Search Results - "Hazan, Rachel B."

Cadherin Switch in Tumor Progression by HAZAN, RACHEL B., QIAO, RUI, KEREN, RINAT, BADANO, INES, SUYAMA, KIMITA

“…: The loss of E‐cadherin expression or function in epithelial carcinomas has long been thought as a primary reason for disruption of tight epithelial cell‐cell…”
Get full text

Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis by SEAHO KIM, JIAHONG YAO, MACIAN, Fernando, NORTON, Larry, HAZAN, Rachel B, SUYAMA, Kimita, XIA QIAN, QIAN, Bin-Zhi, BANDYOPADHYAY, Sanmay, LOUDIG, Olivier, DE LEON-RODRIGUEZ, Carlos, ZHEN NI ZHOU, SEGALL, Jeffrey

“…Tumor cells must overcome apoptosis to survive throughout metastatic dissemination and distal organ colonization. Here, we show in the Polyoma Middle T mammary…”
Get full text

N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation by HULIT, James, SUYAMA, Kimita, HAZAN, Rachel B, CHUNG, Su, KEREN, Rinat, AGIOSTRATIDOU, Georgia, WEISONG SHAN, XINYUAN DONG, WILLIAMS, Terence M, LISANTI, Michael P, KNUDSEN, Karen

“…N-cadherin is up-regulated in aggressive breast carcinomas, but its mechanism of action in vivo remains unknown. Transgenic mice coexpressing N-cadherin and…”
Get full text

Exogenous Expression of N-Cadherin in Breast Cancer Cells Induces Cell Migration, Invasion, and Metastasis by Hazan, Rachel B., Phillips, Greg R., Qiao, Rui Fang, Norton, Larry, Aaronson, Stuart A.

“…E- and N-cadherin are calcium-dependent cell adhesion molecules that mediate cell-cell adhesion and also modulate cell migration and tumor invasiveness. The…”
Get full text

Differential Cadherin Expression: Potential Markers for Epithelial to Mesenchymal Transformation During Tumor Progression by Agiostratidou, Georgia, Hulit, James, Phillips, Greg R, Hazan, Rachel B

“…The cadherin family of adhesion molecules regulates cell-cell interactions during development and in tissues. The prototypical cadherin, E-cadherin, is…”
Get full text

Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis by AGIOSTRATIDOU, Georgia, MAOMI LI, EUGENIN, Eliseo, LOUDIG, Olivier, PHILLIPS, Greg R, LOCKER, Joseph, HAZAN, Rachel B, SUYAMA, Kimita, BADANO, Ines, KEREN, Rinat, CHUNG, Su, ANZOVINO, Amy, HULIT, James, BINZHI QIAN, BOUZAHZAH, Boumediene

“…The mammary epithelium is thought to be stabilized by cell-cell adhesion mediated mainly by E-cadherin (E-cad). Here, we show that another cadherin, retinal…”
Get full text

Tracking Surface Glycans on Live Cancer Cells with Single-Molecule Sensitivity by Jiang, Hao, English, Brian P., Hazan, Rachel B., Wu, Peng, Ovryn, Ben

“…Using a combination of metabolically labeled glycans, a bioorthogonal copper(I)‐catalyzed azide–alkyne cycloaddition, and the controlled bleaching of…”
Get full text

Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer by Ren, Zuen, Liang, Huizhi, Galbo, Jr, Phillip M, Dharmaratne, Malindrie, Kulkarni, Ameya S, Fard, Atefeh Taherian, Aoun, Marie Louise, Martinez-Lopez, Nuria, Suyama, Kimita, Benard, Outhiriaradjou, Zheng, Wei, Liu, Yang, Albanese, Joseph, Zheng, Deyou, Mar, Jessica C, Singh, Rajat, Prystowsky, Michael B, Norton, Larry, Hazan, Rachel B

“…In search of redox mechanisms in breast cancer, we uncovered a striking role for glutathione peroxidase 2 (GPx2) in oncogenic signaling and patient survival…”
Get full text

Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α by Ren, Zuen, Dharmaratne, Malindrie, Liang, Huizhi, Benard, Outhiriaradjou, Morales-Gallego, Miriam, Suyama, Kimita, Kumar, Viney, Fard, Atefeh Taherian, Kulkarni, Ameya S., Prystowsky, Michael, Mar, Jessica C., Norton, Larry, Hazan, Rachel B.

