Search Results - "Hayes, Ben"
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Overview of Statistical Methods for Genome-Wide Association Studies (GWAS)
Published in Methods in molecular biology (Clifton, N.J.) (2013)“…This chapter provides an overview of statistical methods for genome-wide association studies (GWAS) in animals, plants, and humans. The simplest form of GWAS,…”
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Harnessing genomic information for livestock improvement
Published in Nature reviews. Genetics (01-03-2019)“…The world demand for animal-based food products is anticipated to increase by 70% by 2050. Meeting this demand in a way that has a minimal impact on the…”
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Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model
Published in PLoS genetics (01-04-2015)“…Gene discovery, estimation of heritability captured by SNP arrays, inference on genetic architecture and prediction analyses of complex traits are usually…”
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1000 Bull Genomes Project to Map Simple and Complex Genetic Traits in Cattle: Applications and Outcomes
Published in Annual review of animal biosciences (15-02-2019)“…The 1000 Bull Genomes Project is a collection of whole-genome sequences from 2,703 individuals capturing a significant proportion of the world's cattle…”
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A multi-trait, meta-analysis for detecting pleiotropic polymorphisms for stature, fatness and reproduction in beef cattle
Published in PLoS genetics (01-03-2014)“…Polymorphisms that affect complex traits or quantitative trait loci (QTL) often affect multiple traits. We describe two novel methods (1) for finding single…”
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Metric mean dimension for algebraic actions of Sofic groups
Published in Transactions of the American Mathematical Society (01-10-2017)“…We prove that if \Gamma is a sofic group and A is a finitely generated \mathbb{Z}(\Gamma )-module, then the metric mean dimension of \Gamma \curvearrowright…”
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Mapping genes for complex traits in domestic animals and their use in breeding programmes
Published in Nature reviews. Genetics (01-06-2009)“…The availability of genome-wide panels of SNPs for many domestic animals has allowed the mapping and identification of many economically important traits in…”
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The future of livestock breeding: genomic selection for efficiency, reduced emissions intensity, and adaptation
Published in Trends in genetics (01-04-2013)“…As the global population and global wealth both continue to increase, so will the demand for livestock products, especially those that are highly nutritious…”
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Breeding crops to feed 10 billion
Published in Nature biotechnology (01-07-2019)“…Crop improvements can help us to meet the challenge of feeding a population of 10 billion, but can we breed better varieties fast enough? Technologies such as…”
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A chickpea genetic variation map based on the sequencing of 3,366 genomes
Published in Nature (London) (25-11-2021)“…Zero hunger and good health could be realized by 2030 through effective conservation, characterization and utilization of germplasm resources 1 . So far, few…”
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Pitfalls of predicting complex traits from SNPs
Published in Nature reviews. Genetics (01-07-2013)“…The data from genome-wide association studies can be applied to genotype data to predict the phenotype of a complex trait. Here the authors discuss the…”
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Accuracy of genomic breeding values in multi-breed dairy cattle populations
Published in Genetics selection evolution (Paris) (24-11-2009)“…Two key findings from genomic selection experiments are 1) the reference population used must be very large to subsequently predict accurate genomic estimated…”
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Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traits
Published in PLoS genetics (01-09-2010)“…Prediction of genetic merit using dense SNP genotypes can be used for estimation of breeding values for selection of livestock, crops, and forage species; for…”
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Multibreed genome wide association can improve precision of mapping causative variants underlying milk production in dairy cattle
Published in BMC genomics (24-01-2014)“…Genome wide association studies (GWAS) in most cattle breeds result in large genomic intervals of significant associations making it difficult to identify…”
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A dense SNP-based linkage map for Atlantic salmon (Salmo salar) reveals extended chromosome homeologies and striking differences in sex-specific recombination patterns
Published in BMC genomics (19-12-2011)“…The Atlantic salmon genome is in the process of returning to a diploid state after undergoing a whole genome duplication (WGD) event between 25 and100 million…”
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A catalogue of novel bovine long noncoding RNA across 18 tissues
Published in PloS one (23-10-2015)“…Long non-coding RNA (lncRNA) have been implicated in diverse biological roles including gene regulation and genomic imprinting. Identifying lncRNA in bovine…”
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Genomic prediction using low-coverage portable Nanopore sequencing
Published in PloS one (15-12-2021)“…Most traits in livestock, crops and humans are polygenic, that is, a large number of loci contribute to genetic variation. Effects at these loci lie along a…”
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Genetic variation in PLAG1 is associated with early fertility in Australian Brahman cattle
Published in Journal of animal science (01-04-2022)“…Abstract Variation in the genome region coding for PLAG1 has well-documented associations with skeletal growth and age at puberty in cattle. However, the…”
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Metagenomic predictions: from microbiome to complex health and environmental phenotypes in humans and cattle
Published in PloS one (04-09-2013)“…Mammals have a large cohort of endo- and ecto- symbiotic microorganisms (the microbiome) that potentially influence host phenotypes. There have been numerous…”
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Exome sequencing highlights the role of wild-relative introgression in shaping the adaptive landscape of the wheat genome
Published in Nature genetics (01-05-2019)“…Introgression is a potential source of beneficial genetic diversity. The contribution of introgression to adaptive evolution and improvement of wheat as it was…”
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