Search Results - "Hazari, Younis"

A chosen STING with a PERKy trail by Hazari, Younis, Hetz, Claudio

“…Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway…”
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Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response by Dufey, Estefanie, Bravo-San Pedro, José Manuel, Eggers, Cristian, González-Quiroz, Matías, Urra, Hery, Sagredo, Alfredo I., Sepulveda, Denisse, Pihán, Philippe, Carreras-Sureda, Amado, Hazari, Younis, Sagredo, Eduardo A., Gutierrez, Daniela, Valls, Cristian, Papaioannou, Alexandra, Acosta-Alvear, Diego, Campos, Gisela, Domingos, Pedro M., Pedeux, Rémy, Chevet, Eric, Alvarez, Alejandra, Godoy, Patricio, Walter, Peter, Glavic, Alvaro, Kroemer, Guido, Hetz, Claudio

“…The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the…”
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Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics by Carreras-Sureda, Amado, Jaña, Fabián, Urra, Hery, Durand, Sylvere, Mortenson, David E., Sagredo, Alfredo, Bustos, Galdo, Hazari, Younis, Ramos-Fernández, Eva, Sassano, Maria L., Pihán, Philippe, van Vliet, Alexander R., González-Quiroz, Matías, Torres, Angie K., Tapia-Rojas, Cheril, Kerkhofs, Martijn, Vicente, Rubén, Kaufman, Randal J., Inestrosa, Nibaldo C., Gonzalez-Billault, Christian, Wiseman, R. Luke, Agostinis, Patrizia, Bultynck, Geert, Court, Felipe A., Kroemer, Guido, Cárdenas, J. César, Hetz, Claudio

“…Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum…”
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IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A by Urra, Hery, Henriquez, Daniel R., Cánovas, José, Villarroel-Campos, David, Carreras-Sureda, Amado, Pulgar, Eduardo, Molina, Emiliano, Hazari, Younis M., Limia, Celia M., Alvarez-Rojas, Sebastián, Figueroa, Ricardo, Vidal, Rene L., Rodriguez, Diego A., Rivera, Claudia A., Court, Felipe A., Couve, Andrés, Qi, Ling, Chevet, Eric, Akai, Ryoko, Iwawaki, Takao, Concha, Miguel L., Glavic, Álvaro, Gonzalez-Billault, Christian, Hetz, Claudio

“…Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified…”
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Aggregation of M3 (E376D) variant of alpha1- antitrypsin by Bashir, Arif, Hazari, Younis, Pal, Debnath, Maity, Dibyajyoti, Bashir, Samirul, Singh, Laishram Rajendrakumar, Shah, Naveed Nazir, Fazili, Khalid Majid

“…Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has an important role in neutralizing the neutrophil elastase activity…”
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Author Correction: IRE1α governs cytoskeleton remodeling and cell migration through a direct interaction with filamin A by Urra, Hery, Henriquez, Daniel R., Cánovas, José, Villarroel-Campos, David, Carreras-Sureda, Amado, Pulgar, Eduardo, Molina, Emiliano, Hazari, Younis M., Limia, Celia M., Alvarez-Rojas, Sebastián, Figueroa, Ricardo, Vidal, Rene L., Rodriguez, Diego A., Rivera, Claudia A., Court, Felipe A., Couve, Andrés, Qi, Ling, Chevet, Eric, Akai, Ryoko, Iwawaki, Takao, Concha, Miguel L., Glavic, Álvaro, Gonzalez-Billault, Christian, Hetz, Claudio

“…A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00673-2…”
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Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics by Carreras-Sureda, Amado, Jaña, Fabián, Urra, Hery, Durand, Sylvere, Mortenson, David E., Sagredo, Alfredo, Bustos, Galdo, Hazari, Younis, Ramos-Fernández, Eva, Sassano, Maria L., Pihán, Philippe, van Vliet, Alexander R., González-Quiroz, Matías, Torres, Angie K., Tapia-Rojas, Cheril, Kerkhofs, Martijn, Vicente, Rubén, Kaufman, Randal J., Inestrosa, Nibaldo C., Gonzalez-Billault, Christian, Wiseman, R. Luke, Agostinis, Patrizia, Bultynck, Geert, Court, Felipe A., Kroemer, Guido, Cárdenas, J. César, Hetz, Claudio

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A by Urra, Hery, Henriquez, Daniel R., Cánovas, José, Villarroel-Campos, David, Carreras-Sureda, Amado, Pulgar, Eduardo, Molina, Emiliano, Hazari, Younis M., Limia, Celia M., Alvarez-Rojas, Sebastián, Figueroa, Ricardo, Vidal, Rene L., Rodriguez, Diego A., Rivera, Claudia A., Court, Felipe A., Couve, Andrés, Qi, Ling, Chevet, Eric, Akai, Ryoko, Iwawaki, Takao, Concha, Miguel L., Glavic, Álvaro, Gonzalez-Billault, Christian, Hetz, Claudio

