Genotoxic potential of selected medicinal plant extracts in human whole blood cultures

Introduction: Many plant-derived products despite wide usage are not scientifically evaluated for their safety and efﬁcacy. Therefore, in the present study, we aimed to evaluate the cytotoxic and genotoxic activities of Polygonum aviculare L., Equisetum arvense L., Plantago lanceolata L. and Artemis...

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Bibliographic Details
Published in:	Journal of herbmed pharmacology Vol. 8; no. 2; pp. 160 - 162
Main Authors:	Harutyunyan, Karina, Balayan, Karine, Tadevosyan, Gohar, Hayrapetyan, Manush, Musayelyan, Ruzanna, Grigoryan, Ruzanna, Khondkaryan, Lusine, Sarkisyan, Natalya, Babayan, Nelly
Format:	Journal Article
Language:	English
Published:	Shahrekord University of Medical Sciences 01-03-2019
Subjects:	Cell viability Genotoxicity Herbal medicine Leaf extracts Medicinal plants Micronucleus
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Summary:	Introduction: Many plant-derived products despite wide usage are not scientifically evaluated for their safety and efﬁcacy. Therefore, in the present study, we aimed to evaluate the cytotoxic and genotoxic activities of Polygonum aviculare L., Equisetum arvense L., Plantago lanceolata L. and Artemisia absinthium L. ethanolic extracts in human white blood cells. Methods: Cell viability was assayed by trypan blue exclusion method, while the genotoxicity was tested by cytokinesis-block micronucleus (CBMN) assay upon cells stimulation with noncytotoxic concentrations of the plant extracts. Results: None of the plant extracts showed high cytotoxic activity. At the same time, only extract of P. lanceolata did not present any mutagenic activity, while E. arvense, P. aviculare and A. absinthium were clearly genotoxic. Conclusion: Caution is advice in the case of long-term use of E. arvense, P. aviculare and A. absinthium herbal medicines by population.
ISSN:	2345-5004 2345-5004
DOI:	10.15171/jhp.2019.25