Search Results - "Hays, S.M."

Biomonitoring equivalents: A screening approach for interpreting biomonitoring results from a public health risk perspective by Hays, S.M., Becker, R.A., Leung, H.W., Aylward, L.L., Pyatt, D.W.

“…Advances in both sensitivity and specificity of analytical chemistry have made it possible to quantify substances in human biological specimens, such as blood,…”
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Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium by Kirman, C.R., Hays, S.M., Aylward, L.L., Suh, M., Harris, M.A., Thompson, C.M., Haws, L.C., Proctor, D.M.

“…► A PBPK model was developed for oral Cr in rodents that includes the GI tract. ► Target tissue Cr data were collected in rodents exposed to Cr(VI) for 90days…”
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Physiologically based pharmacokinetic model for humans orally exposed to chromium by Kirman, C.R., Aylward, L.L., Suh, M., Harris, M.A., Thompson, C.M., Haws, L.C., Proctor, D.M., Lin, S.S., Parker, W., Hays, S.M.

“…•Human gastric fluid samples were collected to measure Cr(VI) reduction.•Cr(VI) reduction is pH-dependent, mixed second order, and capacity limited.•A human…”
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Future uses of biomonitoring equivalents and toxicokinetics data in risk assessment by Hays, S.M.

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Derivation of endogenous equivalent values to support risk assessment and risk management decisions for an endogenous carcinogen: Ethylene oxide by Kirman, C.R., Hays, S.M.

“…An approach is presented for ethylene oxide (EO) to derive endogenous equivalent (EE) values, which are endogenous levels normally found within the body…”
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Grouping of PFAS for human health risk assessment: Findings from an independent panel of experts by Anderson, J.K., Brecher, R.W., Cousins, I.T., DeWitt, J., Fiedler, H., Kannan, K., Kirman, C.R., Lipscomb, J., Priestly, B., Schoeny, R., Seed, J., Verner, M., Hays, S.M.

“…An expert panel was convened to provide insight and guidance on per- and polyfluoroalkyl substances (PFAS) grouping for the purposes of protecting human health…”
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Science peer review for the 21st century: Assessing scientific consensus for decision-making while managing conflict of interests, reviewer and process bias by Kirman, C.R., Simon, T.W., Hays, S.M.

“…Science peer review plays an important role in the advancement and acceptance of scientific information, particularly when used to support decision-making. A…”
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Use of biomarker data and metabolite relative potencies to support derivation of noncancer reference values based on the reproductive and developmental toxicity effects of 1,3-butadiene by Kirman, C.R., North, C.M., Tretyakova, N.Y., Erraguntla, N., Shen, H., Hays, S.M.

“…Subchronic and chronic reference values (RfVs) were derived for 1,3-butadiene (BD) based upon its ability to cause reproductive and developmental effects…”
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Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel by Kirman, C.R., Boogaard, P.J., Bus, J.S., Dellarco, V.L., Shao, K., Stern, B.R., Hays, S.M.

“…A panel of toxicology, mode of action (MOA), and cancer risk assessment experts was engaged to derive no-significant-risk-levels (NSRLs) for three lower…”
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A perspective on In vitro developmental neurotoxicity test assay results: An expert panel review by Juberg, D.R., Fox, D.A., Forcelli, P.A., Kacew, S., Lipscomb, J.C., Saghir, S.A., Sherwin, C.M., Koenig, C.M., Hays, S.M., Kirman, C.R.

“…For decades, there has been increasing concern about the potential developmental neurotoxicity (DNT) associated with chemicals. Regulatory agencies have…”
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Cancer weight of evidence for three lower acrylates: Conclusions and recommendations from an expert panel by Kirman, C.R., Boogaard, P.J., Bus, J.S., Dellarco, V.L., DePass, L.R., Stern, B.R., Hays, S.M.

“…An international panel of experts was engaged to assess the cancer weight of evidence (WOE) for three lower acrylates: methyl acrylate, ethyl acrylate, and…”
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Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations by Kirman, C.R., Suh, M., Proctor, D.M., Hays, S.M.

“…A physiologically based pharmacokinetic (PBPK) model for hexavalent chromium [Cr(VI)] in mice, rats, and humans developed previously (Kirman et al., 2012,…”
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Interpreting biomonitoring data for 2,4-dichlorophenoxyacetic acid: Update to Biomonitoring Equivalents and population biomonitoring data by Aylward, L.L., Hays, S.M.

“…Urinary biomonitoring data for 2,4-dichlorophenoxyacetic acid (2,4-D) reflect aggregate population exposures to trace 2,4-D residues in diet and the…”
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An evaluation of reproductive toxicity studies and data interpretation of N-methylpyrrolidone for risk assessment: An expert panel review by Kirman, C.R., Sonawane, B.R., Seed, J.G., Azu, N.O., Barranco, W.T., Hamilton, W.R., Stedeford, T.J., Hays, S.M.

“…An expert panel was assembled to evaluate reproductive toxicology study data and their application to health risk assessment to provide input on the data…”
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Biomonitoring Equivalents for interpretation of urinary fluoride by Aylward, L.L., Hays, S.M., Vezina, A., Deveau, M., St-Amand, A., Nong, A.

“…•Fluoride exposures can be effectively quantified via urinary biomonitoring.•Biomonitoring Equivalents (BE) are levels consistent with exposure guidance…”
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Biomonitoring Equivalents for cyanide by Kirman, C.R., Belknap, A.M., Webster, A.F., Hays, S.M.

“…Exposure to cyanide is widespread in human populations due to a variety of natural and anthropogenic sources. The potential health risks of excess cyanide…”
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Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine by Kirman, C.R., Hughes, B., Becker, R.A., Hays, S.M.

“…Diethanolamine (DEA) has been found to produce liver and kidney tumors in mice following lifetime dermal exposures. Data regarding the mode of action by which…”
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Corrigendum to “Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium” [Chem Biol Interact 2012;200:45–64] by Kirman, C.R., Hays, S.M., Aylward, L.L., Suh, M., Harris, M.A., Thompson, C.M., Haws, L.C., Proctor, D.M.

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Introduction to the Biomonitoring Equivalents Pilot Project: Development of guidelines for the derivation and communication of Biomonitoring Equivalents by Hays, S.M., Aylward, L.L., LaKind, J.S.

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Pine needles--a hot, new commodity by Hays, S.M

“…Catalino Blanche suggests that pine needles be harvested and sold, since they are a hot commodity among landscapers and builders. Pine straw harvesting is very…”
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