Search Results - "Hayenga, Heather N"

An agent-based model of leukocyte transendothelial migration during atherogenesis by Bhui, Rita, Hayenga, Heather N

“…A vast amount of work has been dedicated to the effects of hemodynamics and cytokines on leukocyte adhesion and trans-endothelial migration (TEM) and…”
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Shape-Morphing Chromonic Liquid Crystal Hydrogels by Kularatne, Ruvini S, Kim, Hyun, Ammanamanchi, Manasvini, Hayenga, Heather N, Ware, Taylor H

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Human neutrophil cytoskeletal dynamics and contractility actively contribute to trans-endothelial migration by Stroka, Kimberly M, Hayenga, Heather N, Aranda-Espinoza, Helim

“…Transmigration through the endothelium is a key step in the immune response. In our recent work, the mechanical properties of the subendothelial matrix and…”
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Analysis of Plaque Characteristics by Virtual Histology-Intravascular Ultrasound in Short-Term Follow-Up Post-Acute Coronary Syndrome and Association With Lipid-Lowering Therapy: Insights From the PREMIER Trial by Kole, Ayeeshik, Hua, Feng, Wei, Yongliang, Carlson, Kimberly, Hayenga, Heather N, Banerjee, Subhash

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Assessment with clinical data of a coupled bio-hemodynamics numerical model to predict leukocyte adhesion in coronary arteries by Ciri, Umberto, Bennett, Ruth L., Bhui, Rita, Molony, David S., Samady, Habib, Meyer, Clark A., Hayenga, Heather N., Leonardi, Stefano

“…Numerical simulations of coupled hemodynamics and leukocyte transport and adhesion inside coronary arteries have been performed. Realistic artery geometries…”
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STAT6-targeting antisense oligonucleotides against solitary fibrous tumor by Li, Yi, Mondaza-Hernandez, Jose L., Moura, David S., Revenko, Alexey S., Tolentino, Angelica, Nguyen, John T., Tran, Nam, Meyer, Clark A., Merino-Garcia, Jose, Ramos, Rafael, Di Lernia, Davide, Martin-Broto, Javier, Hayenga, Heather N., Bleris, Leonidas

“…Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT…”
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Automated finite element approach to generate anatomical patient-specific biomechanical models of atherosclerotic arteries from virtual histology-intravascular ultrasound by Warren, Jeremy L, Yoo, John E, Meyer, Clark A, Molony, David S, Samady, Habib, Hayenga, Heather N

“…Despite advancements in early detection and treatment, atherosclerosis remains the leading cause of death across all cardiovascular diseases (CVD)…”
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Ensuring Congruency in Multiscale Modeling: Towards Linking Agent Based and Continuum Biomechanical Models of Arterial Adaptation by Hayenga, Heather N., Thorne, Bryan C., Peirce, Shayn M., Humphrey, Jay D.

“…There is a need to develop multiscale models of vascular adaptations to understand tissue-level manifestations of cellular level mechanisms. Continuum-based…”
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PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity by Nemir, Stephanie, Hayenga, Heather N, West, Jennifer L

“…The ability of cells to migrate in response to mechanical gradients (durotaxis) and differential cell behavior in adhesion, spreading, and proliferation in…”
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Osteogenic potential of poly(ethylene glycol)-poly(dimethylsiloxane) hybrid hydrogels by Munoz-Pinto, Dany J, Jimenez-Vergara, Andrea Carolina, Hou, Yaping, Hayenga, Heather N, Rivas, Alejandra, Grunlan, Melissa, Hahn, Mariah S

“…Growth factors have been shown to be potent mediators of osteogenesis. However, their use in tissue-engineered scaffolds not only can be costly but also can…”
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Substrate elasticity regulates the behavior of human monocyte-derived macrophages by Adlerz, Katrina M., Aranda-Espinoza, Helim, Hayenga, Heather N.

“…Macrophages play a key role in atherosclerosis, cancer, and in the response to implanted medical devices. In each of these situations, the mechanical…”
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Inflammation Drives Stiffness Mediated Uptake of Lipoproteins in Primary Human Macrophages and Foam Cell Proliferation by Ammanamanchi, Manasvini, Maurer, Melanie, Hayenga, Heather N.

“…Macrophage to foam cell transition and their accumulation in the arterial intima are the key events that trigger atherosclerosis, a multifactorial inflammatory…”
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Reversibly Modulating the Blood–Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles by Li, Xiaoqing, Vemireddy, Vamsidhara, Cai, Qi, Xiong, Hejian, Kang, Peiyuan, Li, Xiuying, Giannotta, Monica, Hayenga, Heather N, Pan, Edward, Sirsi, Shashank R, Mateo, Celine, Kleinfeld, David, Greene, Chris, Campbell, Matthew, Dejana, Elisabetta, Bachoo, Robert, Qin, Zhenpeng

“…The blood–brain barrier (BBB) is highly selective and acts as the interface between the central nervous system and circulation. While the BBB is critical for…”
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Targeting Hypoxia-Inducible Factor-1a/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis by Goodwin, Justin, Choi, Hyunsung, Hsieh, Meng-hsiung, Neugent, Michael L, Ahn, Jung-Mo, Hayenga, Heather N, Singh, Pankaj K, Shackelford, David B, Lee, In-Kyu, Shulaev, Vladimir, Dhar, Shanta, Takeda, Norihiko, Kim, Jung-whan

“…Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are the primary pathological driver of fibrotic…”
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Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis by Goodwin, Justin, Choi, Hyunsung, Hsieh, Meng-Hsiung, Neugent, Michael L, Ahn, Jung-Mo, Hayenga, Heather N, Singh, Pankaj K, Shackelford, David B, Lee, In-Kyu, Shulaev, Vladimir, Dhar, Shanta, Takeda, Norihiko, Kim, Jung-Whan

“…Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are the primary pathological driver of fibrotic…”
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Clinical gene therapy development for the central nervous system: Candidates and challenges for AAVs by Leong, Tiffany W., Pal, Arindam, Cai, Qi, Gao, Zhenghong, Li, Xiaoqing, Bleris, Leonidas, Hayenga, Heather N., Qin, Zhenpeng

“…Many diseases affecting the central nervous system (CNS) are deadly but less understood, leading to impaired mental and motor capabilities and poor patient…”
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Mechanobiological model of arterial growth and remodeling by Keshavarzian, Maziyar, Meyer, Clark A., Hayenga, Heather N.

“…A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors…”
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Intraspinal Dissemination and Local Recurrence of an Intracranial Hemangiopericytoma by Hayenga, Heather N., Bishop, Andrew J., Wardak, Zabi, Sen, Chandra, Mickey, Bruce

“…Hemangiopericytomas (HPCs) are rare vascular tumors that resemble meningiomas on imaging and have a high rate of local recurrence and metastases. There remains…”
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Dependence of leukocyte capture on instantaneous pulsatile flow by Ciri, Umberto, Bhui, Rita, Bailon-Cuba, Jorge, Hayenga, Heather N., Leonardi, Stefano

“…Atherosclerosis, an artery disease, is currently the leading cause of death in the United States in both men and women. The first step in the development of…”
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p66Shc Couples Mechanical Signals to RhoA through Focal Adhesion Kinase-Dependent Recruitment of p115-RhoGEF and GEF-H1 by Wu, Ru-Feng, Liao, Chengxu, Fu, Guosheng, Hayenga, Heather N., Yang, Kejia, Ma, Zhenyi, Liu, Zhe, Terada, Lance S.

“…Tissue cells respond to changes in tensional forces with proliferation or death through the control of RhoA. However, the response coupling mechanisms that…”
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