Search Results - "Hazemann, I."

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase by Hazemann, I., Blakeley, M. P., Dauvergne, M. T., Meilleur, F., Haertlein, M., Mitschler, A., Van Dorsselaer, A., Myles, D. A. A., Podjarny, A.

“…Neutron diffraction data have been collected to 2.2 Å resolution from a small (0.15 mm3) crystal of perdeuterated human aldose reductase (h‐AR; MW = 36 kDa) in…”
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Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex by Blakeley, M P, Mitschler, A, Hazemann, I, Meilleur, F, Myles, D A A, Podjarny, A

“…Protonation states determination by neutron (2.2 A at room temperature) and X-ray (0.66 A at 100 K) crystallographic studies were compared for a medium size…”
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Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase by Blakeley, Matthew P, Ruiz, Federico, Cachau, Raul, Hazemann, Isabelle, Meilleur, Flora, Mitschler, Andre, Ginell, Stephan, Afonine, Pavel, Ventura, Oscar N, Cousido-Siah, Alexandra, Haertlein, Michael, Joachimiak, Andrzej, Myles, Dean, Podjarny, Alberto

“…We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 Å, 100K; 0.80 Å, 15K; 1.75 Å,…”
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X-ray-induced deterioration of disulfide bridges at atomic resolution by Petrova, Tatiana, Ginell, Stephan, Mitschler, Andre, Kim, Youngchang, Lunin, Vladimir Y., Joachimiak, Grazyna, Cousido-Siah, Alexandra, Hazemann, Isabelle, Podjarny, Alberto, Lazarski, Krzysztof, Joachimiak, Andrzej

“…Overall and site‐specific X‐ray‐induced damage to porcine pancreatic elastase was studied at atomic resolution at temperatures of 100 and 15 K. The experiments…”
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The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop by Biadene, Marianna, Ginell, Steve, Cousido, Alexandra, Hazemann, Isabelle, Joachimiak, Andrzej, Sheldrick, George M., Podjarny, Alberto, Schneider, Thomas R.

“…The crystal structure of human aldose reductase in complex with citrate has been determined to a resolution of 0.82 Å. The difference electron density for H…”
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Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat by Petrova, Tatiana, Ginell, Stephan, Mitschler, Andre, Hazemann, Isabelle, Schneider, Thomas, Cousido, Alexandra, Lunin, Vladimir Y., Joachimiak, Andrzej, Podjarny, Alberto

“…Two X‐ray data sets for a complex of human aldose reductase (h‐AR) with the inhibitor IDD 594 and the cofactor NADP+ were collected from two different parts of…”
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Neutron data collection at room temperature with tiny crystals of perdeuterated proteins by Mitschler, A., Blakeley, M. P., Haertlein, M., Petit-Haertlein, I., Hazemann, I., Myles, D., Muller-Dieckmann, C., Popov, A., Podjarny, A.

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X-ray-induced overall structural changes in a protein molecule at cryogenic temperatures by Petrova, T., Lunin, V., Ginell, S., Mitschler, A., Kim, Y., Joachimiak, G., Cousido-Siah, A., Hazemann, I., Podjarny, A., Lazarski, K., Joachimiak, A.

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X-ray-induced cooperative atomic movements in protein crystals by Petrova, T., Ginell, S., Mitschler, A., Kim, Y., Lunin, V. Y., Joachimiak, G., Cousido-Siah, A., Hazemann, I., Podjarny, A., Lazarski, K., Joachimiak, A.

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Opening of the safety-belt loop of human aldose reductase by Biadene, M., Hazemann, I., Schneider, T. R.

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Protein neutron crystallography with 'tiny' crystals of fully deuterated proteins by Podjarny, A., Blakeley, M. P., Haertlein, M., Petit-Haertlein, I., Hazemann, I., Mitschler, A., Cousido-Siah, A., Fisher, S. J., Salvay, A. G., Muller-Dieckmann, C., Popov, A., Afonine, P., Ventura, O., Cachau, R., Ginell, S., Joachimiak, A., Meilleur, F., Petrova, T., Myles, D., Howard, E. I.

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Neutron diffraction structure of antifreeze protein leads to ice-binding model by Podjarny, A., Blakeley, M., Haertlein, M., Petit-Haertlein, I., Hazemann, I., Cousido, A., Mueller-Dieckmann, C., Popov, A., Mitschler, A., Howard, E.

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Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases : stuctural and thermodynamic properties of the aldose reductase mutant leu300pro-fidarestat complex by Petrova, T., Steuber, H., Hazemann, I., Cousido-Siah, A., Mitschler, A., Chung, R., Oka, M., Klebe, G., El-Kabbani, O., Joachimiak, A., Podjarny, A., Biosciences Division, Lab. de Genomique et de Biologie Structurales, Univ. of Marburg, Monash Univ, Sanwa Kagaku Kenkyusyo Co., Ltd

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Ultra high resolution X-ray and neutron diffraction studies of fully deuterated aldose reductase show a catalytic proton pathway by Ruiz, F., Mitschler, A., Hazemann, I., Blakely, M., Dauvergne, M.-T., Meilleur, F., Van Zandt, M., Ginell, S., Joachimiak, A., Myles, D., Podjarny, A.

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X-ray structures of aldose reductase-inhibitor complexes at 0.9 Å resolution from LN2-cryocooled crystals measured at 10 K by Mitschler, A., Ginell, S., Petrova, T., Hazemann, I., Cousido, A., Ruiza, F., Van Zandt, M., Joachimiak, A., Podjarny, A.

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Neutron diffraction structure of fully deuterated aldose reductase: a necessary complement to X-ray ultra-high-resolution structures by Podjarny, A., Mitschler, A., Hazemann, I., Petrova, T., Ruiz, F., Blakeley, M., Dauvergne, M. T., Meilleur, F., Van Zandt, M., Ginell, S., Joachimiak, A., Myles, D.

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Inhibitor binding to aldose reductase studied at subatomic resolution by Podjarny, A. D., Mitschler, A., Hazemann, I., Petrova, T., Ruiz, F., Howard, E., Darmanin, C., Chung, R., Schneider, T. R., Sanishvili, R., Schulze-Briesse, C., Tomizaki, T., Van Zandt, M., Oka, M., Joachimiak, A., El-Kabbani, O.

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The structure of an aldose-reductase inhibitor complex shows flexibility of the inhibitor's carboxylate as a function of pH by Mitschler, A., Cousido, A., Zink, F., Van Zandt, M., Cachau, R., Hazemann, I., Sanishvili, R., Joachimiak, A., Podjarny, A.

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