Search Results - "Hayflick, Joel"

Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors by Luke, Jason J, Barlesi, Fabrice, Chung, Ki, Tolcher, Anthony W, Kelly, Karen, Hollebecque, Antoine, Le Tourneau, Christophe, Subbiah, Vivek, Tsai, Frank, Kao, Steven, Cassier, Philippe A, Khasraw, Mustafa, Kindler, Hedy L, Fang, Hua, Fan, Frances, Allaire, Kathryn, Patel, Maulik, Ye, Shiming, Chao, Debra T, Henner, William R, Hayflick, Joel S, McDevitt, Michael A, Fong, Lawrence

“…BackgroundCD40 agonist immunotherapy can potentially license antigen-presenting cells to promote antitumor T-cell activation and re-educate macrophages to…”
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Inhibition of phosphoinositide 3‐kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model by Lee, Kyung S., Lee, Ho K., Hayflick, Joel S., Lee, Yong C., Puri, Kamal D.

“…P110δ phosphoinositide 3‐kinase (PI3K) plays a pivotal role in the recruitment and activation of certain inflammatory cells. Recent findings revealed that the…”
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Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia by Sujobert, Pierre, Bardet, Valerie, Cornillet-Lefebvre, Pascale, Hayflick, Joel S., Prie, Nolwen, Verdier, Frederic, Vanhaesebroeck, Bart, Muller, Odile, Pesce, Florence, Ifrah, Norbert, Hunault-Berger, Mathilde, Berthou, Christian, Villemagne, Bruno, Jourdan, Eric, Audhuy, Bruno, Solary, Eric, Witz, Brigitte, Harousseau, Jean Luc, Himberlin, Chantal, Lamy, Thierry, Lioure, Bruno, Cahn, Jean Yves, Dreyfus, Francois, Mayeux, Patrick, Lacombe, Catherine, Bouscary, Didier

“…The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been shown to be frequently activated in blast cells from patients with acute myeloid leukemia…”
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Mechanisms and implications of phosphoinositide 3-kinase δ in promoting neutrophil trafficking into inflamed tissue by Puri, Kamal D., Doggett, Teresa A., Douangpanya, Jason, Hou, Yonghao, Tino, William T., Wilson, Tim, Graf, Thomas, Clayton, Elizabeth, Turner, Martin, Hayflick, Joel S., Diacovo, Thomas G.

“…The phosphoinositide 3-kinase (PI3K) catalytic subunit p110δ is expressed in neutrophils and is thought to play a role in their accumulation at sites of…”
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Requirement for Phosphoinositide 3-Kinase p110δ Signaling in B Cell Antigen Receptor-Mediated Antigen Presentation by Al-Alwan, Monther M., Okkenhaug, Klaus, Vanhaesebroeck, Bart, Hayflick, Joel S., Marshall, Aaron J.

“…Abstract The BCR serves to both signal cellular activation and enhance uptake and presentation of Ags by B cells; however, the intracellular signaling…”
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Tissue- and Stimulus-Dependent Role of Phosphatidylinositol 3-Kinase Isoforms for Neutrophil Recruitment Induced by Chemoattractants In Vivo by Pinho, Vanessa, de Castro Russo, Remo, Amaral, Flavio A, de Sousa, Lirlandia P, Barsante, Michele M, de Souza, Danielle G, Alves-Filho, Jose C, Cara, Denise C, Hayflick, Joel S, Rommel, Christian, Ruckle, Thomas, Rossi, Adriano G, Teixeira, Mauro M

“…PI3K plays a fundamental role in regulating neutrophil recruitment into sites of inflammation but the role of the different isoforms of PI3K remains unclear…”
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Birth and life of tissue macrophages and their migration in embryogenesis and inflammation in medaka by Grabher, Clemens, Cliffe, Adam, Miura, Kota, Hayflick, Joel, Pepperkok, Rainer, Rørth, Pernille, Wittbrodt, Joachim

“…Macrophages detecting and migrating toward sites of injury and infection represent one of the first steps in an immune response. Here we directly image…”
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A specific antagonist of the p110δ catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction by LING GENG, JIAHUAI TAN, HALLAHAN, Dennis E, HIMMELFARB, Eric, SCHUENEMAN, Aaron, NIERMANN, Ken, FU, Allie, CUNEO, Kyle, KESICKI, Edward A, TREIBERG, Jennifer, HAYFLICK, Joel S

“…Abstract The phosphatidylinositol 3′-kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell…”
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PI3-Kinase Upregulation and Involvement in Spontaneous Tone in Arteries From DOCA-Salt Rats: Is p110δ the Culprit? by Northcott, Carrie A, Hayflick, Joel S, Watts, Stephanie W

“…ABSTRACT—Increased expression of phosphoinositide 3-kinase (PI3-kinase) mediates elevated tone in the aorta from hypertensive deoxycorticosterone acetate…”
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Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility by Northcott, Carrie A, Hayflick, Joel, Watts, Stephanie W

“…SUMMARY 1. The growth enzyme phosphatidylinositol 3‐kinase (PI3K) was recently implicated in the mediation of arterial spontaneous tone, an event observed in…”
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The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions by Hayflick, J S, Kilgannon, P, Gallatin, W M

“…Macromolecular adhesive associations between cells are important for transmitting spatial and temporal information that is critical for immune system function…”
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Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor- β by Seeburg, Peter H, Ying, Shao-Yao, Hayflick, Joel S, Ueno, Naoto, Mason, Anthony J, Esch, Frederick, Guillemin, Roger, Ling, Nicholas, Niall, Hugh

“…Inhibin, a specific and potent polypeptide inhibitor of the secretion of follicle-stimulating hormone (FSH), of gonadal origin and thus a potential…”
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A Deletion Truncating the Gonadotropin-Releasing Hormone Gene is Responsible for Hypogonadism in the hpg Mouse by Mason, Anthony J., Hayflick, Joel S., Zoeller, R. Thomas, Young, W. Scott, Phillips, Heidi S., Nikolics, Karoly, Seeburg, Peter H.

