Search Results - "Hayes, Gregory M"

Antitumor activity of an anti‐CD98 antibody by Hayes, Gregory M., Chinn, Lawrence, Cantor, Joseph M., Cairns, Belinda, Levashova, Zoia, Tran, Hoang, Velilla, Timothy, Duey, Dana, Lippincott, John, Zachwieja, Joseph, Ginsberg, Mark H., H. van der Horst, Edward

“…CD98 is expressed on several tissue types and specifically upregulated on fast‐cycling cells undergoing clonal expansion. Various solid (e.g., nonsmall cell…”
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The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy by Long, Brian R., Sandza, Krystal, Holcomb, Jennifer, Crockett, Lucy, Hayes, Gregory M., Arens, Jeremy, Fonck, Carlos, Tsuruda, Laurie S., Schweighardt, Becky, O’Neill, Charles A., Zoog, Stephen, Vettermann, Christian

“…Adeno-associated virus (AAV)-based vectors are widely used for gene therapy, but the effect of pre-existing antibodies resulting from exposure to wild-type AAV…”
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Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma by HAYES, Gregory M, CARRIGAN, Patricia E, BECK, Alison M, MILLER, Laurence J

“…Aberrant patterns of pre-mRNA splicing have been established for many human malignancies, yet the mechanisms responsible for these tumor-specific changes…”
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Development of an Improved Epstein-Barr Virus (EBV) Neutralizing Antibody Assay to Facilitate Development of a Prophylactic gp350-Subunit EBV Vaccine by Liu, Hui, Gemmell, Lorraine, Lin, Rui, Zuo, Fengrong, Balfour, Jr, Henry H, Woo, Jennifer C, Hayes, Gregory M

“…No licensed vaccine is available for prevention of EBV-associated diseases, and robust, high-throughput bioanalytical assays are needed to evaluate…”
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Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A by Long, Brian R., Veron, Philippe, Kuranda, Klaudia, Hardet, Romain, Mitchell, Nina, Hayes, Gregory M., Wong, Wing Yen, Lau, Kelly, Li, Mingjin, Hock, M. Benjamin, Zoog, Stephen J., Vettermann, Christian, Mingozzi, Federico, Schweighardt, Becky

“…Evaluation of immune responses to adeno-associated virus (AAV)-mediated gene therapies prior to and following dose administration plays a key role in…”
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Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas by HAYES, Gregory M, CARRIGAN, Patricia E, MILLER, Laurence J

“…Aberrant patterns of pre-mRNA processing are typical of human malignancies, yet the mechanisms responsible for these changes remain undefined. We have recently…”
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Measurement of cell proliferation by heavy water labeling by Hellerstein, Marc K, Busch, Robert, Neese, Richard A, Awada, Mohamad, Hayes, Gregory M

“…DNA replication occurs almost exclusively during S-phase of the cell cycle and represents a simple biochemical metric of cell division. Previous methods for…”
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Rapid antibody responses to Epstein-Barr virus correlate with reduced severity of primary infection by Geris, Jennifer M., Stancari, Arianna L., Meirhaeghe, Madeline R., Gautam, Sakhi, Cayatte, Corinne, Schmeling, David O., Okour, Malek F., Brundage, Richard C., Hayes, Gregory M., Balfour, Henry H.

“…•More rapid antibody responses in college freshmen who contracted a primary EBV infection.•during prospective surveillance correlated with a lower severity of…”
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Identification of the critical attribute(s) of EBV gp350 antigen required for elicitation of a neutralizing antibody response in vivo by Servat, Esteban, Ro, Bodrey W, Cayatte, Corinne, Gemmell, Lorraine, Barton, Chris, Rao, Eileen, Lin, Rui, Zuo, Fengrong, Woo, Jennifer C, Hayes, Gregory M

“…Highlights • Identification of critical quality attributes for EBV gp350 vaccine development. • Requirement of 72A1 epitope on recombinant gp350 for binding to…”
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Kinetics of Epstein-Barr Virus (EBV) Neutralizing and Virus-Specific Antibodies after Primary Infection with EBV by Bu, Wei, Hayes, Gregory M, Liu, Hui, Gemmell, Lorraine, Schmeling, David O, Radecki, Pierce, Aguilar, Fiona, Burbelo, Peter D, Woo, Jennifer, Balfour, Jr, Henry H, Cohen, Jeffrey I

