Search Results - "Hazeki, Osamu"

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  1. 1

    Role of Phosphoinositide 3-Kinase in Innate Immunity by Hazeki, Kaoru, Nigorikawa, Kiyomi, Hazeki, Osamu

    Published in Biological & Pharmaceutical Bulletin (01-09-2007)
    “…Recent advances in our understanding of the molecular basis of mammalian host immune responses to microbial invasion suggest that the first line of defense…”
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  2. 2

    Involvement of class II phosphoinositide 3-kinase α-isoform in antigen-induced degranulation in RBL-2H3 cells by Nigorikawa, Kiyomi, Hazeki, Kaoru, Guo, Ying, Hazeki, Osamu

    Published in PloS one (30-10-2014)
    “…In this study, we present findings that suggest that PI3K-C2α, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process of…”
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  3. 3

    Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice by Akao, Yuusuke, Ebihara, Takashi, Masuda, Hisayo, Saeki, Yoshiko, Akazawa, Takashi, Hazeki, Kaoru, Hazeki, Osamu, Matsumoto, Misako, Seya, Tsukasa

    Published in Cancer science (01-08-2009)
    “…Oral administration of hot‐water extract of Spirulina, cyanobacterium Spirulina platensis, leads to augmentation of NK cytotoxicity in humans. Here, we applied…”
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  4. 4

    PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses by Hazeki, Kaoru, Uehara, Masami, Nigorikawa, Kiyomi, Hazeki, Osamu

    Published in PloS one (09-09-2013)
    “…TLR9 is a receptor for oligodeoxynucleotides that contain unmethylated CpG motifs (CpG). Because TLR9 resides in the endoplasmic reticulum during the…”
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    Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2 by Nigorikawa, Kiyomi, Hazeki, Kaoru, Sasaki, Junko, Omori, Yumio, Miyake, Mikiko, Morioka, Shin, Guo, Ying, Sasaki, Takehiko, Hazeki, Osamu

    Published in PloS one (04-11-2015)
    “…Phagocytosis is a highly conserved process whereby phagocytic cells engulf pathogens and apoptotic bodies. The present study focused on the role of inositol…”
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  7. 7

    Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages by Morioka, Shin, Nigorikawa, Kiyomi, Hazeki, Kaoru, Ohmura, Michiko, Sakamoto, Hiromi, Matsumura, Takuma, Takasuga, Shunsuke, Hazeki, Osamu

    Published in Experimental cell research (15-08-2017)
    “…The findings of this study suggest that the phosphoinositide phosphatase Sac3 maintains the protein level of scavenger receptor A (SR-A) and regulates foam…”
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  8. 8

    Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics by Hazeki, Kaoru, Nigorikawa, Kiyomi, Takaba, Yuki, Segawa, Tomohiro, Nukuda, Akiko, Masuda, Ayaka, Ishikawa, Yuki, Kubota, Koji, Takasuga, Shunsuke, Hazeki, Osamu

    Published in FEBS letters (16-11-2012)
    “…► In macrophages lacking PIKfyve, PtdIns(3)P elimination from phagosome was delayed. ► In macrophages lacking PTEN, PtdIns(3)P elimination from phagosome was…”
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  9. 9

    Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model by Morioka, Shin, Nigorikawa, Kiyomi, Sasaki, Junko, Hazeki, Kaoru, Kasuu, Yoshihiro, Sasaki, Takehiko, Hazeki, Osamu

    Published in Innate immunity (London, England) (01-08-2016)
    “…Phosphatidylinositol 3-kinase (PI3K)/Akt signaling has been implicated in the anti-inflammatory response in a mouse model of endotoxemia and sepsis. The…”
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  10. 10

    Acute effects of melatonin and its time of administration on core body temperature and heart rate in cynomolgus monkeys by Inui, Yoshitaka, Hazeki, Osamu

    Published in Journal of toxicological sciences (01-06-2010)
    “…We examined the effects of exogenous melatonin and the time of its administration on core body temperature (CBT) and heart rate (HR) in cynomolgus monkeys…”
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  11. 11

    Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a by Segawa, Tomohiro, Hazeki, Kaoru, Nigorikawa, Kiyomi, Nukuda, Atsuko, Tanizawa, Tomoki, Miyamoto, Kenshiro, Morioka, Shin, Hazeki, Osamu

    Published in Innate immunity (London, England) (01-05-2017)
    “…The relative abundance of phosphoinositide (PI) species on the phagosome membrane fluctuates over the course of phagocytosis. PtdIns(3,4,5)P and PtdIns(3,4)P…”
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  12. 12

    Class-IA Phosphoinositide 3-Kinase p110β Triggers GPCR-Induced Superoxide Production in p110γ-Deficient Murine Neutrophils by Nigorikawa, Kiyomi, Hazeki, Kaoru, Kumazawa, Takashi, Itoh, Yuhta, Hoshi, Megumi, Hazeki, Osamu

    “…Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in…”
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  13. 13

    C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase by Okazaki, Natsumi, Hazeki, Kaoru, Izumi, Tatsuhiro, Nigorikawa, Kiyomi, Hazeki, Osamu

    Published in Journal of biochemistry (Tokyo) (01-03-2011)
    “…The complement system is a classic central player in innate immunity. Most pathogens activate both complement and the toll-like receptor (TLR) pathway…”
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  14. 14

    Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase Cδ Limits Fcγ Receptor-Mediated Phagocytosis in Macrophages by Hazeki, Kaoru, Inoue, Kazumi, Nigorikawa, Kiyomi, Hazeki, Osamu

    Published in Journal of biochemistry (Tokyo) (2009)
    “…Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC). Here, we showed…”
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  15. 15

    Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages by Hazeki, Kaoru, Kametani, Yukiko, Murakami, Hiroki, Uehara, Masami, Ishikawa, Yuki, Nigorikawa, Kiyomi, Takasuga, Shunsuke, Sasaki, Takehiko, Seya, Tsukasa, Matsumoto, Misako, Hazeki, Osamu

    Published in PloS one (2011)
    “…Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been…”
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  16. 16

    IRAK-4-dependent Degradation of IRAK-1 is a Negative Feedback Signal for TLR-mediated NF-κB Activation by Kubo-Murai, Miho, Hazeki, Kaoru, Nigorikawa, Kiyomi, Omoto, Takatoshi, Inoue, Norimitsu, Hazeki, Osamu

    Published in Journal of biochemistry (Tokyo) (01-03-2008)
    “…The activation of interleukin 1 receptor-associated kinase (IRAK)-1 is a key event in the transmission of signals from Toll-like receptors (TLRs). The…”
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    Inhibition of PTEN and activation of Akt by menadione by Yoshikawa, Kyoko, Nigorikawa, Kiyomi, Tsukamoto, Mariko, Tamura, Namiko, Hazeki, Kaoru, Hazeki, Osamu

    Published in Biochimica et biophysica acta (01-04-2007)
    “…Menadione (vitamin K 3) has been shown to activate Erk in several cell lines. This effect has been shown to be due to the activation of EGF receptors (EGFR) as…”
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  19. 19

    Activation of Insulin Receptors by Lagerstroemin by Hattori, Katsuji, Sukenobu, Naoe, Sasaki, Tomo, Takasuga, Shunsuke, Hayashi, Takeo, Kasai, Ryoji, Yamasaki, Kazuo, Hazeki, Osamu

    Published in Journal of Pharmacological Sciences (01-09-2003)
    “…Lagerstroemin, an ellagitannin isolated from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), was examined for its biological activities. In rat…”
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  20. 20

    Toll‐like receptor‐mediated tyrosine phosphorylation of paxillin via MyD88‐dependent and ‐independent pathways by Hazeki, Kaoru, Masuda, Naoyo, Funami, Kenji, Sukenobu, Naoe, Matsumoto, Misako, Akira, Shizuo, Takeda, Kiyoshi, Seya, Tsukasa, Hazeki, Osamu

    Published in European journal of immunology (01-03-2003)
    “…Toll‐like receptor (TLR)‐mediated recognition of pathogens represents one of the most important mechanisms of innate immunity. A proximal signaling event of…”
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