“…Background Redox signaling caused by knockdown (KD) of Glutathione Peroxidase 2 (GPx2) in the PyMT mammary tumour model promotes metastasis via phenotypic and…”
Get full text

p21CIP1 Promotes Mammary Cancer-Initiating Cells via Activation of Wnt/TCF1/CyclinD1 Signaling by Benard, Outhiriaradjou, Qian, Xia, Liang, Huizhi, Ren, Zuen, Suyama, Kimita, Norton, Larry, Hazan, Rachel B

“…Cancer stem cells (CSC) generate and sustain tumors due to tumor-initiating potential, resulting in recurrence or metastasis. We showed that knockout of the…”
Get full text

A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor by Suyama, Kimita, Shapiro, Irina, Guttman, Mitchell, Hazan, Rachel B.

“…The intracellular signaling events causing tumor cells to become metastatic are not well understood. N-cadherin and FGF-2 synergistically increase migration,…”
Get full text

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy by Amgalan, Dulguun, Garner, Thomas P, Pekson, Ryan, Jia, Xiaotong F, Yanamandala, Mounica, Paulino, Victor, Liang, Felix G, Corbalan, J Jose, Lee, Jaehoon, Chen, Yun, Karagiannis, George S, Sanchez, Luis Rivera, Liang, Huizhi, Narayanagari, Swathi-Rao, Mitchell, Kelly, Lopez, Andrea, Margulets, Victoria, Scarlata, Marco, Santulli, Gaetano, Asnani, Aarti, Peterson, Randall T, Hazan, Rachel B, Condeelis, John S, Oktay, Maja H, Steidl, Ulrich, Kirshenbaum, Lorrie A, Gavathiotis, Evripidis, Kitsis, Richard N

“…Doxorubicin remains an essential component of many cancer regimens, but its use is limited by lethal cardiomyopathy, which has been difficult to target, owing…”
Get full text

An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis by Suyama, Kimita, Yao, Jiahong, Liang, Huizhi, Benard, Outhiriaradjou, Loudig, Olivier D, Amgalan, Dulguun, McKimpson, Wendy M, Phillips, Greg R, Segall, Jeffrey, Wang, Yihong, Fineberg, Susan, Norton, Larry, Kitsis, Richard N, Hazan, Rachel B

“…The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory…”
Get full text

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion by Williams, Terence M, Medina, Freddy, Badano, Ines, Hazan, Rachel B, Hutchinson, John, Muller, William J, Chopra, Neeru G, Scherer, Philipp E, Pestell, Richard G, Lisanti, Michael P

“…Caveolin-1 (Cav-1) is the principal structural component of caveolae membrane domains in non-muscle cells, including mammary epithelia. There is now clear…”
Get full text

LC3-dependent Intracellular Membrane Tubules Induced by γ-Protocadherins A3 and B2: A ROLE FOR INTRALUMINAL INTERACTIONS by Hanson, Hugo H, Kang, Semie, Fernández-Monreal, Mónica, Oung, Twethida, Yildirim, Murat, Lee, Rebecca, Suyama, Kimita, Hazan, Rachel B, Phillips, Greg R

“…Clustered protocadherins (Pcdhs) are a family of cadherin-like molecules arranged in gene clusters (α, β, and γ). γ-Protocadherins (Pcdh-γs) are involved in…”
Get full text

The Epidermal Growth Factor Receptor Modulates the Interaction of E-cadherin with the Actin Cytoskeleton by Hazan, Rachel B., Norton, Larry

“…Alterations in the expression or function of molecules that affect cellular adhesion and proliferation are thought to be critical events for tumor progression…”
Get full text

N-cadherin expression in breast cancer : correlation with an aggressive histologic variant - invasive micropapillary carcinoma by NAGI, Chandandeep, GUTTMAN, Mitchell, JAFFER, Shabnam, RUI QIAO, KEREN, Rinat, TRIANA, Aymara, MAOMI LI, GODBOLD, James, BLEIWEISS, Ira J, HAZAN, Rachel B

“…Upregulation of N-cadherin in epithelial tumor cells has been shown to contribute to the invasive/metastatic phenotype. It remains however to be determined…”
Get full text

Tracking Surface Glycans on Live Cancer Cells with Single-Molecule Sensitivity by Jiang, Hao, English, Brian P., Hazan, Rachel B., Wu, Peng, Ovryn, Ben

“…Using a combination of metabolically labeled glycans, a bioorthogonal copper(I)‐catalyzed azide–alkyne cycloaddition, and the controlled bleaching of…”
Get full text

Abstract 4666: p21CIP1 promotes mammary cancer initiating cells via activation of Wnt/TCF1/CyclinD1 signaling by Hazan, Rachel B.

“…Abstract Cancer stem cells (CSCs) generate and sustain tumors due to tumor initiating potential, resulting in recurrence or metastasis. We showed previously…”
Get full text

Abstract 313: An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis by Hazan, Rachel B.

“…Abstract The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key…”
Get full text