Search Results - "Hayward, Catherine P. M."

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  1. 1

    The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes by Hayward, Catherine P M, Liang, Minggao, Tasneem, Subia, Soomro, Asim, Waye, John S, Paterson, Andrew D, Rivard, Georges E, Wilson, Michael D

    Published in PloS one (16-03-2017)
    “…Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but…”
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    Journal Article
  2. 2

    An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts by Hayward, Catherine P M, Moffat, Karen A, Pai, Menaka, Liu, Yang, Seecharan, Jodi, McKay, Heather, Webert, Kathryn E, Cook, Richard J, Heddle, Nancy M

    Published in Thrombosis and haemostasis (01-07-2008)
    “…Light transmission platelet aggregation tests are important for diagnosing platelet function defects. However, uncertainties exist about the best procedures to…”
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    Journal Article
  3. 3

    Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes by Diamandis, Maria, Paterson, Andrew D., Rommens, Johanna M., Veljkovic, D. Kika, Blavignac, Jessica, Bulman, Dennis E., Waye, John S., Derome, Francine, Rivard, Georges E., Hayward, Catherine P.M.

    Published in Blood (12-02-2009)
    “…Quebec platelet disorder (QPD) is an autosomal dominant disorder with high penetrance that is associated with increased risks for bleeding. The hallmark of QPD…”
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    Journal Article
  4. 4

    Development of North American Consensus Guidelines for Medical Laboratories That Perform and Interpret Platelet Function Testing Using Light Transmission Aggregometry by HAYWARD, Catherine P. M, MOFFAT, Karen A, RABY, Anne, ISRAELS, Sara, PLUMHOFF, Elizabeth, FLYNN, Greg, ZEHNDER, James L

    Published in American journal of clinical pathology (01-12-2010)
    “…Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and…”
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    Journal Article Conference Proceeding
  5. 5

    Quebec platelet disorder: features, pathogenesis and treatment by Diamandis, Maria, Veljkovic, D Kika, Maurer-Spurej, Elisabeth, Rivard, Georges E, Hayward, Catherine PM

    Published in Blood coagulation & fibrinolysis (01-03-2008)
    “…Quebec platelet disorder (QPD) is a rare, autosomal-dominant, inherited bleeding disorder that is associated with unique abnormalities in fibrinolysis. Its…”
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    Journal Article
  6. 6

    Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene by Paterson, Andrew D., Rommens, Johanna M., Bharaj, Bhupinder, Blavignac, Jessica, Wong, Isidro, Diamandis, Maria, Waye, John S., Rivard, Georges E., Hayward, Catherine P.M.

    Published in Blood (11-02-2010)
    “…Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder linked to a region on chromosome 10 that includes PLAU, the urokinase plasminogen…”
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    Journal Article
  7. 7

    Diagnostic evaluation of platelet function disorders by Hayward, Catherine P.M

    Published in Blood reviews (01-07-2011)
    “…Abstract Platelet function disorders are inherited and acquired conditions that represent a common cause of bleeding. Their clinical findings are generally…”
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    Journal Article
  8. 8

    Thrombin generation abnormalities in commonly encountered platelet function disorders by Sharma, Tanmya, Brunet, Justin G., Tasneem, Subia, Smith, Stephanie A., Morrissey, James H., Hayward, Catherine P.M.

    “…Introduction Studies of thrombin generation (TG) with platelet‐rich plasma (PRP) and platelet‐poor plasma (PPP) have provided insights on bleeding disorders…”
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    Journal Article
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    Laboratory investigations for bleeding disorders by Hayward, Catherine P M, Moffat, Karen A, Liu, Yang

    Published in Seminars in thrombosis and hemostasis (01-10-2012)
    “…Bleeding disorder panels often include the prothrombin time (PT)/international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen…”
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    Journal Article
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    Endocytosis and storage of plasma factor V by human megakaryocytes by Suehiro, Youko, Veljkovic, Dragoslava Kika, Fuller, Nola, Motomura, Yasuaki, Massé, Jean Marc, Cramer, Elisabeth M, Hayward, Catherine P M

