Search Results - "Hayter, Laura"

Prodrug thiamine analogs as inhibitors of the enzyme transketolase by Le Huerou, Yvan, Gunawardana, Indrani, Thomas, Allen A., Boyd, Steven A., de Meese, Jason, deWolf, Walter, Gonzales, Steven S., Han, May, Hayter, Laura, Kaplan, Tomas, Lemieux, Christine, Lee, Patrice, Pheneger, Jed, Poch, Gregory, Romoff, Todd T., Sullivan, Francis, Weiler, Solly, Wright, S. Kirk, Lin, Jie

“…Synthesis of prodrugs of the transketolase inhibitor 5a and their evaluation in murine pharmacokinetic and pharmacodynamic models. Transketolase, a key enzyme…”
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Identification and characterization of a potent and selective antagonist of the prostaglandin D2 receptor (94.23) by Eberhardt, Christine, Wright, Dale, Gomez, Anna, Cook, Adam, Doherty, George, Corrette, Christopher, Hunt, Kevin, Clark, Christopher, Kim, Ganghyeok, Romoff, Todd, Delisle, Kirk, Hayter, Laura, Neale, Jason, Dean, Brian, Chantry, David, Carter, Laura, Burgess, Laurence E

“…Abstract Prostaglandin D2 (PGD2) is a potent lipid mediator released from activated mast cells during allergic responses which exerts its pro-inflammatory…”
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ARRY-429520, a KSP Inhibitor with Efficacy in Animal Models of Solid and Liquid Tumors by Woessner, Rich, Corrette, Chris, Allen, Shelley, Hans, Jeremy, Zhao, Qian, Aicher, Tom, Lyssikatos, Joe, Robinson, John, Poch, Greg, Hayter, Laura, Cox, April, Lee, Patrice, Winkler, James, Koch, Kevin, Wallace, Eli

“…Kinesins are eukaryotic microtubule-associated motor proteins. One of these, kinesin spindle protein (KSP) is a mitotic-specific kinesin that plays a key role…”
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