Search Results - "Haynes, Ken"

Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organism by Usher, Jane, Haynes, Ken

“…Drug resistance is a rapidly emerging concern, thus prompting the development of novel therapeutics or combinatorial therapy. Currently, combinatorial therapy…”
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Nitrosative and oxidative stress responses in fungal pathogenicity by Brown, Alistair JP, Haynes, Ken, Quinn, Janet

“…Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees…”
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Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes by Schwarzmüller, Tobias, Ma, Biao, Hiller, Ekkehard, Istel, Fabian, Tscherner, Michael, Brunke, Sascha, Ames, Lauren, Firon, Arnaud, Green, Brian, Cabral, Vitor, Marcet-Houben, Marina, Jacobsen, Ilse D, Quintin, Jessica, Seider, Katja, Frohner, Ingrid, Glaser, Walter, Jungwirth, Helmut, Bachellier-Bassi, Sophie, Chauvel, Murielle, Zeidler, Ute, Ferrandon, Dominique, Gabaldón, Toni, Hube, Bernhard, d'Enfert, Christophe, Rupp, Steffen, Cormack, Brendan, Haynes, Ken, Kuchler, Karl

“…The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis, causing infections ranging from superficial to life-threatening…”
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Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection by Schrettl, Markus, Bignell, Elaine, Kragl, Claudia, Sabiha, Yasmin, Loss, Omar, Eisendle, Martin, Wallner, Anja, Arst, Jr, Herbert N, Haynes, Ken, Haas, Hubertus

“…Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity…”
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Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans by Holland, Linda M, Schröder, Markus S, Turner, Siobhán A, Taff, Heather, Andes, David, Grózer, Zsuzsanna, Gácser, Attila, Ames, Lauren, Haynes, Ken, Higgins, Desmond G, Butler, Geraldine

“…Candida parapsilosis and Candida albicans are human fungal pathogens that belong to the CTG clade in the Saccharomycotina. In contrast to C. albicans,…”
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Sub-telomere directed gene expression during initiation of invasive aspergillosis by McDonagh, Andrew, Fedorova, Natalie D, Crabtree, Jonathan, Yu, Yan, Kim, Stanley, Chen, Dan, Loss, Omar, Cairns, Timothy, Goldman, Gustavo, Armstrong-James, Darius, Haynes, Ken, Haas, Hubertus, Schrettl, Markus, May, Gregory, Nierman, William C, Bignell, Elaine

“…Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled…”
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Differences in fungal immune recognition by monocytes and macrophages: N-mannan can be a shield or activator of immune recognition by Yadav, Bhawna, Mora-Montes, Héctor M., Wagener, Jeanette, Cunningham, Iain, West, Lara, Haynes, Ken, Brown, Alistair J.P., Gow, Neil A.R.

“…[Display omitted] •Cytokine response to N-mannan mutants was dependent on the immune cell type used.•N-mannan mutants stimulated less cytokines from monocytes…”
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An integrative model of ion regulation in yeast by Ke, Ruian, Ingram, Piers J, Haynes, Ken

“…Yeast cells are able to tolerate and adapt to a variety of environmental stresses. An essential aspect of stress adaptation is the regulation of monovalent ion…”
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Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans by Komalapriya, Chandrasekaran, Kaloriti, Despoina, Tillmann, Anna T, Yin, Zhikang, Herrero-de-Dios, Carmen, Jacobsen, Mette D, Belmonte, Rodrigo C, Cameron, Gary, Haynes, Ken, Grebogi, Celso, de Moura, Alessandro P S, Gow, Neil A R, Thiel, Marco, Quinn, Janet, Brown, Alistair J P, Romano, M Carmen

“…The major fungal pathogen of humans, Candida albicans, mounts robust responses to oxidative stress that are critical for its virulence. These responses…”
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form of a trade‐off determines the response to competition by Maharjan, Ram, Nilsson, Susanna, Sung, Judy, Haynes, Ken, Beardmore, Robert E, Hurst, Laurence D, Ferenci, Tom, Gudelj, Ivana, Baalen, Minus

“…Understanding how populations and communities respond to competition is a central concern of ecology. A seminal theoretical solution first formalised by Levins…”
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Functional Characterization of a Novel Oxidative Stress Protection Protein in the Pathogenic Yeast Candida glabrata by Usher, Jane, Chaudhari, Yogesh, Attah, Victoria, Ho, Hsueh-Lui, Haynes, Ken

