Search Results - "Hayden, Rachel E."

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids by Southam, Andrew D, Khanim, Farhat L, Hayden, Rachel E, Constantinou, Julia K, Koczula, Katarzyna M, Michell, Robert H, Viant, Mark R, Drayson, Mark T, Bunce, Chris M

“…The redeployed drug combination of bezafibrate and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity in acute myelogenous…”
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Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia by Khanim, Farhat L, Hayden, Rachel E, Birtwistle, Jane, Lodi, Alessia, Tiziani, Stefano, Davies, Nicholas J, Ride, Jon P, Viant, Mark R, Gunther, Ulrich L, Mountford, Joanne C, Schrewe, Heinrich, Green, Richard M, Murray, Jim A, Drayson, Mark T, Bunce, Chris M

“…The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also…”
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Nm23-H1 Indirectly Promotes the Survival of Acute Myeloid Leukemia Blast Cells by Binding to More Mature Components of the Leukemic Clone by LILLY, Andrew J, KHANIM, Farhat L, HAYDEN, Rachel E, LUONG, Quang T, DRAYSON, Mark T, BUNCE, Christopher M

“…Nm23-H1 plays complex roles in the development of diverse cancers including breast carcinoma, high-grade lymphomas, and acute myeloid leukemia (AML). In the…”
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Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance by HAYDEN, Rachel E, PRATT, Guy, DRAYSON, Mark T, BUNCE, Chris M

“…Tumor cells in chronic lymphocytic leukemia accumulate in the periphery through the proliferation of a minority of cells in lymph nodes. The proliferative and…”
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Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells by Mirbahai, Leda, Kershaw, Rachael M., Green, Richard M., Hayden, Rachel E., Meldrum, Rosalind A., Hodges, Nikolas J.

“…An abundant form of DNA damage caused by reactive oxygen species is 8-oxo-7,8-dihydroguanine for which the base excision repair protein 8-oxoguanine-DNA…”
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AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects by DAVIES, Nicholas J, HAYDEN, Rachel E, SIMPSON, Paul J, BIRTWISTLE, Jane, MAYER, Katarina, RIDE, Jonathan P, BUNCE, Chris M

“…Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of the pathology of cancer. Agents…”
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Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches by Hayden, Rachel E., Pratt, Guy, Roberts, Claudia, Drayson, Mark T., Bunce, Chris M.

“…Abstract Chronic lymphocytic leukemia (CLL) remains associated with low complete response rates and high relapse rates. This is in part due to poor…”
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Bezafibrate and medroxyprogesterone acetate target resting and CD40L-stimulated primary marginal zone lymphoma and show promise in indolent B-cell non-Hodgkin lymphomas by Hayden, Rachel E., Kussaibati, Racha, Cronin, Laura M., Pratt, Guy, Roberts, Claudia, Drayson, Mark T., Bunce, Christopher M.

“…Abstract B cell non-Hodgkin lymphomas (B-NHLs) are the most common adult hematological cancers and many remain incurable. Development of chemotherapy regimens…”
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Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML) by Murray, Jim A., Khanim, Farhat L., Hayden, Rachel E., Craddock, Charlie F., Holyoake, Tessa L., Jackson, Nick, Lumley, Matthew, Bunce, Chris M., Drayson, Mark T.

“…Summary Acute myeloid leukaemia (AML) causes life‐threatening deficits of functional blood cells that require management using red cell and platelet…”
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The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs by DESMOND, Julian C, MOUNTFORD, Joanne C, DRAYSON, Mark T, WALKER, Elizabeth A, HEWISON, Martin, RIDE, Jonathan P, LUONG, Quang T, HAYDEN, Rachel E, VANIN, Elio F, BUNCE, Christopher M

“…We and others have demonstrated expression of the aldo-keto reductase AKR1C3 in myeloid leukemia cell lines and that inhibitors of the enzyme, including…”
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Elevated FOSB‐expression; a potential marker of valproate sensitivity in AML by Khanim, Farhat L., Bradbury, Charlotte A., Arrazi, Julie, Hayden, Rachel E., Rye, Adam, Basu, Supratik, MacWhannell, Alan, Sawers, Alistair, Griffiths, Michael, Cook, Mark, Freeman, Sylvie, Nightingale, Karl P., Grimwade, David, Falciani, Francesco, Turner, Bryan M., Bunce, Chris M., Craddock, Charles

“…Summary Histone deacetylase inhibitors (HDIs) are emerging as valuable new agents in the treatment of acute myeloid leukaemia (AML). However, since response…”
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Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy by Pearce, Claire, Hayden, Rachel E, Bunce, Christopher M, Khanim, Farhat L

“…The COP9/signalosome (CSN) is a highly conserved eight subunit complex that, by deneddylating cullins in cullin-based E3 ubiquitin ligases, regulates protein…”
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The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis by Birtwistle, Jane, Hayden, Rachel E, Khanim, Farhat L, Green, Richard M, Pearce, Claire, Davies, Nicholas J, Wake, Naomi, Schrewe, Heiner, Ride, Jonathan P, Chipman, James K, Bunce, Chris M

“…The aldo-keto reductase AKR1C3, has been shown to regulate myelopoiesis via its ability to metabolise prostaglandin D2 (PGD2). Other studies have demonstrated…”
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All-trans retinoic acid increases transgene expression in MSCV-transduced cells, via a mechanism that is retinoid receptor dependent but independent of cellular differentiation by Mountford, Joanne C, Vanin, Elio F, Hayden, Rachel E, Bunce, Christopher M

“…Treatment of MSCV-GFP-transduced HL60 promyelocytic cells with all-trans retinoic acid (ATRA) resulted in a significant increase in GFP expression. The…”
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Supramolecular Iron Cylinder with Unprecedented DNA Binding Is a Potent Cytostatic and Apoptotic Agent without Exhibiting Genotoxicity by Hotze, Anna C.G., Hodges, Nikolas J., Hayden, Rachel E., Sanchez-Cano, Carlos, Paines, Christopher, Male, Natalia, Tse, Man-Kit, Bunce, Chris M., Chipman, J. Kevin, Hannon, Michael J.

“…The supramolecular iron cylinder, [Fe 2L 3]Cl 4 (L = C 25H 20N 4), shows unprecedented DNA binding in vitro, inducing intramolecular DNA coiling and also…”
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Characterisation of Histone Deacetylase (HDAC) Expression Profiles in Acute Myeloid Leukaemia: A Basis for the Development of Targeted Therapy Using Histone Deacetylase Inhibitors by Bradbury, Charlotte A., Khanim, Farhat L., Mehta, Priyanka, Hayden, Rachel E., Craddock, Charles F., Bunce, Chris M., Turner, Bryan M.

“…Post-translational modifications of chromatin structure are recognised as having a potential role in the pathogenesis of acute myeloid leukaemia (AML). Histone…”
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