Search Results - "Haynes, Laura M."

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape by Huttinger, Zachary M., Haynes, Laura M., Yee, Andrew, Kretz, Colin A., Holding, Matthew L., Siemieniak, David R., Lawrence, Daniel A., Ginsburg, David

“…The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases…”
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Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity by Wood, Jeremy P., Silveira, Jay R., Maille, Nicole M., Haynes, Laura M., Tracy, Paula B.

“…Effective hemostasis relies on the timely formation of α-thrombin via prothrombinase, a Ca2+-dependent complex of factors Va and Xa assembled on the activated…”
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Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition by Haynes, Laura M., Huttinger, Zachary M., Yee, Andrew, Kretz, Colin A., Siemieniak, David R., Lawrence, Daniel A., Ginsburg, David

“…Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily of proteins, is unique among serine protease inhibitors for…”
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Prothrombin Activation by Platelet-associated Prothrombinase Proceeds through the Prethrombin-2 Pathway via a Concerted Mechanism by Haynes, Laura M., Bouchard, Beth A., Tracy, Paula B., Mann, Kenneth G.

“…The protease α-thrombin is a key enzyme of the coagulation process as it is at the cross-roads of both the pro- and anti-coagulant pathways. The main source of…”
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Probing the Dynamics of Clot-Bound Thrombin at Venous Shear Rates by Haynes, Laura M., Orfeo, Thomas, Mann, Kenneth G., Everse, Stephen J., Brummel-Ziedins, Kathleen E.

“…In closed system models of fibrin formation, exosite-mediated thrombin binding to fibrin contributes to clot stability and is resistant to inhibition by…”
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O−H Stretch Overtone Excitation in Methyl and Ethyl Hydroperoxides by Homitsky, Sarah C, Dragulin, Sonia M, Haynes, Laura M, Hsieh, Shizuka

“…We use laser photoacoustic spectroscopy to obtain vibrational overtone spectra in the regions of four and five quanta of O−H stretch (4νOH and 5νOH) for…”
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Rivaroxaban Delivery and Reversal at a Venous Flow Rate by Haynes, Laura M, Orfeo, Thomas, Mann, Kenneth G

“…OBJECTIVE—Rivaroxaban is an oral anticoagulant that directly targets both free factor Xa and factor Xa in complex with its protein cofactor, factor Va, in the…”
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Dilutional Control of Prothrombin Activation at Physiologically Relevant Shear Rates by Haynes, Laura M., Dubief, Yves C., Orfeo, Thomas, Mann, Kenneth G.

“…The generation of proteolyzed prothrombin species by preassembled prothrombinase in phospholipid-coated glass capillaries was studied at physiologic shear…”
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Membrane Binding Events in the Initiation and Propagation Phases of Tissue Factor-initiated Zymogen Activation under Flow by Haynes, Laura M., Dubief, Yves C., Mann, Kenneth G.

“…This study investigates the dynamics of zymogen activation when both extrinsic tenase and prothrombinase are assembled on an appropriate membrane. Although the…”
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Hemodilution and Endothelial Cell Regulation of Whole Blood Coagulation by Orfeo, Thomas, Gissel, Matthew, Haynes, Laura M, Pusateri, Anthony, Mann, Kenneth G, Brummel-Ziedins, Kathleen E

“…Abstract Background Beyond localized damage to the circulatory system and surrounding tissue, trauma stresses endothelial cells throughout the vasculature,…”
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Abstract 133: Engineering Plasminogen Activator Inhibitor-1 Variants With Novel Protease Inhibitor Activity by Haynes, Laura M, Holding, Matthew L, Trost, Elise, DiGiovanni, Hannah, Siemieniak, David, Ginsburg, David

“…Abstract only Plasminogen activator inhibitor-1 (PAI-1) is a member of the serine protease inhibitor, or SERPIN, protein superfamily that canonically inhibits…”
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Mathematical models of fibrin polymerization: past, present, and future by Nelson, Anna C., Kelley, Michael A., Haynes, Laura M., Leiderman, Karin

“…Blood clotting is a complex biochemical and biophysical process that leads to the formation of a stabilizing fibrin mesh. Fibrin polymerization is a necessary,…”
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The effects of flow on the activation of bovine prothrombin by prothrombinase at physiologically relevant shear rates by Haynes, Laura M., Dubief, Yves, Orfeo, Thomas, Mann, Kenneth G.

“…The generation of thrombin by preassembled prothrombinase on phospholipid coated capillaries was studied under laminar flow at physiologic shear rates…”
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