Search Results - "Hazawa, Masaharu"

Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex by Kato, Koki, Ikliptikawati, Dini Kurnia, Kobayashi, Akiko, Kondo, Hiroya, Lim, Keesiang, Hazawa, Masaharu, Wong, Richard W.

“…The novel human betacoronavirus SARS-CoV-2 has caused an unprecedented pandemic in the 21st century. Several studies have revealed interactions between…”
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Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer by Li, Li-Yan, Yang, Qian, Jiang, Yan-Yi, Yang, Wei, Jiang, Yuan, Li, Xiang, Hazawa, Masaharu, Zhou, Bo, Huang, Guo-Wei, Xu, Xiu-E, Gery, Sigal, Zhang, Ying, Ding, Ling-Wen, Ho, Allen S., Zumsteg, Zachary S., Wang, Ming-Rong, Fullwood, Melissa J., Freedland, Stephen J., Meltzer, Stephen J., Xu, Li-Yan, Li, En-Min, Koeffler, H. Phillip, Lin, De-Chen

“…Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of human cancer. Transcriptional dysregulation of SCC cells is orchestrated by…”
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The genomic landscape of nasopharyngeal carcinoma by Lin, De-Chen, Meng, Xuan, Hazawa, Masaharu, Nagata, Yasunobu, Varela, Ana Maria, Xu, Liang, Sato, Yusuke, Liu, Li-Zhen, Ding, Ling-Wen, Sharma, Arjun, Goh, Boon Cher, Lee, Soo Chin, Petersson, Bengt Fredrik, Yu, Feng Gang, Macary, Paul, Oo, Min Zin, Ha, Chan Soh, Yang, Henry, Ogawa, Seishi, Loh, Kwok Seng, Koeffler, H Phillip

“…De-Chen Lin and colleagues report whole-exome sequencing, targeted sequencing and SNP array analysis of 128 cases of nasopharyngeal carcinoma (NPC), a tumor…”
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Unlocking the Gateway: The Spatio-Temporal Dynamics of the p53 Family Driven by the Nuclear Pores and Its Implication for the Therapeutic Approach in Cancer by Ikliptikawati, Dini Kurnia, Makiyama, Kei, Hazawa, Masaharu, Wong, Richard W

“…The p53 family remains a captivating focus of an extensive number of current studies. Accumulating evidence indicates that p53 abnormalities rank among the…”
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Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression by Jiang, Yuan, Jiang, Yan-Yi, Xie, Jian-Jun, Mayakonda, Anand, Hazawa, Masaharu, Chen, Li, Xiao, Jin-Fen, Li, Chun-Quan, Huang, Mo-Li, Ding, Ling-Wen, Sun, Qiao-Yang, Xu, Liang, Kanojia, Deepika, Jeitany, Maya, Deng, Jian-Wen, Liao, Lian-Di, Soukiasian, Harmik J., Berman, Benjamin P., Hao, Jia-Jie, Xu, Li-Yan, Li, En-Min, Wang, Ming-Rong, Bi, Xin-Gang, Lin, De-Chen, Koeffler, H. Phillip

“…Squamous cell carcinomas (SCCs) are aggressive malignancies. Previous report demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited…”
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NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells by Makiyama, Kei, Hazawa, Masaharu, Kobayashi, Akiko, Lim, Keesiang, Voon, Dominic C., Wong, Richard W.

“…Nuclear pore complexes (NPC) regulate molecular traffics on nuclear envelope, which plays crucial roles during cell fate specification and diseases. The viral…”
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Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core by Mohamed, Mahmoud Shaaban, Hazawa, Masaharu, Kobayashi, Akiko, Guillaud, Laurent, Watanabe-Nakayama, Takahiro, Nakayama, Mizuho, Wang, Hanbo, Kodera, Noriyuki, Oshima, Masanobu, Ando, Toshio, Wong, Richard W.

“…Nuclear pore complex (NPC) is a gating nanomachine with a central selective barrier composed mainly of Nups, which contain intrinsically disordered…”
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Inhibition of Canonical Wnt Signaling Promotes Ex Vivo Maintenance and Proliferation of Hematopoietic Stem Cells in Zebrafish by Kimura, Koki, Yamamori, Shiori, Hazawa, Masaharu, Kobayashi-Sun, Jingjing, Kondo, Mao, Wong, Richard W, Kobayashi, Isao

“…Abstract The maintenance and proliferation of hematopoietic stem cells (HSCs) are tightly regulated by their niches in the bone marrow. The analysis of niche…”
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Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma by Dewi, Firli Rahmah Primula, Jiapaer, Shabierjiang, Kobayashi, Akiko, Hazawa, Masaharu, Ikliptikawati, Dini Kurnia, Hartono, Sabit, Hemragul, Nakada, Mitsutoshi, Wong, Richard W

“…Children with ependymoma have high mortality rates because ependymoma is resistant to conventional therapy. Genomic and transcriptomic studies have identified…”
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Nanoscopic Assessment of Anti-SARS-CoV‑2 Spike Neutralizing Antibody Using High-Speed AFM by Lim, Keesiang, Nishide, Goro, Sajidah, Elma Sakinatus, Yamano, Tomoyoshi, Qiu, Yujia, Yoshida, Takeshi, Kobayashi, Akiko, Hazawa, Masaharu, Ando, Toshio, Hanayama, Rikinari, Wong, Richard W.

