konkle, Mary E., Long, Timothy E., Hazlehurst, Lori A., Huber, Jason D., Robart, Aaron R., Geldenhuys, Werner J.

“…[Display omitted] MitoNEET belongs to the CDGSH Iron-Sulfur Domain (CISD)-gene family of proteins and is a [2Fe-2S] cluster-containing protein found on the…”
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Bone Marrow Stroma-Induced Transcriptome and Regulome Signatures of Multiple Myeloma by Dziadowicz, Sebastian A, Wang, Lei, Akhter, Halima, Aesoph, Drake, Sharma, Tulika, Adjeroh, Donald A, Hazlehurst, Lori A, Hu, Gangqing

“…Multiple myeloma (MM) is a hematological cancer with inevitable drug resistance. MM cells interacting with bone marrow stromal cells (BMSCs) undergo…”
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The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke by Saralkar, Pushkar, Mdzinarishvili, Alexander, Arsiwala, Tasneem A, Lee, Yoon-Kwang, Sullivan, Patrick G., Pinti, Mark V., Hollander, John M., Kelley, Eric E., Ren, Xuefang, Hu, Heng, Simpkins, James, Brown, Candice, Hazlehurst, Lori E., Huber, Jason D., Geldenhuys, Werner J.

“…Purpose Therapeutic strategies to treat ischemic stroke are limited due to the heterogeneity of cerebral ischemic injury and the mechanisms that contribute to…”
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Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance by Bewry, Nadine N, Nair, Rajesh R, Emmons, Michael F, Boulware, David, Pinilla-Ibarz, Javier, Hazlehurst, Lori A

“…Imatinib mesylate is a potent, molecularly targeted therapy against the oncogenic tyrosine kinase BCR-ABL. Although imatinib mesylate has considerable efficacy…”
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Emergence of Resistance to MTI-101 Selects for a MET Genotype and Phenotype in EGFR Driven PC-9 and PTEN Deleted H446 Lung Cancer Cell Lines by Jones, Clark, Dziadowicz, Sebastian, Suite, Samuel, Eby, Ashley, Chen, Wei-Chih, Hu, Gangqing, Hazlehurst, Lori A

“…MTI-101 is a first-in-class cyclic peptide that kills cells via calcium overload in a caspase-independent manner. Understanding biomarkers of response is…”
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Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma by Yarde, Danielle N, Oliveira, Vasco, Mathews, Linda, Wang, Xingyu, Villagra, Alejandro, Boulware, David, Shain, Kenneth H, Hazlehurst, Lori A, Alsina, Melissa, Chen, Dung-Tsa, Beg, Amer A, Dalton, William S

“…The Fanconi anemia/BRCA (FA/BRCA) DNA damage repair pathway plays a pivotal role in the cellular response to replicative stress induced by DNA alkylating…”
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MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma by Emmons, Michael F., Anreddy, Nagaraju, Cuevas, Javier, Steinberger, Kayla, Yang, Shengyu, McLaughlin, Mark, Silva, Ariosto, Hazlehurst, Lori A.

“…The emergence of drug resistance continues to be a major hurdle towards improving patient outcomes for the treatment of Multiple Myeloma. MTI-101 is a…”
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Human Multiple Myeloma Cells Are Sensitized to Topoisomerase II Inhibitors by CRM1 Inhibition by TURNER, Joel G, MARCHION, Douglas C, DAWSON, Jana L, EMMONS, Michael F, HAZLEHURST, Lori A, WASHAUSEN, Peter, SULLIVAN, Daniel M

“…Topoisomerase IIalpha (topo IIalpha) is exported from the nucleus of human myeloma cells by a CRM1-dependent mechanism at cellular densities similar to those…”
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