    Published in Thrombosis and haemostasis (01-09-2005)
    “…Factor V is an essential coagulation cofactor that circulates in plasma and platelet alpha-granules where it is stored complexed to multimerin I (MMRN1). To…”
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    Journal Article
  13. 13

    Critical Values in the Coagulation Laboratory: Results of a Survey of the North American Specialized Coagulation Laboratory Association by PAI, Menaka, MOFFAT, Karen A, PLUMHOFF, Elizabeth, HAYWARD, Catherine P. M

    Published in American journal of clinical pathology (01-12-2011)
    “…Critical values are vital to safe clinical and laboratory practice. To address the lack of information on critical values in coagulation, pattern-of-practice…”
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    Journal Article
  14. 14

    A prospective cohort study of light transmission platelet aggregometry for bleeding disorders: is testing native platelet-rich plasma non-inferior to testing platelet count adjusted samples? by Castilloux, Jean Francois, Moffat, Karen A, Liu, Yang, Seecharan, Jodi, Pai, Menaka, Hayward, Catherine P M

    Published in Thrombosis and haemostasis (01-10-2011)
    “…Light transmission platelet aggregometry (LTA) is important to diagnose bleeding disorders. Experts recommend testing LTA with native (N) rather than platelet…”
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    Journal Article
  15. 15

    Bleeding risks for uncharacterized platelet function disorders by Brunet, Justin, Badin, Matthew, Chong, Michael, Iyer, Janaki, Tasneem, Subia, Graf, Lucas, Rivard, Georges E., Paterson, Andrew D., Pare, Guillaume, Hayward, Catherine P.M.

    “…The bleeding risks for nonsyndromic platelet function disorders (PFDs) that impair aggregation responses and/or cause dense granule deficiency (DGD) are…”
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    Journal Article
  16. 16

    Results of an External Proficiency Testing Exercise on Platelet Dense-Granule Deficiency Testing by Whole Mount Electron Microscopy by HAYWARD, Catherine P. M, MOFFAT, Karen A, SPITZER, Ernie, TIMLECK, Marnie, PLUMHOFF, Elizabeth, ISRAELS, Sara J, WHITE, James

    Published in American journal of clinical pathology (01-05-2009)
    “…Performance on specialized diagnostic tests for platelet disorders, including dense-granule deficiency, is rarely evaluated by external quality assessment…”
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    Journal Article
  17. 17

    Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder by Sheth, Prameet M, Kahr, Walter H A, Haq, M Anwar, Veljkovic, Dragoslava Kika, Rivard, Georges E, Hayward, Catherine P M

    Published in Thrombosis and haemostasis (01-08-2003)
    “…The Quebec Platelet Disorder (QPD) is an unusual bleeding disorder associated with increased platelet stores of urokinase-type plasminogen activator (u-PA) and…”
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    Journal Article
  18. 18

    Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North American Specialized Coagulation Laboratory Association by Moffat, Karen A, Ledford-Kraemer, Marlies R, Nichols, William L, Hayward, Catherine P M

    Published in Thrombosis and haemostasis (01-03-2005)
    “…Disorders of platelet function are important causes of abnormal bleeding that require laboratory tests for diagnosis. Currently there are limited guidelines on…”
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    Journal Article
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    Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation by Veljkovic, D. Kika, Rivard, Georges E., Diamandis, Maria, Blavignac, Jessica, Cramer-Bordé, Elisabeth M., Hayward, Catherine P.M.

    Published in Blood (12-02-2009)
    “…Quebec platelet disorder (QPD) is an inherited bleeding disorder associated with increased urokinase plasminogen activator (uPA) in platelets but not in…”
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    Journal Article
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    Laboratory testing for fibrinogen abnormalities by Verhovsek, Madeleine, Moffat, Karen A., Hayward, Catherine P.M.

    Published in American journal of hematology (01-12-2008)
    “…Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered…”
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    Journal Article