Search Results - "Hayman, Alison R."

Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy by Hayman, Alison R.

“…Tartrate-resistant acid phosphatase (TRAP), once considered to be just a histochemical marker of osteoclasts is now recognised to be a molecule of widespread…”
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Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins by Sun, Pengling, Sleat, David E, Lecocq, Michèle, Hayman, Alison R, Jadot, Michel, Lobel, Peter

“…Most newly synthesized proteins destined for the lysosome reach this location via a specific intracellular pathway. In the Golgi, a phosphotransferase…”
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VEGF and its role in the early development of the long bone epiphysis by Allerstorfer, Doris, Longato, Stefano, Schwarzer, Christoph, Fischer‐Colbrie, Reiner, Hayman, Alison R., Blumer, Michael J. F.

“…In long bones of murine species, undisturbed development of the epiphysis depends on the generation of vascularized cartilage canals shortly after birth…”
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Tartrate‐Resistant Acid Phosphatase Knockout Mice by Hayman, Alison R, Cox, Timothy M

“…TRACP is a lysosomal enzyme found in diverse tissues, where it is expressed in dendritic cells as well as osteoclasts and macrophages. To investigate the…”
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Altered collagen in tartrate-resistant acid phosphatase (TRAP)-deficient mice: a role for TRAP in bone collagen metabolism by Roberts, Helen C, Knott, Lynda, Avery, Nicholas C, Cox, Timothy M, Evans, Martin J, Hayman, Alison R

“…Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein that is highly expressed by osteoclasts, macrophages, and dendritic cells. The enzyme…”
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Human breast cancer cell lines and tissues express tartrate-resistant acid phosphatase (TRAP) by Adams, Lisa M., Warburton, Michael J., Hayman, Alison R.

“…Tartrate-resistant acid phosphatase (TRAP) is expressed by osteoclasts, macrophages and dendritic cells. TRAP has been identified in a wide variety of tissues,…”
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Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature by Crow, Yanick J, Briggs, Tracy A, Rice, Gillian I, Daly, Sarah, Urquhart, Jill, Gornall, Hannah, Bader-Meunier, Brigitte, Baskar, Kannan, Baskar, Shankar, Baudouin, Veronique, Beresford, Michael W, Black, Graeme C M, Dearman, Rebecca J, de Zegher, Francis, Foster, Emily S, Francès, Camille, Hayman, Alison R, Hilton, Emma, Job-Deslandre, Chantal, Kulkarni, Muralidhar L, Le Merrer, Martine, Linglart, Agnes, Lovell, Simon C, Maurer, Kathrin, Musset, Lucile, Navarro, Vincent, Picard, Capucine, Puel, Anne, Rieux-Laucat, Frederic, Roifman, Chaim M, Scholl-Bürgi, Sabine, Smith, Nigel, Szynkiewicz, Marcin, Wiedeman, Alice, Wouters, Carine, Zeef, Leo A H, Casanova, Jean-Laurent, Elkon, Keith B, Janckila, Anthony, Lebon, Pierre

“…We studied ten individuals from eight families showing features consistent with the immuno-osseous dysplasia spondyloenchondrodysplasia. Of particular note was…”
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Tartrate-resistant Acid Phosphatase (Acp 5): Identification in Diverse Human Tissues and Dendritic Cells by Hayman, Alison R, Macary, Paul, Lehner, Paul J, Cox, Timothy M

“…Histochemical demonstration of tartrate-resistant acid phosphatase (TRAP) is used for the specific identification of osteoclasts. The enzyme, which we have…”
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Role of tartrate-resistant acid phosphatase (TRAP) in long bone development by Blumer, Michael J.F., Hausott, Barbara, Schwarzer, Christoph, Hayman, Alison R., Stempel, Judith, Fritsch, Helga

“…► We examined the role of the TRAP enzyme during endochondral bone formation in mice. ► TRAP does not impair vascularization as well as ossification of the…”
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Osteoclasts from Mice Deficient in Tartrate-Resistant Acid Phosphatase Have Altered Ruffled Borders and Disturbed Intracellular Vesicular Transport by Hollberg, Karin, Hultenby, Kjell, Hayman, Alison R., Cox, Timothy M., Andersson, Göran

“…Tartrate-resistant acid phosphatase (TRAP) is an enzyme highly expressed in osteoclasts (OC) and chondroclasts. As an approach to pinpoint the function of TRAP…”
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Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis by Hayman, A R, Jones, S J, Boyde, A, Foster, D, Colledge, W H, Carlton, M B, Evans, M J, Cox, T M

“…Mature osteoclasts specifically express the purple, band 5 isozyme (Acp 5) of tartrate-resistant acid phosphatase, a binuclear metalloenzyme that can generate…”
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Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice by Suter, A, Everts, V, Boyde, A, Jones, S J, Lüllmann-Rauch, R, Hartmann, D, Hayman, A R, Cox, T M, Evans, M J, Meister, T, von Figura, K, Saftig, P

“…To date, two lysosomal acid phosphatases are known to be expressed in cells of the monocyte/phagocyte lineage: the ubiquitously expressed lysosomal acid…”
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Osteoclastic Tartrate-resistant Acid Phosphatase (Acp 5): Its Localization to Dendritic Cells and Diverse Murine Tissues by Hayman, Alison R, Bune, Alison J, Bradley, John R, Rashbass, Jeremy, Cox, Timothy M

“…Tartrate-resistant acid phosphatase (TRAP) is a histochemical marker of the osteoclast. It is also characteristic of monohistiocytes, particularly alveolar…”
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TRACP Influences Th1 Pathways by Affecting Dendritic Cell Function by Esfandiari, Ehsanollah, Bailey, Michael, Stokes, Christopher R, Cox, Timothy M, Evans, Martin J, Hayman, Alison R

“…TRACP, a marker of osteoclasts, is also expressed by cells of the immune system. We identified a novel function for TRACP in the dendritic cell. DCs from TRACP…”
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Tartrate-resistant acid phosphatase: a potential target for therapeutic gold by Hayman, Alison R., Cox, Timothy M.

“…Gold compounds are disease‐modifying agents for the treatment of rheumatoid arthritis. They act on the immune system but the mechanism is not fully understood…”
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Widespread expression of tartrate‐resistant acid phosphatase (Acp 5) in the mouse embryo by HAYMAN, ALISON R., BUNE, ALISON J., COX, TIMOTHY M.

“…Tartrate‐resistant acid phosphatase (TRAP, Acp 5) is considered to be a marker of the osteoclast and studies using ‘knockout’ mice have demonstrated that TRAP…”
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Human osteoclastomas contain multiple forms of cathepsin B by Page, A E, Warburton, M J, Chambers, T J, Pringle, J A, Hayman, A R

“…During bone resorption, the osteoclast secretes hydrolytic enzymes into the sealing zone which it creates between itself and the bone surface. Since this…”
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Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K by Moran, Mary Teresa, Schofield, J. Paul, Hayman, Alison R., Shi, Guo-Ping, Young, Elisabeth, Cox, Timothy M.

“…Deficiency of lysosomal acid β-glucosidase induces glycolipid storage in the macrophages of Gaucher disease but the pathways of multisystem tissue injury and…”
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Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein secreted by baculovirus-infected insect cells by HAYMAN, A. R, COX, T. M

“…The purple phosphatases catalyze hydrolysis of phosphate esters (optimum pH approximately 5) and are resistant to inhibition by dextro-rotatory tartrate; their…”
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Tartrate-resistant acid phosphatase knockout mice : Recent advances in TRACP/PAP biochemistry, molecular biology, and clinical application by HAYMAN, Alison R, COX, Timothy M

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