“…Hereditary hypogonadism in the hypogonadal (hpg) mouse is caused by a deletional mutation of at least 33.5 kilobases encompassing the distal half of the gene…”
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Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin by Pennica, Diane, Nedwin, Glenn E, Hayflick, Joel S, Seeburg, Peter H, Derynck, Rik, Palladino, Michael A, Kohr, William J, Aggarwal, Bharat B, Goeddel, David V

“…Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties…”
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ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies by Chang, Chewei Anderson, Emberley, Ethan, D'Souza, Aloma L., Zhao, Weilong, Cosgrove, Cormac, Parrish, Karen, Mitra, Diya, Payson, Elmer, Oleksijew, Anatol, Ellis, Paul, Rodriguez, Luis, Duggan, Ryan, Hrusch, Cara, Lasko, Loren, Assaily, Wissam, Zheng, Pingping, Liu, Wei, Hernandez, Axel, McCarthy, Kimberley, Zhang, Zhaomei, Rha, Geunbae, Cao, Zhensheng, Li, Yingchun, Perng, Olivia, Campbell, Jos, Zhang, Gloria, Curran, Tyler, Bruncko, Milan, Marvin, Christopher C., Hobson, Adrian, McPherson, Michael, Uziel, Tamar, Pysz, Marybeth A., Zhao, Xi, Bankovich, Alex, Hayflick, Joel, McDevitt, Michael, Freise, Kevin J., Morgan-Lappe, Susan, Purcell, James W.

“…•ABBV-319 has 3 mechanisms of action that contributed to significant antitumor activity across preclinical models of B-cell malignancy.•ABBV-319 delivers a…”
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Abstract 5672: Pharmacodynamics and potential predictive biomarkers of ABBV-428, a first-in-class mesothelin (MSLN)-CD40 bispecific, in patients with advanced solid tumors by Fang, Hua, Ye, Shiming, Reddy, Anita, Turan, Tolga, Woolley, Andrew, Chao, Debra T., Ramathal, Cyril, Henner, William R., Hew, Kinjal, McDevitt, Michael, Hayflick, Joel, Fan, Frances, Allaire, Kathryn, Fong, Lawrence

“…Abstract Background: ABBV-428 is a first-in-class bispecific antibody against CD40 and MSLN designed to stimulate CD40 for tumor-specific immune activation…”
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Insulin-like growth factor II precursor gene organization in relation to insulin gene family by Dull, Thomas J, Gray, Alane, Hayflick, Joel S, Ullrich, Axel

“…The insulin gene family, comprised of insulin, relaxin, insulin-like growth factors I and II (IGF-I and IGF-II) and possibly the beta-subunit of 7S nerve…”
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The role of endothelial PI3Kγ activity in neutrophil trafficking by Puri, Kamal D., Doggett, Teresa A., Huang, Ching-Yu, Douangpanya, Jason, Hayflick, Joel S., Turner, Martin, Penninger, Josef, Diacovo, Thomas G.

“…Phosphoinositide 3-kinase gamma (PI3Kγ) in neutrophils plays a critical role in the directed migration of these cells into inflamed tissues. In this study, we…”
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Abstract CT257: First-in-human phase 1 studies of PTPN2/1 inhibitors ABBV-CLS-484 and ABBV-CLS-579 in locally advanced or metastatic tumors by LoRusso, Patricia M., Aller, Emiliano Calvo, Yamamoto, Noboru, Lin, Chia-Chi, Beck, Thaddeus, Sommerhalder, David, Oh, Do-Youn, Powderly, John D., Golan, Talia, Abraham, Linu Sara, Hayflick, Joel S., Uziel, Tamar, Brunsdon, Priya, Munasinghe, Wijith, Paddock, Marcia, Hartman, Cathleen Brdlik, Powell, Jonathan, Medeiros, Bruno, Neagu, Martha R., Carneiro, Benedito A.

“…Abstract Background: Protein tyrosine phosphatase non-receptor type 2 and type 1 (PTPN2/1) antagonists inhibit PTPN2/1-mediated negative regulation of immune…”
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The p110δ Isoform of PI3K Differentially Regulates β1 and β2 Integrin-Mediated Monocyte Adhesion and Spreading and Modulates Diapedesis by Ferreira, Alexander M., Isaacs, Harold, Hayflick, Joel S., Rogers, Kem A., Sandig, Martin

“…Objective: Leukocyte diapedesis is misregulated in inflammatory disease and depends on the binding of monocytic LFA-1 and VLA-4 to endothelial ICAM-1 and…”
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