“…Candida species are important pathogens of humans and the fourth most commonly isolated pathogen from nosocomial blood stream infections. Although Candida…”
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The Zymoseptoria tritici ORFeome: a functional genomics community resource by Chaudhari, Yogesh, Cairns, Timothy Charles, Sidhu, Yaadwinder, Attah, Victoria, Thomas, Graham, Csukai, Michael, Talbot, Nicholas J, Studholme, David, Haynes, Ken

“…Libraries of protein-encoding sequences can be generated by identification of open reading frames (ORFs) from a genome of choice that are then assembled into…”
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Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes by Kaloriti, Despoina, Jacobsen, Mette, Yin, Zhikang, Patterson, Miranda, Tillmann, Anna, Smith, Deborah A, Cook, Emily, You, Tao, Grimm, Melissa J, Bohovych, Iryna, Grebogi, Celso, Segal, Brahm H, Gow, Neil A R, Haynes, Ken, Quinn, Janet, Brown, Alistair J P

“…Immune cells exploit reactive oxygen species (ROS) and cationic fluxes to kill microbial pathogens, such as the fungus Candida albicans. Yet, C. albicans is…”
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Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages by Kasper, Lydia, Seider, Katja, Gerwien, Franziska, Allert, Stefanie, Brunke, Sascha, Schwarzmüller, Tobias, Ames, Lauren, Zubiria-Barrera, Cristina, Mansour, Michael K, Becken, Ulrike, Barz, Dagmar, Vyas, Jatin M, Reiling, Norbert, Haas, Albert, Haynes, Ken, Kuchler, Karl, Hube, Bernhard

“…Candida glabrata currently ranks as the second most frequent cause of invasive candidiasis. Our previous work has shown that C. glabrata is adapted to…”
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New insights into the structure of (1→3,1→6)-β-D-glucan side chains in the Candida glabrata cell wall by Lowman, Douglas W, West, Lara J, Bearden, Daniel W, Wempe, Michael F, Power, Trevor D, Ensley, Harry E, Haynes, Ken, Williams, David L, Kruppa, Michael D

“…β-Glucan is a (1→3)-β-linked glucose polymer with (1→6)-β-linked side chains and a major component of fungal cell walls. β-Glucans provide structural integrity…”
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A Host-Pathogen Interaction Screen Identifies ada2 as a Mediator of Candida glabrata Defenses Against Reactive Oxygen Species by Kounatidis, Ilias, Ames, Lauren, Mistry, Rupal, Ho, Hsueh-Lui, Haynes, Ken, Ligoxygakis, Petros

“…( ) forms part of the normal human gut microbiota but can cause life-threatening invasive infections in immune-compromised individuals. displays high…”
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The MNN2 gene knockout modulates the antifungal resistance of biofilms of Candida glabrata by Rodrigues, Célia Fortuna, Boas, Diana Patrícia Andrade Vilas, Haynes, Ken, Henriques, Mariana

“…Candida glabrata biofilms are recognized to have high resistance to antifungals. In order to understand the effect of mannans in the resistance profile of C…”
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The Aspergillus pH‐responsive transcription factor PacC regulates virulence by Bignell, Elaine, Negrete‐Urtasun, Susana, Calcagno, Ana Maria, Haynes, Ken, Arst, Herbert N., Rogers, Tom

“…Summary The ability of a pathogen to adapt to the host environment is usually required for the initiation of disease. Here we have investigated the importance…”
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Different Consequences of ACE2 and SWI5 Gene Disruptions for Virulence of Pathogenic and Nonpathogenic Yeasts by MacCallum, Donna M, Findon, Helen, Kenny, Claire C, Butler, Geraldine, Haynes, Ken, Odds, Frank C

“…Mutants of Candida albicans, Candida glabrata, and Saccharomyces cerevisiae with disruptions in the ACE2 gene and C. glabrata and S. cerevisiae swi5 disruption…”
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A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi by You, Tao, Ingram, Piers, Jacobsen, Mette D, Cook, Emily, McDonagh, Andrew, Thorne, Thomas, Lenardon, Megan D, de Moura, Alessandro P S, Romano, M Carmen, Thiel, Marco, Stumpf, Michael, Gow, Neil A R, Haynes, Ken, Grebogi, Celso, Stark, Jaroslav, Brown, Alistair J P

“…Saccharomyces cerevisiae senses hyperosmotic conditions via the HOG signaling network that activates the stress-activated protein kinase, Hog1, and modulates…”
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