Search Results - "Hayward, Neil J"

TRPA1 mediates formalin-induced pain by McNamara, Colleen R, Mandel-Brehm, Josh, Bautista, Diana M, Siemens, Jan, Deranian, Kari L, Zhao, Michael, Hayward, Neil J, Chong, Jayhong A, Julius, David, Moran, Magdalene M, Fanger, Christopher M

“…The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a…”
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Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis by Everaerts, Wouter, Zhen, Xiaoguang, Ghosh, Debapriya, Vriens, Joris, Gevaert, Thomas, Gilbert, James P., Hayward, Neil J., McNamara, Colleen R., Xue, Fenqin, Moran, Magdalene M., Strassmaier, Timothy, Uykal, Eda, Owsianik, Grzegorz, Vennekens, Rudi, De Ridder, Dirk, Nilius, Bernd, Fanger, Christopher M., Voets, Thomas, Aldrich, Richard W.

“…Reduced functional bladder capacity and concomitant increased micturition frequency (pollakisuria) are common lower urinary tract symptoms associated with…”
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sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma by Caceres, Ana I, Brackmann, Marian, Elia, Maxwell D, Bessac, Bret F, del Camino, Donato, D'Amours, Marc, Witek, JoAnn S, Fanger, Chistopher M, Chong, Jayhong A, Hayward, Neil J, Homer, Robert J, Cohn, Lauren, Huang, Xiaozhu, Moran, Magdalene M, Jordt, Sven-Eric

“…Asthma is an inflammatory disorder caused by airway exposures to allergens and chemical irritants. Studies focusing on immune, smooth muscle, and airway…”
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TRPA1 contributes to cold hypersensitivity by del Camino, Donato, Murphy, Sarah, Heiry, Melissa, Barrett, Lee B, Earley, Taryn J, Cook, Colby A, Petrus, Matt J, Zhao, Michael, D'Amours, Marc, Deering, Nate, Brenner, Gary J, Costigan, Michael, Hayward, Neil J, Chong, Jayhong A, Fanger, Christopher M, Woolf, Clifford J, Patapoutian, Ardem, Moran, Magdalene M

“…TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety…”
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Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis by Ji, Niannian, Somanaboeina, Animesh, Dixit, Aakanksha, Kawamura, Kazuyuki, Hayward, Neil J, Self, Christopher, Olson, Gary L, Forsthuber, Thomas G

“…The strong association of HLA-DR2b (DRB1*1501) with multiple sclerosis (MS) suggests this molecule as prime target for specific immunotherapy. Inhibition of…”
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EP-7041, a Factor XIa Inhibitor as a Potential Antithrombotic Strategy in Extracorporeal Membrane Oxygenation: A Brief Report by Pollack, Jr, Charles V, Kurz, Michael A, Hayward, Neil J

“…Current approaches to systemic antithrombotic therapy in support of extracorporeal membrane oxygenation are limited and are hampered by both thrombotic and…”
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Design, Synthesis, and Biological Evaluation of Peptidomimetic Inhibitors of Factor XIa as Novel Anticoagulants by Lin, Jian, Deng, Hongfeng, Jin, Lei, Pandey, Pramod, Quinn, Jesse, Cantin, Susan, Rynkiewicz, Michael J, Gorga, Joan C, Bibbins, Frank, Celatka, Cassandra A, Nagafuji, Pamela, Bannister, Thomas D, Meyers, Harold V, Babine, Robert E, Hayward, Neil J, Weaver, David, Benjamin, Howard, Stassen, Frans, Abdel-Meguid, Sherin S, Strickler, James E

“…Human coagulation factor XIa (FXIa), a serine protease activated by site-specific cleavage of factor XI by thrombin, FXIIa, or autoactivation, is a critical…”
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Modified-Peptide Inhibitors of Amyloid β-Peptide Polymerization by Findeis, Mark A, Musso, Gary M, Arico-Muendel, Christopher C, Benjamin, Howard W, Hundal, Arvind M, Lee, Jung-Ja, Chin, Joseph, Kelley, Michael, Wakefield, James, Hayward, Neil J, Molineaux, Susan M

“…Cellular toxicity resulting from nucleation-dependent polymerization of amyloid β-peptide (Aβ) is considered to be a major and possibly the primary component…”
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Brain temperature and the neuroprotective action of enadoline and dizocilpine in the gerbil model of global ischaemia by Hayward, N J, McKnight, A T, Woodruff, G N

“…Mongolian gerbils were subjected to transient forebrain ischaemia by occluding both common carotid arteries for 7 min. Subcutaneous administration of either…”
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Calpain Inhibitor AK295 Attenuates Motor and Cognitive Deficits Following Experimental Brain Injury in the Rat by Saatman, Kathryn E., Murai, Hisayuki, Bartus, Raymond T., Smith, Douglas H., Hayward, Neil J., Perri, Brian R., McIntosh, Tracy K.

“…Marked increases in intracellular calcium may play a role in mediating cellular dysfunction and death following central nervous system trauma, in part through…”
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Unlocking the Blood–Brain Barrier: A Role for RMP-7 in Brain Tumor Therapy by Elliott, Peter J., Hayward, Neil J., Huff, Michael R., Nagle, Tricia L., Black, Keith L., Bartus, Raymond T.

“…The effect and mechanism of the blood–brain barrier-permeabilizing agent, RMP-7, was investigated in a series of studies employing a rat RG2 glioma model…”
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Lack of Evidence for Neutrophil Participation during Infarct Formation Following Focal Cerebral Ischemia in the Rat by Hayward, Neil J., Elliott, Peter J., Sawyer, Sean D., Bronson, Roderick T., Bartus, Raymond T.

“…The involvement of neutrophils in the pathogenesis of cerebral ischemic injury in two rat models of focal ischemia was investigated. In Experiment I, a model…”
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Calpain as a novel target for treating acute neurodegenerative disorders by Bartus, R T, Elliott, P J, Hayward, N J, Dean, R L, Harbeson, S, Straub, J A, Li, Z, Powers, J C

“…Calpains are cytosolic, neutral proteases that normally exist in an inactive or quiescent state. They require higher than normal levels of calcium for…”
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Calpain inhibitor AK295 protects neurons from focal brain ischemia: Effects of postocclusion intra-arterial administration / Editorial comment by Bartus, Raymond T, Hayward, Neil J, Elliott, Peter J, Sawyer, Sean D

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The effect of dizocilpine and enadoline on immediate early gene expression in the gerbil global ischaemia model by Woodburn, V L, Hayward, N J, Poat, J A, Woodruff, G N, Hughes, J

“…Increases in mRNA levels for c-fos, c-jun, junB, hsp70 and NGFI-A were observed in the dentate gyrus of the hippocampus following 7 min ischaemia in the…”
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