“…In the version of this Article originally published, the competing interests statement was missing. The authors declare no competing interests; this statement…”
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SERPINA1 Hepatocyte-Specific Promoter Polymorphism Associate with Chronic Obstructive Pulmonary Disease in a Study of Kashmiri Ancestry Individuals by Bashir, Arif, Hazari, Younis M., Bashir, Samirul, Hilal, Nazia, Banday, Mariam, Iqbal, Mir Khurshid, Jan, Tariq Rashid, Farooq, Syed Suraiya, Shah, Naveed Nazir, Fazili, Khalid Majid

“…Purpose Different mutations in coding and non-coding sequences of the SERPINA1 gene have been implicated in the pathogenesis of COPD. However, − 10T/C mutation…”
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Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease by Lebeaupin, Cynthia, Vallée, Deborah, Hazari, Younis, Hetz, Claudio, Chevet, Eric, Bailly-Maitre, Béatrice

“…The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease (NAFLD), with manifestations ranging from simple…”
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Autophagy in hepatic adaptation to stress by Hazari, Younis, Bravo-San Pedro, José Manuel, Hetz, Claudio, Galluzzi, Lorenzo, Kroemer, Guido

“…Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support…”
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ER stress signaling at the interphase between MASH and hepatocellular carcinoma by Hazari, Younis, Chevet, Eric, Bailly-Maitre, Béatrice, Hetz, Claudio

“…Hepato-cellular carcinoma (HCC) is the most frequent primary liver cancer with an extremely poor prognosis and often develops on preset of chronic liver…”
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ER stress signaling at the interphase between MASH and HCC by Hazari, Younis, Chevet, Eric, Bailly-Maitre, Béatrice, Hetz, Claudio

“…HCC is the most frequent primary liver cancer with an extremely poor prognosis and often develops on preset of chronic liver diseases. Major risk factors for…”
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Fusobacterium nucleatum, inflammation, and immunity: the fire within human gut by Bashir, Arif, Miskeen, Abid Yousuf, Hazari, Younis Mohammad, Asrafuzzaman, Syed, Fazili, Khalid Majid

“…Fusobacterium nucleatum is an identified proinflammatory autochthonous bacterium implicated in human colorectal cancer. It is also abundantly found in patients…”
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Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α by Sepulveda, Denisse, Rojas-Rivera, Diego, Rodríguez, Diego A., Groenendyk, Jody, Köhler, Andres, Lebeaupin, Cynthia, Ito, Shinya, Urra, Hery, Carreras-Sureda, Amado, Hazari, Younis, Vasseur-Cognet, Mireille, Ali, Maruf M.U., Chevet, Eric, Campos, Gisela, Godoy, Patricio, Vaisar, Tomas, Bailly-Maitre, Béatrice, Nagata, Kazuhiro, Michalak, Marek, Sierralta, Jimena, Hetz, Claudio

“…Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1α is a…”
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Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions by Hazari, Younis Mohammad, Bashir, Arif, Habib, Mudasir, Bashir, Samirul, Habib, Huma, Qasim, M. Abul, Shah, Naveed Nazir, Haq, Ehtishamul, Teckman, Jeffrey, Fazili, Khalid Majid

“…Alpha-1-antitrypsin (AAT) is an acute phase secretory glycoprotein that inhibits neutrophil proteases like elastase and is considered as the archetype of a…”
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Emerging tale of UPR and cancer: an essentiality for malignancy by Hazari, Younis Mohammad, Bashir, Arif, Haq, Ehtisham ul, Fazili, Khalid Majid

“…A set of cellular response to counter any alteration in homeostasis of a cell originating at endoplasmic reticulum is collectively termed as unfolded protein…”
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Expression and purification of p70ΔCT 104 S6 K, a 72 kDa c-terminal truncated p70S6 kinase-GST fusion protein in bacterial expression system by Hazari, Younis Mohammad, Reshi, Irfana, Habib, Mudasir, Fazili, Khalid Majid

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Expression and purification of p70ΔCT104 S6 K, a 72kDa c-terminal truncated p70S6 kinase-GST fusion protein in bacterial expression system by Hazari, Younis Mohammad, Reshi, Irfana, Habib, Mudasir, Fazili, Khalid Majid

“…The p70ΔCT104 S6K is a 421 amino acid residue long truncated form of p70S6 kinase, with 104 amino acids residues cleaved from the carboxyl terminal end of the…”
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Novel variants of SERPIN1A gene: Interplay between alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease by Bashir, Arif, Shah, Naveed Nazir, Hazari, Younis Mohammad, Habib, Mudasir, Bashir, Samirul, Hilal, Nazia, Banday, Mariam, Asrafuzzaman, Syed, Fazili, Khalid Majid

“…Abstract Alpha1-antitrypsin (AAT) is one of the major circulating anti-protease whose levels in circulation are raised during excessive amount of proteases,…”
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