Search Results - "Haytko, Peter"

A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors by Moores, Sheri L, Chiu, Mark L, Bushey, Barbara S, Chevalier, Kristen, Luistro, Leopoldo, Dorn, Keri, Brezski, Randall J, Haytko, Peter, Kelly, Thomas, Wu, Sheng-Jiun, Martin, Pauline L, Neijssen, Joost, Parren, Paul W H I, Schuurman, Janine, Attar, Ricardo M, Laquerre, Sylvie, Lorenzi, Matthew V, Anderson, G Mark

“…Non-small cell lung cancers (NSCLC) with activating EGFR mutations become resistant to tyrosine kinase inhibitors (TKI), often through second-site mutations in…”
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A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody by Glantschnig, Helmut, Scott, Kevin, Hampton, Richard, Wei, Nan, McCracken, Paul, Nantermet, Pascale, Zhao, Jing Z, Vitelli, Salvatore, Huang, Lingyi, Haytko, Peter, Lu, Ping, Fisher, John E, Sandhu, Punam, Cook, Jacquelynn, Williams, Donald, Strohl, William, Flores, Osvaldo, Kimmel, Donald, Wang, Fubao, An, Zhiqiang

“…Genetic studies have linked both osteoporotic and high bone mass phenotypes to low-density lipoprotein receptor-related proteins (LRP4, LRP5, and LRP6). LRPs…”
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IgG2m4, an engineered antibody isotype with reduced Fc function by An, Zhiqiang, Forrest, Gail, Moore, Renee, Cukan, Michael, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Zhao, Jing Zhang, Lu, Ping, Hua, Jin, Gibson, Christopher R., Harvey, Barrett R., Montgomery, Donna, Zaller, Dennis, Wang, Fubao, Strohl, William

“…The Fc region of an antibody mediates effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity…”
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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S] by Ni, Yan G., Di Marco, Stefania, Condra, Jon H., Peterson, Laurence B., Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A., Rosa, Ray, Cummings, Richard T., Wood, Dana D., Liu, Xiaomei, Bottomley, Matthew J., Shen, Xun, Cubbon, Rose M., Wang, Sheng-ping, Johns, Douglas G., Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J., Sparrow, Carl P., Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

“…Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We…”
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Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41 by Montgomery, Donna L., Wang, Ying-Jie, Hrin, Renee, Luftig, Micah, Su, Bin, Miller, Michael D., Wang, Fubao, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Condra, Jon, Liu, Xiaomei, Hampton, Richard, Carfi, Andrea, Pessi, Antonello, Bianchi, Elisabetta, Joyce, Joseph, Lloyd, Chris, Geleziunas, Romas, Bramhill, David, King, Vicki M., Finnefrock, Adam C., Strohl, William, An, Zhiqiang

“…The human D5 monoclonal antibody binds to the highly conserved hydrophobic pocket on the N-terminal heptad repeat (NHR) trimer of HIV-1 gp41 and exhibits…”
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An efficient process of generating bispecific antibodies via controlled Fab-arm exchange using culture supernatants by Paul, Suparna, Connor, Judy, Nesspor, Tom, Haytko, Peter, Boakye, Ken, Chiu, Mark L., Jiang, Haiyan

“…Bispecific antibody generation is actively pursued for therapeutic and research antibody development. Although there are multiple strategies for generating…”
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PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo by Ni, Yan G, Di Marco, Stefania, Condra, Jon H, Peterson, Laurence B, Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A, Rosa, Ray, Cummings, Richard T, Wood, Dana D, Liu, Xiaomei, Bottomley, Matthew J, Shen, Xun, Cubbon, Rose M, Wang, Sheng-ping, Johns, Douglas G, Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J, Sparrow, Carl P, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

“…Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We…”
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Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo by Glantschnig, Helmut, Hampton, Richard A., Lu, Ping, Zhao, Jing Z., Vitelli, Salvatore, Huang, Lingyi, Haytko, Peter, Cusick, Tara, Ireland, Cheryl, Jarantow, Stephen W., Ernst, Robin, Wei, Nan, Nantermet, Pascale, Scott, Kevin R., Fisher, John E., Talamo, Fabio, Orsatti, Laura, Reszka, Alfred A., Sandhu, Punam, Kimmel, Donald, Flores, Osvaldo, Strohl, William, An, Zhiqiang, Wang, Fubao

“…Wnt/LRP5 signaling is a central regulatory component of bone formative and resorptive activities, and the pathway inhibitor DKK1 is a suppressor of bone…”
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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors by Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E, Arnold, Beth A, Toner, Timothy J, Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T, Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frederic, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R, Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N, Franlin, Laura L, Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J, Audoly, Laurent P, Aster, Jon C, Blacklow, Stephen C, Huber, Hans E

“…Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other…”
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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes by Zhang, Liwen, McCabe, Timothy, Condra, Jon H, Ni, Yan G, Peterson, Laurence B, Wang, Weirong, Strack, Alison M, Wang, Fubao, Pandit, Shilpa, Hammond, Holly, Wood, Dana, Lewis, Dale, Rosa, Ray, Mendoza, Vivienne, Cumiskey, Anne Marie, Johns, Douglas G, Hansen, Barbara C, Shen, Xun, Geoghagen, Neil, Jensen, Kristian, Zhu, Lei, Wietecha, Karol, Wisniewski, Douglas, Huang, Lingyi, Zhao, Jing Zhang, Ernst, Robin, Hampton, Richard, Haytko, Peter, Ansbro, Frances, Chilewski, Shannon, Chin, Jayne, Mitnaul, Lyndon J, Pellacani, Andrea, Sparrow, Carl P, An, Zhiqiang, Strohl, William, Hubbard, Brian, Plump, Andrew S, Blom, Daniel, Sitlani, Ayesha

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20…”
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Abstract DDT01-03: Discovery and preclinical pharmacology of JNJ-61186372: A novel bispecific antibody targeting EGFR and cMET by Moores, Sheri L., Chiu, Mark, Bushey, Barbara, Chevalier, Kristen, Haytko, Peter, Neijssen, Joost, Parren, Paul, Schuurman, Janine, Anderson, Mark, Attar, Ricardo, Kramer, Robert, Lorenzi, Matthew V.

“…Abstract NSCLC with activating mutations in the EGFR gene are associated with high response rates to EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib…”
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Abstract B241: Bispecific antibody targeting EGFR and cMet demonstrates superior activity compared to the combination of single pathway inhibitors by Moores, Sheri, Chiu, Mark, Bushey, Barbara, Chevalier, Kristen, Chin, Diana, Chippari, Susan, Haytko, Peter, McCabe, Frank, Neijssen, Joost, Parren, Paul, Schuurman, Janine, Wu, Sam, Attar, Ricardo, Anderson, Mark

“…Abstract Many tumors respond initially to targeted therapy, only to develop resistance over time thereby allowing the tumors to progress. In patients treated…”
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Improving consistency of cell-based assays by using division-arrested cells by Fursov, Natalie, Cong, Mei, Federici, Mark, Platchek, Michael, Haytko, Peter, Tacke, Roland, Livelli, Thomas, Zhong, Zhong

“…In this article we describe the use of division-arrested cells for cell-based assays designed for high-throughput screening. Cells are the most critical and…”
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