Search Results - "Hazeki, Osamu"
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Role of Phosphoinositide 3-Kinase in Innate Immunity
Published in Biological & Pharmaceutical Bulletin (01-09-2007)“…Recent advances in our understanding of the molecular basis of mammalian host immune responses to microbial invasion suggest that the first line of defense…”
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2
Involvement of class II phosphoinositide 3-kinase α-isoform in antigen-induced degranulation in RBL-2H3 cells
Published in PloS one (30-10-2014)“…In this study, we present findings that suggest that PI3K-C2α, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process of…”
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3
Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice
Published in Cancer science (01-08-2009)“…Oral administration of hot‐water extract of Spirulina, cyanobacterium Spirulina platensis, leads to augmentation of NK cytotoxicity in humans. Here, we applied…”
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4
PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses
Published in PloS one (09-09-2013)“…TLR9 is a receptor for oligodeoxynucleotides that contain unmethylated CpG motifs (CpG). Because TLR9 resides in the endoplasmic reticulum during the…”
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A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
Published in Molecular pharmacology (01-04-2006)“…Proinflammatory mediators such as cytokines and NO play pivotal roles in various inflammatory diseases. To combat inflammatory diseases successfully,…”
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Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2
Published in PloS one (04-11-2015)“…Phagocytosis is a highly conserved process whereby phagocytic cells engulf pathogens and apoptotic bodies. The present study focused on the role of inositol…”
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Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages
Published in Experimental cell research (15-08-2017)“…The findings of this study suggest that the phosphoinositide phosphatase Sac3 maintains the protein level of scavenger receptor A (SR-A) and regulates foam…”
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8
Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics
Published in FEBS letters (16-11-2012)“…► In macrophages lacking PIKfyve, PtdIns(3)P elimination from phagosome was delayed. ► In macrophages lacking PTEN, PtdIns(3)P elimination from phagosome was…”
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Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model
Published in Innate immunity (London, England) (01-08-2016)“…Phosphatidylinositol 3-kinase (PI3K)/Akt signaling has been implicated in the anti-inflammatory response in a mouse model of endotoxemia and sepsis. The…”
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10
Acute effects of melatonin and its time of administration on core body temperature and heart rate in cynomolgus monkeys
Published in Journal of toxicological sciences (01-06-2010)“…We examined the effects of exogenous melatonin and the time of its administration on core body temperature (CBT) and heart rate (HR) in cynomolgus monkeys…”
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11
Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a
Published in Innate immunity (London, England) (01-05-2017)“…The relative abundance of phosphoinositide (PI) species on the phagosome membrane fluctuates over the course of phagocytosis. PtdIns(3,4,5)P and PtdIns(3,4)P…”
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12
Class-IA Phosphoinositide 3-Kinase p110β Triggers GPCR-Induced Superoxide Production in p110γ-Deficient Murine Neutrophils
Published in Journal of Pharmacological Sciences (2012)“…Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in…”
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13
C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase
Published in Journal of biochemistry (Tokyo) (01-03-2011)“…The complement system is a classic central player in innate immunity. Most pathogens activate both complement and the toll-like receptor (TLR) pathway…”
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14
Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase Cδ Limits Fcγ Receptor-Mediated Phagocytosis in Macrophages
Published in Journal of biochemistry (Tokyo) (2009)“…Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC). Here, we showed…”
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15
Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages
Published in PloS one (2011)“…Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been…”
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IRAK-4-dependent Degradation of IRAK-1 is a Negative Feedback Signal for TLR-mediated NF-κB Activation
Published in Journal of biochemistry (Tokyo) (01-03-2008)“…The activation of interleukin 1 receptor-associated kinase (IRAK)-1 is a key event in the transmission of signals from Toll-like receptors (TLRs). The…”
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17
A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases
Published in Molecular pharmacology (01-09-2006)“…The 1,4-naphthoquinone derivative, shikonin, has been shown to increase glucose uptake by adipocytes and myocytes with minor effects on protein tyrosine…”
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18
Inhibition of PTEN and activation of Akt by menadione
Published in Biochimica et biophysica acta (01-04-2007)“…Menadione (vitamin K 3) has been shown to activate Erk in several cell lines. This effect has been shown to be due to the activation of EGF receptors (EGFR) as…”
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19
Activation of Insulin Receptors by Lagerstroemin
Published in Journal of Pharmacological Sciences (01-09-2003)“…Lagerstroemin, an ellagitannin isolated from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), was examined for its biological activities. In rat…”
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20
Toll‐like receptor‐mediated tyrosine phosphorylation of paxillin via MyD88‐dependent and ‐independent pathways
Published in European journal of immunology (01-03-2003)“…Toll‐like receptor (TLR)‐mediated recognition of pathogens represents one of the most important mechanisms of innate immunity. A proximal signaling event of…”
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