Search Results - "Hayward, Cheryl"

Synthesis of Quinazolin-4(3H)‑ones via Amidine N‑Arylation by Li, Bryan, Samp, Lacey, Sagal, John, Hayward, Cheryl M, Yang, Christine, Zhang, Zhijun

“…Pyrido[4,3-d]pyrimidin-4(3H)-one (1) was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd2(dba)3 and Xantphos,…”
Get full text

Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor by Duan, Shengquan, Widlicka, Daniel W, Burns, Michael P, Kumar, Rajesh, Hotham, Ian, Desrosiers, Jean-Nicolas, Bowles, Paul, Jones, Kris N, Nicholson, Lindsay D, Buetti-Weekly, Michele T, Han, Lu, Steflik, Jeremy, Hansen, Eric, Hayward, Cheryl M, Strohmeyer, Holly, Monfette, Sébastien, Sutton, Scott C, Morris, Christopher

“…Biocatalytic reductive amination catalyzed by engineered imine reductase (RedAms) is a new and powerful tool for the synthesis of substituted chiral amines…”
Get full text

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors by Li, Bryan, Barnhart, Richard W, Dion, Amelie, Guinness, Steven, Happe, Alan, Hayward, Cheryl M, Kohrt, Jeffrey, Makowski, Teresa, Maloney, Mark, Nelson, Jade D, Nematalla, Asaad, McWilliams, J. Christopher, Peng, Zhihui, Raggon, Jeffrey, Sagal, John, Weisenburger, Gerald A, Bao, Denghui, Gonzalez, Miguel, Lu, Jiangping, McLaws, Mark D, Tao, Jian, Wu, Baolin

“…Process development for the synthesis of a second generation β-amyloid-cleaving enzyme (BACE1) inhibitor (1) is described. The lithiothiazole addition to the…”
Get full text

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules by Thompson, John F, Wang, Ing-Kae, Stutzman-Engwall, Kim J, Freeman, Thomas B, Chrunyk, Boris A, Hayward, Cheryl M, Ammirati, Mark J, Cong, Yang, Lloyd, David B, Subashi, Timothy A, Karam, George A, Hoth, Lise R, McGrath, Katherine M, Seddon, Andrew P, Lira, Maruja E, Mistry, Anil, Hawrylik, Steven J, Qiu, Xiayang, Geoghegan, Kieran F, Griffor, Matthew C, Hensley, Preston, Clark, Ronald W, Danley, Dennis E, Subashi, Ann K, Zhao, Honglei, Culp, Jeffrey S

“…Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from…”
Get full text

Student Aboriginal health worker smoking: findings from a training college in Western Australia by Hoad, Veronica, Hayward, Cheryl

Get full text

Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo by Kane, Christopher D, Stevens, Kimberly A, Fischer, James E, Haghpassand, Mehrdad, Royer, Lori J, Aldinger, Charles, Landschulz, Katherine T, Zagouras, Panayiotis, Bagley, Scott W, Hada, William, Dullea, Robert, Hayward, Cheryl M, Francone, Omar L

“…The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is recognized as the primary target of the fibrate class of hypolipidemic…”
Get more information

Process Development of a Novel Azetidinyl Ketolide Antibiotic by Li, Bryan, Magee, Thomas V, Buzon, Richard A, Widlicka, Daniel W, Bill, Dave R, Brandt, Thomas, Cao, Xiaoping, Coutant, Michael, Dou, Haijian, Granskog, Karl, Flanagan, Mark E, Hayward, Cheryl M, Li, Bin, Liu, Fengwei, Liu, Wei, Nguyen, Thuy-Trinh, Raggon, Jeffrey W, Rose, Peter, Rainville, Joseph, Reilly, Usa Datta, Shen, Yue, Sun, Jianmin, Wilcox, Glenn E

“…Process development and the multikilogram synthesis of a novel azetidinyl ketolide antibiotic is described. Starting with clarithromycin, the eight-step…”
Get full text

Total synthesis of rapamycin via a novel titanium-mediated aldol macrocyclization reaction by Hayward, Cheryl M, Yohannes, Daniel, Danishefsky, Samuel J

Get full text

Process Development of a Triphasic Continuous Flow Suzuki–Miyaura Coupling Reaction in a Plug Flow Reactor by Li, Bryan, Barnhart, Richard W., Fung, Peter, Hayward, Cheryl, Heid, Richard, Houck, Timothy, Liu, Weiguo, Samp, Lacey, Sutherland, Karen, Van Alsten, John, Varsolona, Richard, Zeldis, Joseph

“…We have successfully adapted a Suzuki–Miyaura coupling reaction to a continuous flow process. The reaction was a triphasic mixture involved with two liquid…”
Get full text

Developing a Multistep Continuous Manufacturing Process for (1R,2R)‑2-Amino-1-methylcyclopentan-1-ol by Duan, Shengquan, Feng, Xichun, Gonzalez, Miguel, Bader, Scott, Hayward, Cheryl, Ljubicic, Tomislav, Lu, Jiangping, Mustakis, Jason, Maloney, Mark, Rainville, Joseph, Zhang, Xin

“…A multistep continuous manufacturing process to synthesize (1R,2R)-2-amino-1-methylcyclopentan-1-ol (2) was developed. The step 1/2 flow process mitigated the…”
Get full text

Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497 by Ashcroft, Christopher P., Berne, Alexander M., Blasberg, Florian, Catlin, Kelly, Collins, Michael R., Critcher, Doug J., Desrosiers, Jean-Nicolas, Goetz, Adam, Hayward, Cheryl, Jones, Ricky A., Karmilowicz, Michael J., Keene, Nandell, Martinez, Carlos A., Monfette, Sebastien, Pattavina, Sebastian David, Perfect, Hahdi H., Ragan, John A., Rauschenberger, Blake, Sach, Neal W., Scotney, Gemma, Sutton, Scott C., Talicska, Courtney, Twiddle, Steven J.R., Haitsma, Jared Van, Wisdom, Richard

“…A cost-efficient approach for the synthesis of a key intermediate of the EZH2 inhibitor PF-06821497 was identified after performing process chemistry…”
Get full text

Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU) 2 Zn(CF 2 H) 2 ] and Improved Synthesis of the ICHF 2 Precursor by Monfette, Sebastien, Fang, Yuan-Qing, Bio, Matthew M., Brown, Adam R., Crouch, Ian T., Desrosiers, Jean-Nicolas, Duan, Shengquan, Hawkins, Joel M., Hayward, Cheryl M., Peperni, Nikita, Rainville, Joseph P.

Get full text

Telescoped Flow Process for the Syntheses of N‑Aryl Pyrazoles by Li, Bryan, Widlicka, Daniel, Boucher, Steven, Hayward, Cheryl, Lucas, John, Murray, John C, O’Neil, Brian T, Pfisterer, David, Samp, Lacey, VanAlsten, John, Xiang, Yanqiao, Young, Joseph

“…N-Aryl pyrazoles were prepared from anilines in a three step telescoped approach. An aniline was diazotized to give the diazonium fluoroborate, followed by…”
Get full text

A radical chlorodifluoromethylation protocol for late-stage difluoromethylation and its application to an oncology candidate by Meng, Depei, Li, Lingchun, Brown, Adam, Desrosiers, Jean-Nicolas, Duan, Shengquan, Hayward, Cheryl M., He, Zhengbiao, Hu, Jinbo, Makowski, Teresa, Maloney, Mark, Monfette, Sébastien, Perfect, Hahdi, Piper, Jared L., Zhou, Min, Widlicka, Daniel W.

“…Radical fluoroalkylation is a powerful synthetic tool for the late-stage incorporation of fluorinated moieties into organic molecules, which is widely used in…”
Get full text

Continuous flow aminolysis under high temperature and pressure by Li, Bryan, Bader, Scott, Guinness, Steve M., Ruggeri, Sally Gut, Hayward, Cheryl M., Hoagland, Steve, Lucas, John, Li, Ruizhi, Limburg, David, McWilliams, J. Christopher, Raggon, Jeffrey, Van Alsten, John

“…Under continuous processing conditions, C-N bond formation via SN 2 and SNAr substitutions by amines can be an effective preparative method, especially when…”
Get full text

Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis by Pandit, J, Danley, D E, Schulte, G K, Mazzalupo, S, Pauly, T A, Hayward, C M, Hamanaka, E S, Thompson, J F, Harwood, Jr, H J

“…Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP)…”
Get full text

Crystal Structure of Human Squalene Synthase by Pandit, Jayvardhan, Danley, Dennis E., Schulte, Gayle K., Mazzalupo, Stacy, Pauly, Thomas A., Hayward, Cheryl M., Hamanaka, Ernest S., Thompson, John F., Harwood, H. James

“…Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP)…”
Get full text

A Critical Role for Peroxisomal Proliferator-Activated Receptor-α Nuclear Receptors in the Development of Cardiomyocyte Degeneration and Necrosis by Pruimboom-Brees, Ingrid, Haghpassand, Mehrdad, Royer, Lori, Brees, Dominique, Aldinger, Charles, Reagan, William, Singh, Jatinder, Kerlin, Roy, Kane, Christopher, Bagley, Scott, Hayward, Cheryl, Loy, James, O'Brien, Peter, Francone, Omar L.

“…Peroxisomal proliferator-activated receptor (PPAR)-α is a ligand-activated transcriptional factor that regulates genes involved in lipid metabolism and energy…”
Get full text

A Critical Role for Peroxisomal Proliferator-Activated Receptor-{alpha} Nuclear Receptors in the Development of Cardiomyocyte Degeneration and Necrosis by Pruimboom-Brees, Ingrid, Haghpassand, Mehrdad, Royer, Lori, Brees, Dominique, Aldinger, Charles, Reagan, William, Singh, Jatinder, Kerlin, Roy, Kane, Christopher, Bagley, Scott, Hayward, Cheryl, Loy, James, O'Brien, Peter, Francone, Omar L

“…Peroxisomal proliferator-activated receptor (PPAR)-g is a ligand-activated transcriptional factor that regulates genes involved in lipid metabolism and energy…”
Get full text

Total synthesis of rapamycin by Hayward, Cheryl Myers

“…A total synthesis of the immunosuppressant rapamycin is described. This unique macrolide contains an $\alpha,\beta$-diketoamide moiety, a triene and a vast…”
Get full text