Search Results - "Hayes, Vincent M."

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis by Zhou, Junsong, Wu, Yi, Wang, Lu, Rauova, Lubica, Hayes, Vincent M, Poncz, Mortimer, Essex, David W

“…Protein disulfide isomerase (PDI) has two distinct CGHC redox-active sites; however, the contribution of these sites during different physiologic reactions,…”
Get full text

The disulfide isomerase ERp72 supports arterial thrombosis in mice by Zhou, Junsong, Wu, Yi, Chen, Fengwu, Wang, Lu, Rauova, Lubica, Hayes, Vincent M., Poncz, Mortimer, Li, Hong, Liu, Tong, Liu, Junling, Essex, David W.

“…Several CGHC motif–containing disulfide isomerases support thrombosis. We here report that endoplasmic reticulum protein 72 (ERp72), with 3 CGHC redox-active…”
Get full text

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia by Rauova, Lubica, Hirsch, Jessica D., Greene, Teshell K., Zhai, Li, Hayes, Vincent M., Kowalska, M. Anna, Cines, Douglas B., Poncz, Mortimer

“…Heparin-induced thrombocytopenia (HIT) is a life- and limb-threatening thrombotic disorder that develops after exposure to heparin, often in the setting of…”
Get full text

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model by Ostertag, Eric M., Bdeir, Khalil, Kacir, Stephen, Thiboutot, Michelle, Gulendran, Gayathri, Yunk, Lenka, Hayes, Vincent M., Motto, David G., Poncz, Mortimer, Zheng, X. Long, Cines, Douglas B., Siegel, Don L.

“…BACKGROUND Acquired thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease in which ultralarge von Willebrand factor (UL‐VWF) multimers…”
Get full text

A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT) by Johnston, Ian, Hayes, Vincent M, Cines, Douglas B., Poncz, Mortimer

“…Replicating the complexities of the human blood vessel include the establishment of a 3-D confluency of viable endothelial cells (ECs) on an appropriate…”
Get full text

Enhancing Functional Platelet Release In Vivo from in Vitro-Grown Megakaryocytes Using the Protein Kinase Inhibitor SU6656 by Jarocha, Danuta Jadwiga, Vo, Karen K, Lyde, Randolph B, Hayes, Vincent M, Poncz, Mortimer

“…The clinical demand for platelet transfusions is increasing, threatening the ability to obtain sufficient healthy donors to provide these platelets. Advances…”
Get full text

Platelet Release from Infused CD34+-Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor by Johnston, Ian, Hayes, Vincent M, Dai, Jing, Jarocha, Danuta Jadwiga, Kubes, Paul, Poncz, Mortimer, Rauova, Lubica

“…The release of biologically intact platelets from in vitro-grown megakaryocytes remains one of the challenges in an attempt to replace donor-derived platelets…”
Get full text

The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis by Zhou, Junsong, Wu, Yi, Wang, Lu, Rauova, Lubica, Hayes, Vincent M, Poncz, Mortimer, Essex, David W

“…Protein disulfide isomerase (PDI) catalyzes thiol-disulfide exchange reactions that are critical for protein function. PDI has two distinct CGHC redox-active…”
Get full text

Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia by Andrianova, Izabella, Hayes, Vincent M, Madeeva, Daria, Litvinov, Rustem I., Cines, Douglas B., Poncz, Mortimer, Weisel, John W., Rauova, Lubica

“…Heparin induced thrombocytopenia (HIT) is an iatrogenic antibody-mediated disorder with a paradoxically high propensity for thrombosis. We have shown…”
Get full text

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis by Zhou, Junsong, Wu, Yi, Wang, Lu, Rauova, Lubica, Hayes, Vincent M, Poncz, Mortimer, Essex, David W

“…Protein disulfide isomerase (PDI) has two distinct CGHC redox-active sites; however, the contribution of these sites during different physiologic reactions,…”
Get full text

The disulfide isomerase ERp57 is required for fibrin deposition in vivo by Zhou, J., Wu, Y., Wang, L., Rauova, L., Hayes, V. M., Poncz, M., Essex, D. W.

