Search Results - "Hayden, Michael R"

The GALAH+ survey: Third data release by Buder, Sven, Sharma, Sanjib, Kos, Janez, Amarsi, Anish M, Nordlander, Thomas, Lind, Karin, Martell, Sarah L, Asplund, Martin, Bland-Hawthorn, Joss, Casey, Andrew R, De Silva, Gayandhi M, D’Orazi, Valentina, Freeman, Ken C, Hayden, Michael R, Lewis, Geraint F, Lin, Jane, Schlesinger, Katharine J, Simpson, Jeffrey D, Stello, Dennis, Zucker, Daniel B, Zwitter, Tomaž, Beeson, Kevin L, Buck, Tobias, Casagrande, Luca, Clark, Jake T, Čotar, Klemen, Da Costa, Gary S, de Grijs, Richard, Feuillet, Diane, Horner, Jonathan, Kafle, Prajwal R, Khanna, Shourya, Kobayashi, Chiaki, Liu, Fan, Montet, Benjamin T, Nandakumar, Govind, Nataf, David M, Ness, Melissa K, Spina, Lorenzo, Tepper-García, Thor, Ting(丁源森), Yuan-Sen, Traven, Gregor, Vogrinčič, Rok, Wittenmyer, Robert A, Wyse, Rosemary F G, Žerjal, Maruša

“…ABSTRACT The ensemble of chemical element abundance measurements for stars, along with precision distances and orbit properties, provides high-dimensional data…”
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BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice by Xie, Yuxiang, Hayden, Michael R, Xu, Baoji

“…Huntington's disease (HD) is caused by an expansion of the polyglutamine tract at the N terminus of huntingtin. This mutation reduces levels of BDNF in the…”
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Autophagy in Huntington disease and huntingtin in autophagy by Martin, Dale D.O, Ladha, Safia, Ehrnhoefer, Dagmar E, Hayden, Michael R

“…Highlights • HTT is an important regulator of autophagy that is, in turn, degraded by autophagy. • Genes regulating protein clearance show altered expression…”
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Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases by Zhemkov, Vladimir, Geva, Michal, Hayden, Michael R, Bezprozvanny, Ilya

“…The sigma-1 receptor (S1R) is a 223 amino acid-long transmembrane endoplasmic reticulum (ER) protein. The S1R modulates the activity of multiple effector…”
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More codeine fatalities after tonsillectomy in North American children by Kelly, Lauren E, Rieder, Michael, van den Anker, John, Malkin, Becky, Ross, Colin, Neely, Michael N, Carleton, Bruce, Hayden, Michael R, Madadi, Parvaz, Koren, Gideon

“…In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea syndrome. The child was an…”
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Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor by Eddings, Chelsy R., Arbez, Nicolas, Akimov, Sergey, Geva, Michal, Hayden, Michael R., Ross, Christopher A.

“…Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein…”
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The GALAH survey: effective temperature calibration from the InfraRed Flux Method in the Gaia system by Casagrande, Luca, Lin, Jane, Rains, Adam D, Liu, Fan, Buder, Sven, Horner, Jonathan, Asplund, Martin, Lewis, Geraint F, Martell, Sarah L, Nordlander, Thomas, Stello, Dennis, Ting, Yuan-Sen, Wittenmyer, Robert A, Bland-Hawthorn, Joss, Casey, Andrew R, De Silva, Gayandhi M, D’Orazi, Valentina, Freeman, Ken C, Hayden, Michael R, Kos, Janez, Lind, Karin, Schlesinger, Katharine J, Sharma, Sanjib, Simpson, Jeffrey D, Zucker, Daniel B, Zwitter, Tomaž

“…ABSTRACT In order to accurately determine stellar properties, knowledge of the effective temperature of stars is vital. We implement Gaia and 2MASS photometry…”
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Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity by Petrilli, Alejandra, Bossy-Wetzel, Ella, Song, Wenjun, Ellisman, Mark, Rouiller, Isabelle, Klinglmayr, Eva, Chen, Jin, Zhou, Yue, Poquiz, Patrick, Masliah, Eliezer, Tjong, Jonathan, Perkins, Guy, Liot, Geraldine, Hayden, Michael R, Pouladi, Mahmoud A, Schwarzenbacher, Robert, Bossy, Blaise

“…Huntington's disease is an inherited and incurable neurodegenerative disorder caused by an abnormal polyglutamine (polyQ) expansion in huntingtin (encoded by…”
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Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies by Wright, Galen E B, Black, Hailey Findlay, Collins, Jennifer A, Gall-Duncan, Terence, Caron, Nicholas S, Pearson, Christopher E, Hayden, Michael R

“…Huntington's disease is a fatal neurodegenerative disorder that is caused by CAG-CAA repeat expansion, encoding polyglutamine, in the huntingtin (HTT) gene…”
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Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity by Aminkeng, Folefac, Ross, Colin J. D., Rassekh, Shahrad R., Hwang, Soomi, Rieder, Michael J., Bhavsar, Amit P., Smith, Anne, Sanatani, Shubhayan, Gelmon, Karen A., Bernstein, Daniel, Hayden, Michael R., Amstutz, Ursula, Carleton, Bruce C.

