Search Results - "Hayward, Caroline"
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A general approach for haplotype phasing across the full spectrum of relatedness
Published in PLoS genetics (01-04-2014)“…Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or by chance. Haplotype estimation in such cohorts is a…”
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Genomic analysis of family data reveals additional genetic effects on intelligence and personality
Published in Molecular psychiatry (01-12-2018)“…Pedigree-based analyses of intelligence have reported that genetic differences account for 50–80% of the phenotypic variation. For personality traits these…”
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Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents
Published in The American journal of psychiatry (01-10-2020)“…Objective:Death by suicide is a highly preventable yet growing worldwide health crisis. To date, there has been a lack of adequately powered genomic studies of…”
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Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Published in Nature communications (16-12-2019)“…Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a…”
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5
Integrating omics datasets with the OmicsPLS package
Published in BMC bioinformatics (11-10-2018)“…With the exponential growth in available biomedical data, there is a need for data integration methods that can extract information about relationships between…”
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A meta-analysis of genome-wide association studies of epigenetic age acceleration
Published in PLoS genetics (18-11-2019)“…'Epigenetic age acceleration' is a valuable biomarker of ageing, predictive of morbidity and mortality, but for which the underlying biological mechanisms are…”
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7
Runs of Homozygosity in European Populations
Published in American journal of human genetics (01-09-2008)“…Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the…”
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The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution
Published in Journal of the American Society of Nephrology (01-10-2016)“…Common variants in the UMOD gene encoding uromodulin, associated with risk of hypertension and CKD in the general population, increase UMOD expression and…”
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Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course
Published in European journal of human genetics : EJHG (01-06-2016)“…The association between APOE genotype and cognitive function suggests a positive role for the e2 allele and a negative role for the e4 allele. Both alleles…”
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Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk
Published in International journal of molecular sciences (01-04-2023)“…Infectious diseases still threaten global human health, and host genetic factors have been indicated as determining risk factors for observed variations in…”
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Genetic regulation of post-translational modification of two distinct proteins
Published in Nature communications (24-03-2022)“…Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology…”
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Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
Published in Nature communications (06-09-2017)“…Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has…”
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13
Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research
Published in Molecular & cellular proteomics (01-06-2014)“…The biological and clinical relevance of glycosylation is becoming increasingly recognized, leading to a growing interest in large-scale clinical and…”
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Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
Published in PLoS medicine (06-07-2023)“…DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS)…”
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The Effect of Mediterranean Diet on Thyroid Gland Activity
Published in International journal of molecular sciences (01-06-2024)“…The main goal of this research was to determine whether there is a correlation between adherence to the Mediterranean diet (assessed by the Mediterranean Diet…”
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Refining epigenetic prediction of chronological and biological age
Published in Genome medicine (28-02-2023)“…Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of…”
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Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation
Published in PLoS genetics (02-02-2016)“…Genome-wide association studies have successfully identified thousands of loci for a range of human complex traits and diseases. The proportion of phenotypic…”
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18
Complement C3 Variant and the Risk of Age-Related Macular Degeneration
Published in The New England journal of medicine (09-08-2007)“…A variant on complement factor 3 is associated with age-related macular degeneration, with a population attributable risk of 22%. This finding underlines the…”
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An epigenome-wide association study of sex-specific chronological ageing
Published in Genome medicine (31-12-2019)“…Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy…”
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Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
Published in PLoS genetics (06-07-2020)“…To efficiently transform genetic associations into drug targets requires evidence that a particular gene, and its encoded protein, contribute causally to a…”
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