“…Prospective studies of antibodies to multiple Epstein-Barr virus (EBV) proteins and EBV neutralizing antibodies in the same individuals before, during, and…”
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CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma by Hayes, Gregory M, Cairns, Belinda, Levashova, Zoia, Chinn, Lawrence, Perez, Myra, Theunissen, Jan-Willem, Liao-Chan, Sindy, Bermudez, Abel, Flory, Mark R, Schweighofer, Karl J, H van der Horst, Edward

“…Soft tissue sarcoma (STS) is a heterogenous tumor arising from the embryonic mesoderm represented by approximately 50 histological subtypes. Effective…”
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Regional Cell Proliferation in Microdissected Human Prostate Specimens after Heavy Water Labeling In Vivo: Correlation with Prostate Epithelial Cells Isolated from Seminal Fluid by HAYES, Gregory M, SIMKO, Jeff, HELLERSTEIN, Marc K, HOLOCHWOST, Daniel, KUCHINSKY, Kyle, BUSCH, Robert, MISELL, Lisa, MURPHY, Elizabeth J, CARROLL, Peter, CHAN, June, SHINOHARA, Katsuto

“…Prostate cancer is detected with increasing frequency but has a highly variable natural history and prognosis and active surveillance of men with low-risk…”
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Identification of Sequence Motifs Responsible for the Adhesive Interaction between Exon v10-containing CD44 Isoforms by Hayes, Gregory M., Chiu, Roland, Carpenito, Carmine, Dougherty, Shona T., Dougherty, Graeme J.

“…Previous studies have demonstrated that CD44 isoforms containing the alternatively spliced exon v10 promote cell-cell adhesion via a mechanism that involves…”
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Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography/pyrolysis/isotope ratio-mass spectrometric analysis by Hellerstein, Marc K, Voogt, Jason N, Awada, Mohamad, Murphy, Elizabeth J, Hayes, Gregory M, Busch, Robert

“…DNA replication during S-phase represents a biochemical metric of cell division. We present here a protocol for measuring very low rates of cell proliferation,…”
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Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma by Körner, Meike, Hayes, Gregory M., Rehmann, Ruth, Zimmermann, Arthur, Scholz, Arne, Wiedenmann, Bertram, Miller, Laurence J., Reubi, Jean Claude

“…Gut hormone receptors are over-expressed in human cancer and allow receptor-targeted tumor imaging and therapy. A novel promising receptor for these purposes…”
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Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: Validation of a simplified method suitable for multi-center clinical studies by Hayes, Gregory M, Busch, Robert, Voogt, Jason, Siah, Iche M, Gee, Tracy A, Hellerstein, Marc K, Chiorazzi, Nicholas, Rai, Kanti R, Murphy, Elizabeth J

“…Abstract Background Heavy water (2 H2 O) labelling of DNA enables the measurement of low-level cell proliferation in vivo, using gas chromatography/pyrolysis…”
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Identification and Characterization of CD44RC, a Novel Alternatively Spliced Soluble CD44 Isoform that can Potentiate the Hyaluronan Binding Activity of Cell Surface CD44 by Chiu, Roland K., Carpenito, Carmine, Dougherty, Shona T., Hayes, Gregory M., Dougherty, Graeme J.

“…Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the…”
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A Novel Secretin Receptor Splice Variant Potentially Useful for Early Diagnosis of Pancreatic Carcinoma by Hayes, Gregory M, Carrigan, Patricia E, Dong, Maoqing, Reubi, Jean–Claude, Miller, Laurence J

“…Background & Aims: Pancreatic and bile duct carcinomas represent highly aggressive malignancies that evolve from secretin receptor-rich ductular cells. With…”
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Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue by Körner, Meike U, Hayes, Gregory M, Carrigan, Patricia E, Rehmann, Ruth, Miller, Laurence J, Reubi, Jean C

“…Gastrointestinal peptide hormone receptors, like somatostatin receptors, are often overexpressed in human cancer, allowing receptor-targeted tumor imaging and…”
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Secretin Receptors in Normal and Diseased Human Pancreas: Marked Reduction of Receptor Binding in Ductal Neoplasia by Korner, Meike, Hayes, Gregory M, Rehmann, Ruth, Zimmermann, Arthur, Friess, Helmut, Miller, Laurence J, Reubi, Jean Claude

“…Receptors for gut hormones, which are often overexpressed in cancer, are clinically relevant for receptor-targeted tumor imaging and therapy. Because the…”
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