Search Results - "Hayes, John D."

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism by Hayes, John D., Dinkova-Kostova, Albena T.

“…•Nrf2 is part of a complex regulatory network that responds to environmental cues.•Nrf2 allows adaptation by inducing cytoprotective genes and maintaining…”
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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer by Hayes, John D., McMahon, Michael

“…Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant and…”
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The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic by O'Connell, Maria A, Hayes, John D

“…The transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, with gene called NFE2L2) is a master regulator of the antioxidant response. In…”
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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases by Cuadrado, Antonio, Rojo, Ana I., Wells, Geoffrey, Hayes, John D., Cousin, Sharon P., Rumsey, William L., Attucks, Otis C., Franklin, Stephen, Levonen, Anna-Liisa, Kensler, Thomas W., Dinkova-Kostova, Albena T.

“…The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2 ) and its principal negative regulator, the E3 ligase adaptor Kelch-like…”
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Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3 by Hayes, John D, Chowdhry, Sudhir, Dinkova-Kostova, Albena T, Sutherland, Calum

“…Nuclear factor-erythroid 2 p45 (NF-E2 p45)-related factor 2 (Nrf2) is a master regulator of redox homoeostasis that allows cells to adapt to oxidative stress…”
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SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner by Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription by Jain, Ashish, Lamark, Trond, Sjøttem, Eva, Bowitz Larsen, Kenneth, Atesoh Awuh, Jane, Øvervatn, Aud, McMahon, Michael, Hayes, John D., Johansen, Terje

“…The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated targets, is up-regulated by various…”
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Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway by Hayes, John D, McMahon, Michael, Chowdhry, Sudhir, Dinkova-Kostova, Albena T

“…The cap'n'collar (CNC) bZIP transcription factor Nrf2 controls expression of genes for antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes,…”
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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals by McMahon, Michael, Lamont, Douglas J., Beattie, Kenneth A., Hayes, John D., Murphy, Mike P.

“…Recognition and repair of cellular damage is crucial if organisms are to survive harmful environmental conditions. In mammals, the Keap1 protein orchestrates…”
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NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis by Robertson, Holly, Dinkova-Kostova, Albena T, Hayes, John D

“…NF-E2 p45-related factor 2 (NRF2, encoded in the human by ) mediates short-term adaptation to thiol-reactive stressors. In normal cells, activation of NRF2 by…”
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Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents by Higgins, Larry G., Hayes, John D.

“…Glutathione transferase (GST) isoezymes are encoded by three separate families of genes (designated cytosolic, microsomal and mitochondrial transferases), with…”
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Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains by Zhang, Yiguo, Ren, Yonggang, Li, Shaojun, Hayes, John D

“…The membrane-bound Nrf1 transcription factor regulates critical homeostatic and developmental genes. The conserved N-terminal homology box 1 (NHB1) sequence in…”
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Glutathione transferases by HAYES, John D, FLANAGAN, Jack U, JOWSEY, Ian R

“…This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now…”
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Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis by Rada, Patricia, Rojo, Ana I., Evrard-Todeschi, Nathalie, Innamorato, Nadia G., Cotte, Axelle, Jaworski, Tomasz, Tobón-Velasco, Julio C., Devijver, Herman, García-Mayoral, María Flor, Van Leuven, Fred, Hayes, John D., Bertho, Gildas, Cuadrado, Antonio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes by Ohtsuji, Makiko, Katsuoka, Fumiki, Kobayashi, Akira, Aburatani, Hiroyuki, Hayes, John D., Yamamoto, Masayuki

“…Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that commonly contains a unique basic-leucine zipper domain. Among CNC family…”
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cancer chemopreventive actions of phytochemicals derived from glucosinolates by Hayes, John D, Kelleher, Michael O, Eggleston, Ian M

“…This article reviews the mechanisms by which glucosinolate breakdown products are thought to inhibit carcinogenesis. It describes how isothiocyanates,…”
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Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha by Wang, Xiu Jun, Hayes, John D, Henderson, Colin J, Wolf, C. Roland

“…Isothiocyanates and phenolic antioxidants can prevent cancer through activation of Nrf2 (NF-E2 p45-related factor 2), a transcription factor that controls…”
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Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3‑Nitrobenzanthrone in Human Lung Cells by Murray, Jessica R, de la Vega, Laureano, Hayes, John D, Duan, Ling, Penning, Trevor M

“…3-Nitrobenzanthrone (3-NBA) is a suspected human carcinogen present in diesel exhaust. It requires metabolic activation via nitroreduction in order to form DNA…”
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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2) by Sharma, Ritu S, Harrison, David J, Kisielewski, Dorothy, Cassidy, Diane M, McNeilly, Alison D, Gallagher, Jennifer R, Walsh, Shaun V, Honda, Tadashi, McCrimmon, Rory J, Dinkova-Kostova, Albena T, Ashford, Michael L.J, Dillon, John F, Hayes, John D

“…Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related…”
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Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression by McMahon, Michael, Itoh, Ken, Yamamoto, Masayuki, Hayes, John D.

“…Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to oxidative stress. Previous studies suggested this negative…”
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