“…Summary Background ERp57 is required for platelet function; however, whether ERp57 contributes to fibrin generation is unknown. Methods and Results Using an…”
Get full text

Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT) by Rauova, Lubica, Madeeva, Daria, Tutwiler, Valerie, Bailey, Shahara, Hayes, Vincent M., Cines, Douglas B., Poncz, Mortimer

“…HIT is an antibody-mediated disorder characterized by thrombocytopenia and thrombosis. Activation of platelet via FcγRIIA by HIT antibodies complexed to…”
Get full text

Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice by Wang, Yuhuan, Hayes, Vincent M., Paluru, Prasuna, Chou, Stella T., French, Deborah L., Poncz, Mortimer

“…Thrombopoiesis is the process by which megakaryocytes (Megs) release platelets (Plts), but issues remain as to the detailed in vivo mechanisms underlying this…”
Get full text

“Rolling Recruitment” of Endothelial Cell (EC) Activation in the Prothrombotic Nature of Heparin-Induced Thrombocytopenia (HIT) by Hayes, Vincent M, Cines, Douglas B., Poncz, Mortimer, Rauova, Lubica

“…Abstract 536 HIT is an iatrogenic, prothrombotic, immune-mediated disorder associated with antibodies directed against platelet factor 4 (PF4) and heparin…”
Get full text

Imaging Morphologic Changes On Platelet and Monocyte Surfaces In Heparin-Induced Thrombocytopenia (HIT) by Rauova, Lubica, Zhang, Yanjun, Hayes, Vincent M., Nagaswami, Chandrasekaran, Cines, Douglas B., Dong, Jing-fei, Poncz, Mortimer, Weisel, John W.

“…HIT is an iatrogenic complication of heparin therapy caused by antibodies that recognize the platelet chemokine, platelet factor 4 (PF4), complexed to heparin…”
Get full text

The Two Phases of Heparin-Induced Thrombocytopenia (HIT): Early Monocyte/Tissue Factor (TF) Phase and Late Platelet Phase by Rauova, Lubica, Tutwiler, Valerie, Ahn, Hyun Sook, Hayes, Vincent M., Aster, Richard H., Cines, Douglas B., Poncz, Mortimer

“…Abstract 270 HIT is an immune thrombocytopenic disorder associated with a high risk of thrombosis. Mechanistic studies have focused on circulating platelet…”
Get full text

Polyhedrocytes: Compressed Polyhedral Erythrocytes In Contracted Blood Clots and Thrombi by Weisel, John W., Lebedeva, Tatiana, Nagaswami, Chandrasekaran, Hayes, Vincent M., Massefski, Walter, Litvinov, Rustem I., Rauova, Lubica, Lowery, Thomas J., Cines, Douglas B.

“…Contraction of blood clots is necessary for hemostasis, wound healing and to restore flow past obstructive thrombi. However, little has been known about the…”
Get full text

FcγRIIa Enhances Thrombus Growth in Vitro and in Vivo by Zhi, Huiying, Rauova, Lubica, Hayes, Vincent M, Crockett, Jimmy, Gao, Cunji, Boylan, Brian, Newman, Debra K., McKenzie, Steven, Cooley, Brian C., Poncz, Mortimer, Newman, Peter J.

“…Abstract 191 Outside-in signal transduction is one of several autocrine amplification loops that platelets employ to stabilize and consolidate a platelet…”
Get full text

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT) by Fuentes, Rudy, Ahn, Hyun Sook, Hayes, Vincent M., Tutwiler, Valerie, Wang, Yuhuan, Bougie, Daniel W., Kowalska, M. Anna, Rauova, Lubica, Aster, Richard H., Cines, Douglas B., Muzykantov, Vladimir R, Poncz, Mortimer, Zaitsev, Sergei

“…Abstract 1171 Thrombolytic therapies are limited in their use to acute life- or limb-threatening thrombosis due to the high risk of significant bleeding. To…”
Get full text

Fibrin Generation in Heparin-Induced Thrombocytopenia (HIT): Pathomechanistic Background for Novel Therapy and Prophylaxis by Tutwiler, Valerie, Ahn, Hyun Sook, Fuentes, Rudy, Hayes, Vincent M., Zaytsev, Sergei V., Zheng, X. Long, Cines, Douglas B., McKenzie, Steven E., Weisel, John W., Poncz, Mortimer, Rauova, Lubica

“…Abstract 635 HIT is an immune mediated prothrombotic disorder often associated with life- and limb-threatening thrombosis caused by antibodies to a complex…”
Get full text