“…Aims Anthracycline‐induced cardiotoxicity (ACT) occurs in 57% of treated patients and remains an important limitation of anthracycline‐based chemotherapy. In…”
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Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers by Sanders, Shaun S, Martin, Dale D O, Butland, Stefanie L, Lavallée-Adam, Mathieu, Calzolari, Diego, Kay, Chris, Yates, 3rd, John R, Hayden, Michael R

“…Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent…”
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Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes by Maillet, Agnes, Tan, Kim, Chai, Xiaoran, Sadananda, Singh N., Mehta, Ashish, Ooi, Jolene, Hayden, Michael R., Pouladi, Mahmoud A., Ghosh, Sujoy, Shim, Winston, Brunham, Liam R.

“…Doxorubicin is a highly efficacious anti-cancer drug but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity (DIC)…”
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Fundamental relations for the velocity dispersion of stars in the Milky Way by Sharma, Sanjib, Hayden, Michael R, Bland-Hawthorn, Joss, Stello, Dennis, Buder, Sven, Zinn, Joel C, Kallinger, Thomas, Asplund, Martin, De Silva, Gayandhi M, D’Orazi, Valentina, Freeman, Ken, Kos, Janez, Lewis, Geraint F, Lin, Jane, Lind, Karin, Martell, Sarah, Simpson, Jeffrey D, Wittenmyer, Rob A, Zucker, Daniel B, Zwitter, Tomaz, Chen, Boquan, Cotar, Klemen, Esdaile, James, Hon, Marc, Horner, Jonathan, Huber, Daniel, Kafle, Prajwal R, Khanna, Shourya, Ting, Yuan-Sen, Nataf, David M, Nordlander, Thomas, Saadon, Mohd Hafiz Mohd, Tepper-Garcia, Thor, Tinney, C G, Traven, Gregor, Watson, Fred, Wright, Duncan, Wyse, Rosemary F G

“…ABSTRACT We explore the fundamental relations governing the radial and vertical velocity dispersions of stars in the Milky Way, from combined studies of…”
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Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease by Wright, Galen E.B., Collins, Jennifer A., Kay, Chris, McDonald, Cassandra, Dolzhenko, Egor, Xia, Qingwen, Bečanović, Kristina, Drögemöller, Britt I., Semaka, Alicia, Nguyen, Charlotte M., Trost, Brett, Richards, Fiona, Bijlsma, Emilia K., Squitieri, Ferdinando, Ross, Colin J.D., Scherer, Stephen W., Eberle, Michael A., Yuen, Ryan K.C., Hayden, Michael R.

“…Huntington disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Although the length of this repeat is inversely correlated with age…”
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Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor by Kaye, Joel, Piryatinsky, Victor, Birnberg, Tal, Hingaly, Tal, Raymond, Emanuel, Kashi, Rina, Amit-Romach, Einat, Caballero, Ignacio S., Towfic, Fadi, Ator, Mark A., Rubinstein, Efrat, Laifenfeld, Daphna, Orbach, Aric, Shinar, Doron, Marantz, Yael, Grossman, Iris, Knappertz, Volker, Hayden, Michael R., Laufer, Ralph

“…Laquinimod is an oral drug currently being evaluated for the treatment of relapsing, remitting, and primary progressive multiple sclerosis and Huntington’s…”
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Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models by Naia, Luana, Rosenstock, Tatiana R., Oliveira, Ana M., Oliveira-Sousa, Sofia I., Caldeira, Gladys L., Carmo, Catarina, Laço, Mário N., Hayden, Michael R., Oliveira, Catarina R., Rego, A. Cristina

“…Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD + )-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism…”
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Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model by Lenoir, Sophie, Lahaye, Romane A., Vitet, Hélène, Scaramuzzino, Chiara, Virlogeux, Amandine, Capellano, Laetitia, Genoux, Aurélie, Gershoni-Emek, Noga, Geva, Michal, Hayden, Michael R., Saudou, Frédéric

“…Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in…”
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Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice by Milnerwood, Austen J., Gladding, Clare M., Pouladi, Mahmoud A., Kaufman, Alexandra M., Hines, Rochelle M., Boyd, Jamie D., Ko, Rebecca W.Y., Vasuta, Oana C., Graham, Rona K., Hayden, Michael R., Murphy, Timothy H., Raymond, Lynn A.

“…N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder…”
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ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity[S] by de Haan, Willeke, Bhattacharjee, Alpana, Ruddle, Piers, Kang, Martin H., Hayden, Michael R.

“…Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol…”
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CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches by Langbehn, Douglas R., Hayden, Michael R., Paulsen, Jane S.

“…CAG‐repeat length in the gene for HD is inversely correlated with age of onset (AOO). A number of statistical models elucidating the relationship between CAG…”
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