“…Anti-spike neutralizing antibodies (S NAbs) have been developed for prevention and treatment against COVID-19. The nanoscopic characterization of the dynamic…”
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Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma by Hazawa, Masaharu, Sakai, Kie, Kobayashi, Akiko, Yoshino, Hironori, Iga, Yoshihiro, Iwashima, Yuki, Lim, Kee Sing, Chih-Cheng Voon, Dominic, Jiang, Yan-Yi, Horike, Shin-ichi, Lin, De-Chen, Wong, Richard W.

“…Nuclear import, mediated in part by karyopherin-α (KPNA)/importin-α subtypes, regulates transcription factor access to the genome and determines cell fate…”
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High-Speed Atomic Force Microscopy Reveals Loss of Nuclear Pore Resilience as a Dying Code in Colorectal Cancer Cells by Mohamed, Mahmoud Shaaban, Kobayashi, Akiko, Taoka, Azuma, Watanabe-Nakayama, Takahiro, Kikuchi, Yosuke, Hazawa, Masaharu, Minamoto, Toshinari, Fukumori, Yoshihiro, Kodera, Noriyuki, Uchihashi, Takayuki, Ando, Toshio, Wong, Richard W

“…Nuclear pore complexes (NPCs) are the sole turnstile implanted in the nuclear envelope (NE), acting as a central nanoregulator of transport between the cytosol…”
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High-Speed Atomic Force Microscopy Reveals Spatiotemporal Dynamics of Histone Protein H2A Involution by DNA Inchworming by Nishide, Goro, Lim, Keesiang, Mohamed, Mahmoud Shaaban, Kobayashi, Akiko, Hazawa, Masaharu, Watanabe-Nakayama, Takahiro, Kodera, Noriyuki, Ando, Toshio, Wong, Richard W

“…DNA–histone interaction is always perturbed by epigenetic regulators to regulate gene expression. Direct visualization of this interaction is yet to be…”
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Direct visualization of avian influenza H5N1 hemagglutinin precursor and its conformational change by high-speed atomic force microscopy by Lim, Kee Siang, Mohamed, Mahmoud Shaaban, Wang, Hanbo, Hartono, Hazawa, Masaharu, Kobayashi, Akiko, Voon, Dominic Chih-Cheng, Kodera, Noriyuki, Ando, Toshio, Wong, Richard W.

“…Hemagglutinin (HA) of influenza A is one of the key virulence factors that mediates the release of viral components in host cells. HA is initially synthesized…”
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Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells by Lim, Kee Siang, Yong, Zachary Wei Ern, Wang, Huajing, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Yamamoto, Daisuke, Inaki, Noriyuki, Hazawa, Masaharu, Wong, Richard W., Oshima, Hiroko, Oshima, Masanobu, Ito, Yoshiaki, Voon, Dominic Chih-Cheng

“…The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and…”
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Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer by Jiang, Yuan, Zheng, Yueyuan, Zhang, Yuan-Wei, Kong, Shuai, Dong, Jinxiu, Wang, Fei, Ziman, Benjamin, Gery, Sigal, Hao, Jia-Jie, Zhou, Dan, Zhou, Jianian, Ho, Allen S., Sinha, Uttam K., Chen, Jian, Zhang, Shuo, Yin, Chuntong, Wei, Dan-Dan, Hazawa, Masaharu, Pan, Huaguang, Lu, Zhihao, Wei, Wen-Qiang, Wang, Ming-Rong, Koeffler, H. Phillip, Lin, De-Chen, Jiang, Yan-Yi

“…Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved…”
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Label-free tomographic imaging of nanodiamonds in living cells by Ikliptikawati, Dini Kurnia, Hazawa, Masaharu, So, Frederick T.-K., Terada, Daiki, Kobayashi, Akiko, Segawa, Takuya F., Shirakawa, Masahiro, Wong, Richard W.

“…Nanodiamonds have acknowledged growing attention due to their facile functionalization, stable fluorescence, low toxicity, and decent biocompatibility…”
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Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation by Hazawa, Masaharu, Tomiyama, Kenichi, Saotome-Nakamura, Ai, Obara, Chizuka, Yasuda, Takeshi, Gotoh, Takaya, Tanaka, Izumi, Yakumaru, Haruko, Ishihara, Hiroshi, Tajima, Katsushi

“…•Radiation increases cellular uptake of exosomes.•Radiation induces colocalization of CD29 and CD81.•Exosomes selectively bind the CD29/CD81 complex.•Radiation…”
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Nuclear transport surveillance of p53 by nuclear pores in glioblastoma by Ikliptikawati, Dini Kurnia, Hirai, Nozomi, Makiyama, Kei, Sabit, Hemragul, Kinoshita, Masashi, Matsumoto, Koki, Lim, Keesiang, Meguro-Horike, Makiko, Horike, Shin-ichi, Hazawa, Masaharu, Nakada, Mitsutoshi, Wong, Richard W.

“…Nuclear pore complexes (NPCs) are the central apparatus of nucleocytoplasmic transport. Disease-specific alterations of NPCs contribute to the pathogenesis of…”
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Synthetic zwitterions as efficient non-permeable cryoprotectants by Kato, Yui, Uto, Takuya, Tanaka, Daisuke, Ishibashi, Kojiro, Kobayashi, Akiko, Hazawa, Masaharu, Wong, Richard W., Ninomiya, Kazuaki, Takahashi, Kenji, Hirata, Eishu, Kuroda, Kosuke

“…Cryopreservation of cells is necessary for long periods of storage. However, some cell lines cannot be efficiently cryopreserved, even when optimized…”
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