Search Results - "Haynes, Richard K."

In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells by Dwivedi, Anupma, PhD, Mazumder, Anisha, PhD, du Plessis, Lissinda, PhD, du Preez, Jan L., PhD, Haynes, Richard K., PhD, du Plessis, Jeanetta, PhD

“…Abstract Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also…”
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The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success by van Staden, Daniélle, Haynes, Richard K, Viljoen, Joe M

“…Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing…”
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The Science of Selecting Excipients for Dermal Self-Emulsifying Drug Delivery Systems by van Staden, Daniélle, Haynes, Richard K, Viljoen, Joe M

“…Self-emulsification is considered a formulation technique that has proven capacity to improve oral drug delivery of poorly soluble drugs by advancing both…”
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An in vitro ADME and in vivo Pharmacokinetic Study of Novel TB-Active Decoquinate Derivatives by Tanner, Lloyd, Haynes, Richard K, Wiesner, Lubbe

“…Tuberculosis (TB) is currently the leading cause of mortality due to an infectious disease, despite the existence of multiple effective first-line and…”
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The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria by Watson, Daniel J., Laing, Lizahn, Beteck, Richard M., Gibhard, Liezl, Haynes, Richard K., Wiesner, Lubbe

“…The emergence of Plasmodium falciparum ( Pf ) parasite strains tolerant of the artemisinin component and resistant to the other drug component in artemisinin…”
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Recent progress in the development of anti-malarial quinolones by Beteck, Richard M, Smit, Frans J, Haynes, Richard K, N'Da, David D

“…Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities due to malaria from one million to less…”
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Accumulation of TB-Active Compounds in Murine Organs Relevant to Infection by Mycobacterium tuberculosis by Tanner, Lloyd, Haynes, Richard K., Wiesner, Lubbe

“…Tuberculosis (TB), the leading cause of death due to an infectious agent, requires prolonged and costly drug treatments. With the rise in incidence of MDR and…”
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Assessment of the Activity of Decoquinate and Its Quinoline- O -Carbamate Derivatives against Toxoplasma gondii In Vitro and in Pregnant Mice Infected with T. gondii Oocysts by Ramseier, Jessica, Imhof, Dennis, Anghel, Nicoleta, Hänggeli, Kai, Beteck, Richard M, Balmer, Vreni, Ortega-Mora, Luis-Miguel, Sanchez-Sanchez, Roberto, Ferre, Ignacio, Haynes, Richard K, Hemphill, Andrew

“…The quinolone decoquinate (DCQ) is widely used in veterinary practice for the treatment of bacterial and parasitic infections, most notably, coccidiosis in…”
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Adapting Clofazimine for Treatment of Cutaneous Tuberculosis by Using Self-Double-Emulsifying Drug Delivery Systems by van Staden, Daniélle, Haynes, Richard K, Viljoen, Joe M

“…Although chemotherapeutic treatment regimens are currently available, and considerable effort has been lavished on the development of new drugs for the…”
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Anticancer properties of distinct antimalarial drug classes by Hooft van Huijsduijnen, Rob, Guy, R Kiplin, Chibale, Kelly, Haynes, Richard K, Peitz, Ingmar, Kelter, Gerhard, Phillips, Margaret A, Vennerstrom, Jonathan L, Yuthavong, Yongyuth, Wells, Timothy N C

“…We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines…”
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Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins by Watson, Daniel J, Laing, Lizahn, Petzer, Jacobus P, Wong, Ho Ning, Parkinson, Christopher J, Wiesner, Lubbe, Haynes, Richard K

“…Efforts to develop new artemisinin triple combination therapies effective against artemisinin-tolerant strains of based on rational combinations comprising…”
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A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2) by Coghi, Paolo, Yang, Li Jun, Ng, Jerome P L, Haynes, Richard K, Memo, Maurizio, Gianoncelli, Alessandra, Wong, Vincent Kam Wai, Ribaudo, Giovanni

“…Host cell invasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by the interaction of the viral spike protein (S) with human…”
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Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model by DUNAY, Ildiko R, WING CHI CHAN, HAYNES, Richard K, SIBLEY, L. David

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs by Wong, Ho Ning, Lewies, Angélique, Haigh, Michaela, Viljoen, Joe M., Wentzel, Johannes F., Haynes, Richard K., du Plessis, Lissinda H.

“…The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy…”
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Facile Preparation of N -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities by Wu, Yuet, Parapini, Silvia, Williams, Ian D, Misiano, Paola, Wong, Ho Ning, Taramelli, Donatella, Basilico, Nicoletta, Haynes, Richard K

“…According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar…”
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Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation by Müller, Joachim, Schlange, Carling, Heller, Manfred, Uldry, Anne-Christine, Braga-Lagache, Sophie, Haynes, Richard K., Hemphill, Andrew

“…The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of…”
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The Case for Development of 11-Aza-artemisinins for Malaria by Harmse, Rozanne, Wong, Ho Ning, Smit, Frans, Haynes, Richard K, N'Da, David D

“…The current treatment regimens for uncomplicated malaria comprise an artemisinin in combination with another drug (ACT). However, the recent emergence of…”
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In Vitro versus in Mice: Efficacy and Safety of Decoquinate and Quinoline- O -Carbamate Derivatives against Experimental Infection with Neospora caninum Tachyzoites by Ramseier, Jessica, Imhof, Dennis, Hänggeli, Kai Pascal Alexander, Anghel, Nicoleta, Boubaker, Ghalia, Beteck, Richard M, Ortega-Mora, Luis-Miguel, Haynes, Richard K, Hemphill, Andrew

“…The effects of decoquinate (DCQ) and three -quinoline-carbamate-derivatives were investigated using human foreskin fibroblasts (HFF) infected with tachyzoites…”
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Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue by Ng, Jerome P. L., Han, Yu, Yang, Li Jun, Birkholtz, Lyn-Marie, Coertzen, Dina, Wong, Ho Ning, Haynes, Richard K., Coghi, Paolo, Wong, Vincent Kam Wai

“…Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 ( Artemisia annua ) and its derivatives are used for treatment of malaria. With…”
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Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria by Waknine-Grinberg, Judith H, Even-Chen, Simcha, Avichzer, Jasmine, Turjeman, Keren, Bentura-Marciano, Annael, Haynes, Richard K, Weiss, Lola, Allon, Nahum, Ovadia, Haim, Golenser, Jacob, Barenholz, Yechezkel

“…Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in…”
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