Search Results - "Hayward, Catherine P. M."
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The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes
Published in PloS one (16-03-2017)“…Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but…”
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An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts
Published in Thrombosis and haemostasis (01-07-2008)“…Light transmission platelet aggregation tests are important for diagnosing platelet function defects. However, uncertainties exist about the best procedures to…”
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Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes
Published in Blood (12-02-2009)“…Quebec platelet disorder (QPD) is an autosomal dominant disorder with high penetrance that is associated with increased risks for bleeding. The hallmark of QPD…”
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Development of North American Consensus Guidelines for Medical Laboratories That Perform and Interpret Platelet Function Testing Using Light Transmission Aggregometry
Published in American journal of clinical pathology (01-12-2010)“…Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and…”
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Quebec platelet disorder: features, pathogenesis and treatment
Published in Blood coagulation & fibrinolysis (01-03-2008)“…Quebec platelet disorder (QPD) is a rare, autosomal-dominant, inherited bleeding disorder that is associated with unique abnormalities in fibrinolysis. Its…”
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Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene
Published in Blood (11-02-2010)“…Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder linked to a region on chromosome 10 that includes PLAU, the urokinase plasminogen…”
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Diagnostic evaluation of platelet function disorders
Published in Blood reviews (01-07-2011)“…Abstract Platelet function disorders are inherited and acquired conditions that represent a common cause of bleeding. Their clinical findings are generally…”
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Thrombin generation abnormalities in commonly encountered platelet function disorders
Published in International journal of laboratory hematology (01-12-2021)“…Introduction Studies of thrombin generation (TG) with platelet‐rich plasma (PRP) and platelet‐poor plasma (PPP) have provided insights on bleeding disorders…”
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Laboratory investigations for bleeding disorders
Published in Seminars in thrombosis and hemostasis (01-10-2012)“…Bleeding disorder panels often include the prothrombin time (PT)/international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen…”
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Analytical Performance of COVID-19 Detection Methods (RT-PCR): Scientific and Societal Concerns
Published in Life (Basel, Switzerland) (06-07-2021)“…Health and social management of the SARS-CoV-2 epidemic, responsible for the COVID-19 disease, requires both screening tools and diagnostic procedures…”
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Endocytosis and storage of plasma factor V by human megakaryocytes
Published in Thrombosis and haemostasis (01-09-2005)“…Factor V is an essential coagulation cofactor that circulates in plasma and platelet alpha-granules where it is stored complexed to multimerin I (MMRN1). To…”
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Critical Values in the Coagulation Laboratory: Results of a Survey of the North American Specialized Coagulation Laboratory Association
Published in American journal of clinical pathology (01-12-2011)“…Critical values are vital to safe clinical and laboratory practice. To address the lack of information on critical values in coagulation, pattern-of-practice…”
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A prospective cohort study of light transmission platelet aggregometry for bleeding disorders: is testing native platelet-rich plasma non-inferior to testing platelet count adjusted samples?
Published in Thrombosis and haemostasis (01-10-2011)“…Light transmission platelet aggregometry (LTA) is important to diagnose bleeding disorders. Experts recommend testing LTA with native (N) rather than platelet…”
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Bleeding risks for uncharacterized platelet function disorders
Published in Research and practice in thrombosis and haemostasis (01-07-2020)“…The bleeding risks for nonsyndromic platelet function disorders (PFDs) that impair aggregation responses and/or cause dense granule deficiency (DGD) are…”
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Results of an External Proficiency Testing Exercise on Platelet Dense-Granule Deficiency Testing by Whole Mount Electron Microscopy
Published in American journal of clinical pathology (01-05-2009)“…Performance on specialized diagnostic tests for platelet disorders, including dense-granule deficiency, is rarely evaluated by external quality assessment…”
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Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder
Published in Thrombosis and haemostasis (01-08-2003)“…The Quebec Platelet Disorder (QPD) is an unusual bleeding disorder associated with increased platelet stores of urokinase-type plasminogen activator (u-PA) and…”
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Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North American Specialized Coagulation Laboratory Association
Published in Thrombosis and haemostasis (01-03-2005)“…Disorders of platelet function are important causes of abnormal bleeding that require laboratory tests for diagnosis. Currently there are limited guidelines on…”
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Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation
Published in Blood (12-02-2009)“…Quebec platelet disorder (QPD) is an inherited bleeding disorder associated with increased urokinase plasminogen activator (uPA) in platelets but not in…”
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Laboratory testing for fibrinogen abnormalities
Published in American journal of hematology (01-12-2008)“…Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered…”
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