Search Results - "Hayes, Martin E."

Scalable Synthesis and Isolation of the Four Stereoisomers of Methyl 1-Amino-3-(4-bromophenyl)cyclopentanecarboxylate, Useful Intermediates for the Synthesis of S1P1 Receptor Agonists by Wallace, Grier A, Gordon, Thomas D, Hayes, Martin E, Konopacki, Donald B, Fix-Stenzel, Shannon R, Zhang, Xiaolei, Grongsaard, Pintipa, Cusack, Kevin P, Schaffter, Lisa M, Henry, Rodger F, Stoffel, Robert H

“…The individual isomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate are useful intermediates for the synthesis of S1P1 receptor agonists. Herein…”
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Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads by Hobson, Adrian D, McPherson, Michael J, Waegell, Wendy, Goess, Christian A, Stoffel, Robert H, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H, Mathieu, Suzanne L, Bischoff, Agnieszka K, Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C, Wang, Lu, Wang, Lu, Marvin, Christopher C, Hayes, Martin E, Shrestha, Anurupa, Sarris, Kathy A, Li, Biqin

“…Glucocorticoid receptor modulators (GRM) are the first-line treatment for many immune diseases, but unwanted side effects restrict chronic dosing. However,…”
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Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody–Drug Conjugates by Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael, Dunstan, Theresa A., Vargo, Thomas R., Hayes, Martin E., Fettis, Margaret M., Bischoff, Agnieszka, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Oh, Jason Z., Tian, Yu

“…Antibody–drug conjugates consist of potent small-molecule payloads linked to a targeting antibody. Payloads must possess a viable functional group by which a…”
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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Bischoff, Agnieszka K., Fitzgibbons, Julia, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Goess, Christian A., Bryant, Shaughn H., Mathieu, Suzanne L., Xu, Jianwen

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC)…”
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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate by Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa

“…Using a convergent synthetic route to enable multiple points of diversity, a series of glucocorticoid receptor modulators (GRM) were profiled for potency,…”
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An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases by McPherson, Michael J, Hobson, Adrian D, Hernandez, Jr, Axel, Marvin, Christopher C, Waegell, Wendy, Goess, Christian, Oh, Jason Z, Shi, Dan, Hayes, Martin E, Wang, Lu, Wang, Lu, Schmidt, Diana, Wang, Zhi, Pitney, Victoria, McCarthy, Kimberley, Jia, Ying, Wang, Ce, Kang, Bit Na, Bryant, Shaughn, Mathieu, Suzanne, Ruzek, Melanie, Parmentier, Julie, D'Cunha, Ronilda R, Pang, Yinuo, Phillips, Lucy, Brown, Nathan J, Xu, Jianwen, Graff, Candace, Tian, Yu, Longenecker, Kenton L, Qiu, Wei, Zhu, Haizhong, Liu, Wei, Zheng, Pingping, Bi, Yingtao, Stoffel, Robert

“…Glucocorticoids (GCs) are efficacious drugs used for treating many inflammatory diseases, but the dose and duration of administration are limited because of…”
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Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads” by Hobson, Adrian D., McPherson, Michael J., Waegell, Wendy, Goess, Christian A., Stoffel, Robert H., Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C., Wang, Lu, Wang, Lu, Marvin, Christopher C., Hayes, Martin E., Shrestha, Anurupa, Sarris, Kathy A., Li, Biqin

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Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate” by Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa

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Intramolecular [4 + 2] Cycloadditions of Benzynes with Conjugated Enynes, Arenynes, and Dienes by Hayes, Martin E, Shinokubo, Hiroshi, Danheiser, Rick L

“…Benzynes generated by the reaction of o-(trimethylsilyl)aryl triflates with TBAT participate in intramolecular [4 + 2] cycloadditions with conjugated enynes,…”
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Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3 by Hayes, Martin E., Wallace, Grier A., Grongsaard, Pintipa, Bischoff, Agnieszka, George, Dawn M., Miao, Wenyan, McPherson, Michael J., Stoffel, Robert H., Green, David W., Roth, Gregory P.

“…High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay…”
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A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist by Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.

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Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3 by Hayes, Martin E., Breinlinger, Eric C., Wallace, Grier A., Grongsaard, Pintipa, Miao, Wenyan, McPherson, Michael J., Stoffel, Robert H., Green, David W., Roth, Gregory P.

“…Modification of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an…”
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A stereoselective and scalable synthesis of a conformationally constrained S1P 1 agonist by Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.

“…A scalable and enantioselective synthesis of a potent S1P 1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the…”
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Biopsy by needle puncture and aspiration by Martin, Hayes E., Ellis, Edward B.

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The Zoologic Distribution of Intra-oral Cancer by Martin, Hayes E., Holland, Beulah F.

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BIOPSY BY NEEDLE PUNCTURE AND ASPIRATION by Martin, H E, Ellis, E B

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Spindle-Cell Epidermoid Carcinoma by Martin, H. E., Stewart, F. W.

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GLOSSITIS RHOMBICA MEDIANA by Martin, H E, Howe, M E

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Treatment of bilateral retinoblastoma by irradiation and surgery; report on 15-year results by REESE, A B, MERRIAM, Jr, G R, MARTIN, H E

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