Search Results - "Hayward, Daniel"

Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1 by Hayward, Daniel, Alfonso‐Pérez, Tatiana, Gruneberg, Ulrike

“…In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore attachments during capture of chromosomes by the mitotic…”
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Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint by Zhang, Gang, Lischetti, Tiziana, Hayward, Daniel G., Nilsson, Jakob

“…The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Checkpoint…”
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MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling by Alfonso-Pérez, Tatiana, Hayward, Daniel, Holder, James, Gruneberg, Ulrike, Barr, Francis A

“…Cyclin B-dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter…”
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Synergy between Multiple Microtubule-Generating Pathways Confers Robustness to Centrosome-Driven Mitotic Spindle Formation by Hayward, Daniel, Metz, Jeremy, Pellacani, Claudia, Wakefield, James G.

“…The mitotic spindle is defined by its organized, bipolar mass of microtubules, which drive chromosome alignment and segregation. Although different cells have…”
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Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex by Sedgwick, Garry G, Hayward, Daniel G, Di Fiore, Barbara, Pardo, Mercedes, Yu, Lu, Pines, Jonathon, Nilsson, Jakob

“…The Anaphase Promoting Complex/Cyclosome (APC/C) in complex with its co‐activator Cdc20 is responsible for targeting proteins for ubiquitin‐mediated…”
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CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization by Hayward, Daniel, Alfonso-Pérez, Tatiana, Cundell, Michael J, Hopkins, Michael, Holder, James, Bancroft, James, Hutter, Lukas H, Novak, Bela, Barr, Francis A, Gruneberg, Ulrike

“…Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a…”
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Comprehensive identification of SUMO2/3 targets and their dynamics during mitosis by Schou, Julie, Kelstrup, Christian D, Hayward, Daniel G, Olsen, Jesper V, Nilsson, Jakob

“…During mitosis large alterations in cellular structures occur rapidly, which to a large extent is regulated by post-translational modification of proteins…”
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Nek2 kinase in chromosome instability and cancer by Hayward, Daniel G., Fry, Andrew M.

“…Aneuploidy and chromosome instability are two of the most common abnormalities in cancer cells. They arise through defects in cell division and, specifically,…”
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Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function by Krshnan, Logesvaran, Siu, Wingyan Skyla, Van de Weijer, Michael, Hayward, Daniel, Guerrero, Elena Navarro, Gruneberg, Ulrike, Carvalho, Pedro

“…Nuclear architecture and functions depend on dynamic interactions between nuclear components (such as chromatin) and inner nuclear membrane (INM) proteins…”
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Widespread non‐coding polymorphism in HLA class II genes of International HLA and Immunogenetics Workshop cell lines by Turner, Thomas R., Hayward, Daniel R., Gymer, Arthur W., Barker, Dominic J., Leen, Gayle, Cambridge, Charlotte A., Macpherson, Hannah L., Georgiou, Xenia, Cooper, Michael A., Lucas, Jonathan A. M., Nadeem, Daud, Robinson, James, Mayor, Neema P., Marsh, Steven G. E.

“…As the primary genetic determinant of immune recognition of self and non‐self, the hyperpolymorphic HLA genes play key roles in disease association and…”
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Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation by Pellacani, Claudia, Bucciarelli, Elisabetta, Renda, Fioranna, Hayward, Daniel, Palena, Antonella, Chen, Jack, Bonaccorsi, Silvia, Wakefield, James G, Gatti, Maurizio, Somma, Maria Patrizia

“…Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether…”
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The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer by HAYWARD, Daniel G, CLARKE, Robert B, FARAGHER, Alison J, PILLAI, Meenu R, HAGAN, Iain M, FRY, Andrew M

“…Aneuploidy and chromosome instability are common abnormalities in human cancer. Loss of control over mitotic progression, multipolar spindle formation, and…”
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Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase by Wu, Wenjuan, Baxter, Joanne E., Wattam, Samantha L., Hayward, Daniel G., Fardilha, Margarida, Knebel, Axel, Ford, Eleanor M., da Cruz e Silva, Edgar F., Fry, Andrew M.

“…Nek2 is a cell cycle-regulated serine/threonine protein kinase that is up-regulated in human cancers. Functionally, it is implicated in control of centrosome…”
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Use of a non-endoscopic immunocytological device (Cytosponge™) for post chemoradiotherapy surveillance in patients with oesophageal cancer in the UK (CYTOFLOC): A multicentre feasibility study by Jones, Christopher M, O'Connor, Heather, O'Donovan, Maria, Hayward, Daniel, Blasko, Adrienn, Harman, Ruth, Malhotra, Shalini, Debiram-Beecham, Irene, Alias, Bincy, Bailey, Adam, Bateman, Andrew, Crosby, Tom D L, Falk, Stephen, Gollins, Simon, Hawkins, Maria A, Kadri, Sudarshan, Levy, Stephanie, Radhakrishna, Ganesh, Roy, Rajarshi, Sripadam, Raj, Fitzgerald, Rebecca C, Mukherjee, Somnath

“…Effective surveillance strategies are required for patients diagnosed with oesophageal squamous cell carcinoma (OSCC) or adenocarcinoma (OAC) for whom…”
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Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated nek2 kinase by Hayward, Daniel G, Newbatt, Yvette, Pickard, Lisa, Byrne, Eilis, Mao, Guojie, Burns, Samantha, Sahota, Navdeep K, Workman, Paul, Collins, Ian, Aherne, Wynne, Fry, Andrew M

“…Nek2 is a serine/threonine protein kinase that localizes to the centrosome and is implicated in mitotic regulation. Overexpression of Nek2 induces premature…”
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MPS1 localizes to end-on microtubule-attached kinetochores to promote microtubule release by Hayward, Daniel, Roberts, Emile, Gruneberg, Ulrike

“…In eukaryotes, the spindle assembly checkpoint protects genome stability in mitosis by preventing chromosome segregation until incorrect…”
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Selection of Alternative 5′ Splice Sites: Role of U1 snRNP and Models for the Antagonistic Effects of SF2/ASF and hnRNP A1 by Eperon, Ian C., Makarova, Olga V., Mayeda, Akila, Munroe, Stephen H., Cáceres, Javier F., Hayward, Daniel G., Krainer, Adrian R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development by Pedersen, Marianne Terndrup, Kooistra, Susanne Marije, Radzisheuskaya, Aliaksandra, Laugesen, Anne, Johansen, Jens Vilstrup, Hayward, Daniel Geoffrey, Nilsson, Jakob, Agger, Karl, Helin, Kristian

“…Chromatin‐associated proteins are essential for the specification and maintenance of cell identity. They exert these functions through modulating and…”
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Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56 by Hayward, Daniel, Bancroft, James, Mangat, Davinderpreet, Alfonso-Pérez, Tatiana, Dugdale, Sholto, McCarthy, Julia, Barr, Francis A, Gruneberg, Ulrike

“…During mitosis, the formation of microtubule-kinetochore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1). MPS1 is recruited…”
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The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment by Legal, Thibault, Hayward, Daniel, Gluszek-Kustusz, Agata, Blackburn, Elizabeth A, Spanos, Christos, Rappsilber, Juri, Gruneberg, Ulrike, Welburn, Julie P I

“…During cell division, misaligned chromosomes are captured and aligned by motors before their segregation. The CENP-E motor is recruited to polar unattached…”
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