Search Results - "Haystead, Timothy A. J."

Hsp90, an unlikely ally in the war on cancer by Barrott, Jared J., Haystead, Timothy A. J.

“…On the surface heat shock protein 90 (Hsp90) is an unlikely drug target for the treatment of any disease, let alone cancer. Hsp90 is highly conserved and…”
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice by Scarneo, Scott A, Eibschutz, Liesl S, Bendele, Phillip J, Yang, Kelly W, Totzke, Juliane, Hughes, Philip, Fox, David A, Haystead, Timothy A J

“…To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II…”
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Death‐associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries by Turner, Sara R., Al‐Ghabkari, Abdulhameed, Carlson, David A., Chappellaz, Mona, Sutherland, Cindy, Haystead, Timothy A. J., Cole, William C., MacDonald, Justin A.

“…New Findings What is the central question of this study? DAPK3 contributes to the Ca2+‐sensitization of vascular smooth muscle contraction: does this protein…”
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Molecular Biologist's Guide to Proteomics by GRAVES, Paul R, HAYSTEAD, Timothy A. J

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression of membrane Hsp90 is a molecular signature of T cell activation by Scarneo, Scott A., Smith, Aaron P., Favret, Jacob, O’Connell, Robert, Pickeral, Joy, Yang, Kelly W., Ferrari, Guido, Loiselle, David R., Hughes, Philip F., Kulkarni, Manjusha M., Gargesha, Madhusudhana, Scott, Bryan, Roy, Debashish, Haynes, Barton F., Kwiek, Jesse J., Haystead, Timothy A. J.

“…Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two…”
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Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor by Carlson, David A, Franke, Aaron S, Weitzel, Douglas H, Speer, Brittany L, Hughes, Philip F, Hagerty, Laura, Fortner, Christopher N, Veal, James M, Barta, Thomas E, Zieba, Bartosz J, Somlyo, Avril V, Sutherland, Cindy, Deng, Jing Ti, Walsh, Michael P, MacDonald, Justin A, Haystead, Timothy A. J

“…DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases that regulate programmed cell death and phosphorylation of non-muscle…”
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role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction by Borman, Meredith A, Freed, Tiffany A, Haystead, Timothy A. J, MacDonald, Justin A

“…In this study, we provide further insight into the contribution of the smoothelin-like 1 (SMTNL1) calponin homology (CH)-domain on myosin light chain…”
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TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases by Totzke, Juliane, Scarneo, Scott A., Yang, Kelly W., Haystead, Timothy A. J.

“…Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and…”
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Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion by Scarneo, Scott A., Mansourati, Antoine, Eibschutz, Liesl S., Totzke, Juliane, Roques, Jose R., Loiselle, David, Carlson, David, Hughes, Philip, Haystead, Timothy A. J.

“…Immune challenge of invading macrophages at sites of infection is associated with release of TNF, which triggers a local cytokine storm as part of the normal…”
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Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle by Wooldridge, Anne A., Fortner, Christopher N., Lontay, Beata, Akimoto, Takayuki, Neppl, Ronald L., Facemire, Carie, Datto, Michael B., Kwon, Ashley, McCook, Everett, Li, Ping, Wang, Shiliang, Thresher, Randy J., Miller, Sara E., Perriard, Jean-Claude, Gavin, Timothy P., Hickner, Robert C., Coffman, Thomas M., Somlyo, Avril V., Yan, Zhen, Haystead, Timothy A.J.

“…In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The…”
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Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers by Kaneko, Kensuke, Acharya, Chaitanya R, Nagata, Hiroshi, Yang, Xiao, Hartman, Zachary Conrad, Hobeika, Amy, Hughes, Philip F, Haystead, Timothy A J, Morse, Michael A, Lyerly, Herbert Kim, Osada, Takuya

“…BackgroundWe previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel…”
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A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle by MacDonald, Justin A, Sutherland, Cindy, Carlson, David A, Bhaidani, Sabreena, Al-Ghabkari, Abdulhameed, Swärd, Karl, Haystead, Timothy A J, Walsh, Michael P

“…A novel inhibitor of zipper-interacting protein kinase (ZIPK) was used to examine the involvement of ZIPK in the regulation of smooth muscle contraction…”
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Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling by Turner, Sara R., Chappellaz, Mona, Popowich, Brittany, Wooldridge, Anne A., Haystead, Timothy A. J., Cole, William C., MacDonald, Justin A.

“…The role of the smoothelin-like 1 (SMTNL1) protein in mediating vascular smooth muscle contractile responses to intraluminal pressure was examined in…”
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An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target by Howe, Matthew K, Speer, Brittany L, Hughes, Philip F, Loiselle, David R, Vasudevan, Subhash, Haystead, Timothy A J

“…An estimated three billion people are at risk of Dengue virus (DENV) infection worldwide and there are currently no approved therapeutic interventions for DENV…”
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Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension by Sparks, Matthew A, Parsons, Kelly K, Stegbauer, Johannes, Gurley, Susan B, Vivekanandan-Giri, Anuradha, Fortner, Christopher N, Snouwaert, Jay, Raasch, Eric W, Griffiths, Robert C, Haystead, Timothy A.J, Le, Thu H, Pennathur, Subramaniam, Koller, Beverly, Coffman, Thomas M

“…Vascular injury and remodeling are common pathological sequelae of hypertension. Previous studies have suggested that the renin-angiotensin system acting…”
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Kinetic Mechanism of Quinone Oxidoreductase 2 and Its Inhibition by the Antimalarial Quinolines by Kwiek, Jesse J, Haystead, Timothy A. J, Rudolph, Johannes

“…Quinone oxidoreductase 2 (QR2) purified from human red blood cells was recently shown to be a potential target of the quinoline antimalarial compounds [Graves…”
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Discovery of novel targets of quinoline drugs in the human purine binding proteome by Graves, Paul R, Kwiek, Jesse J, Fadden, Patrick, Ray, Rupa, Hardeman, Klaas, Coley, Andrew M, Foley, Michael, Haystead, Timothy A J

“…The quinolines have been used in the treatment of malaria, arthritis, and lupus for many years, yet the precise mechanism of their action remains unclear. In…”
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A highly selective Hsp90 affinity chromatography resin with a cleavable linker by Hughes, Philip F., Barrott, Jared J., Carlson, David A., Loiselle, David R., Speer, Brittany L., Bodoor, Khaldon, Rund, Lauretta A., Haystead, Timothy A.J.

“…Over 200 proteins have been identified that interact with the protein chaperone Hsp90, a recognized therapeutic target thought to participate in non-oncogene…”
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ROCK1 Phosphorylates and Activates Zipper-interacting Protein Kinase by Hagerty, Laura, Weitzel, Douglas H., Chambers, Jenica, Fortner, Christopher N., Brush, Matthew H., Loiselle, David, Hosoya, Hiroshi, Haystead, Timothy A.J.

“…Zipper-interacting protein kinase (ZIPK) regulates Ca2+-independent phosphorylation of both smooth muscle (to regulate contraction) and non-muscle myosin (to…”
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Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle by Borman, Meredith A, MacDonald, Justin A, Haystead, Timothy A J

“…Zipper-interacting protein kinase (ZIPK) is a serine-threonine kinase that has been implicated in Ca2+-independent myosin II phosphorylation and contractile…”
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