Search Results - "Hayward, B."

CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons by Billon, Pierre, Bryant, Eric E., Joseph, Sarah A., Nambiar, Tarun S., Hayward, Samuel B., Rothstein, Rodney, Ciccia, Alberto

“…Standard CRISPR-mediated gene disruption strategies rely on Cas9-induced DNA double-strand breaks (DSBs). Here, we show that CRISPR-dependent base editing…”
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Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant by Nambiar, Tarun S., Billon, Pierre, Diedenhofen, Giacomo, Hayward, Samuel B., Taglialatela, Angelo, Cai, Kunheng, Huang, Jen-Wei, Leuzzi, Giuseppe, Cuella-Martin, Raquel, Palacios, Andrew, Gupta, Anuj, Egli, Dieter, Ciccia, Alberto

“…Precise editing of genomic DNA can be achieved upon repair of CRISPR-induced DNA double-stranded breaks (DSBs) by homology-directed repair (HDR). However, the…”
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MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage by Huang, Jen-Wei, Acharya, Ananya, Taglialatela, Angelo, Nambiar, Tarun S., Cuella-Martin, Raquel, Leuzzi, Giuseppe, Hayward, Samuel B., Joseph, Sarah A., Brunette, Gregory J., Anand, Roopesh, Soni, Rajesh K., Clark, Nathan L., Bernstein, Kara A., Cejka, Petr, Ciccia, Alberto

“…Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP,…”
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A review of the Australian–New Zealand sector of the Southern Ocean over the last 30 ka (Aus-INTIMATE project) by Bostock, H.C., Barrows, T.T., Carter, L., Chase, Z., Cortese, G., Dunbar, G.B., Ellwood, M., Hayward, B., Howard, W., Neil, H.L., Noble, T.L., Mackintosh, A., Moss, P.T., Moy, A.D., White, D., Williams, M.J.M., Armand, L.K.

“…The Australia/New Zealand region of the Southern Ocean is influenced by several of the major global water masses of the oceans and is the prime entry point for…”
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Monte Carlo Tree Search in Hex by Arneson, B, Hayward, R B, Henderson, P

“…Hex, the classic board game invented by Piet Hein in 1942 and independently by John Nash in 1948, has been a domain of AI research since Claude Shannon's…”
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Effectiveness of recombinant human follicle-stimulating hormone (r-hFSH): recombinant human luteinizing hormone versus r-hFSH alone in assisted reproductive technology treatment cycles among women aged 35-40 years: A German database study by Bielfeld, A P, Schwarze, J E, Verpillat, P, Lispi, M, Fischer, R, Hayward, B, Chuderland, D, D'Hooghe, T, Krussel, J S

“…This non-interventional study compared the effectiveness of recombinant human follicle-stimulating hormone (r-hFSH) and recombinant human luteinizing hormone…”
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Improving onchocerciasis elimination surveillance: trials of odour baited Esperanza Window Traps to collect black fly vectors and real-time qPCR detection of Onchocerca volvulus in black fly pools by Adeleke, Monsuru A., Opara, Kenneth N., Mafuyai, Hayward B., Nwoke, Bertram Ekejiuba Bright, Surakat, Olabanji A., Akinde, Sunday B., Nwoke, Murphy, Chikezie, Friday M., Yaro, Clement A., Mmaduabuchi, Ugagu, Igbe, Michael, Makata, Emeka, Oyediran, Fatai, Anyaike, Chukwuma, Tongjura, Joseph, Hawkes, Frances, Iwalewa, Zahra O.

“…Abstract Background Entomological data for onchocerciasis surveillance relies on sampling black flies through human landing collectors in the field and…”
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Evaluating change in gonadotropin-releasing hormone agonist versus antagonist use over time in a retrospective database study of 85,052 initiated cycles over 5 years by Mottla, G.L, Richter, K.S, Hayward, B, Mahony, M.C

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Evaluating change in day of embryo transfer over time in a retrospective database study of 60,253 transfers over 5 years by Richter, K.S, Mottla, G.L, Hayward, B, Mahony, M.C

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Weighing the impact of eset versus det on live birth rates and associated multiple rates for 38,020 day 5/6 transfers in a large real-world database by Richter, K.S, Mottla, G.L, Kaplan, B, Hayward, B, Mahony, M.C

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Treatment decision trends in the infertility patient journey from 78,958 cycles in a real-world database: impact of age, diagnosis, and year of treatment by Mottla, G.L, Richter, K.S, Kaplan, B, Hayward, B, Mahony, M.C

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Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells by DiGiusto, David L, Cannon, Paula M, Holmes, Michael C, Li, Lijing, Rao, Anitha, Wang, Jianbin, Lee, Gary, Gregory, Philip D, Kim, Kenneth A, Hayward, Samuel B, Meyer, Kathleen, Exline, Colin, Lopez, Evan, Henley, Jill, Gonzalez, Nancy, Bedell, Victoria, Stan, Rodica, Zaia, John A

“…Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor…”
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Temporal changes in oocyte donor treatment regimens in a real-world analysis of a US database of 7971 donor cycles over 6.5 years by Kaplan, B, Richter, K.S, Mottla, G.L, Hayward, B, Mahony, M.C

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Change in day of embryo transfer (ET) by age and primary diagnosis in a real-world US database study of 66,051 transfers over 6.5 years by Richter, K.S, Mottla, G.L, Kaplan, B, Hayward, B, Mahony, M.C

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Evaluating pregnancy and live birth outcomes in a real-world analysis of a US database of 66,051 transfers over 6.5 years by Richter, K.S, Mottla, G.L, Kaplan, B, Hayward, B, Mahony, M.C

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Evaluating change in gonadotropin-releasing hormone analog (GnRH) use in a US real-world database study of 96,446 in vitro fertilization cycles over 6.5 years by Mottla, G.L, Richter, K.S, Kaplan, B, Hayward, B, Mahony, M.C

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Age of the Auckland Volcanic Field: a review of existing data by Lindsay, JM, Leonard, GS, Smid, ER, Hayward, BW

“…Determining magnitude-frequency relationships, a critical first step in assessing volcanic hazard, has been hampered in the Auckland Volcanic Field (AVF) by…”
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Evidence for a Holocene Climatic Optimum in the southwest Pacific: A multiproxy study by Prebble, J. G., Bostock, H. C., Cortese, G., Lorrey, A. M., Hayward, B. W., Calvo, E., Northcote, L. C., Scott, G. H., Neil, H. L.

“…The early Holocene sea surface temperature (SST) gradient across the subtropical front (STF) to the east of New Zealand was ~2°C (measured between core sites…”
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Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures by Billon, Pierre, Nambiar, Tarun S., Hayward, Samuel B., Zafra, Maria P., Schatoff, Emma M., Oshima, Koichi, Dunbar, Andrew, Breinig, Marco, Park, Young C., Ryu, Han S., Tschaharganeh, Darjus F., Levine, Ross L., Baer, Richard, Ferrando, Adolfo, Dow, Lukas E., Ciccia, Alberto

“…Genome editing technologies have transformed our ability to engineer desired genomic changes within living systems. However, detecting precise genomic…”
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Cryopreservation methods and comparison of outcomes in the human oocyte preservation experience (HOPE) Registry by Nagy, Z.P, Elliott, T, Chang, C, Hayward, B, Mahony, M.C

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