Search Results - "Hayden, Eric"

Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme by Hayden, Eric J., Ferrada, Evandro, Wagner, Andreas

“…Be prepared, with cryptic mutations Some mutations, known as cryptic mutations, have no observable effect on an organism's phenotype unless combined with other…”
Get full text

Spontaneous network formation among cooperative RNA replicators by Vaidya, Nilesh, Manapat, Michael L., Chen, Irene A., Xulvi-Brunet, Ramon, Hayden, Eric J., Lehman, Niles

“…The origins of life on Earth required the establishment of self-replicating chemical systems capable of maintaining and evolving biological information. In an…”
Get full text

Genotype network intersections promote evolutionary innovation by Bendixsen, Devin P, Collet, James, Østman, Bjørn, Hayden, Eric J

“…Evolutionary innovations are qualitatively novel traits that emerge through evolution and increase biodiversity. The genetic mechanisms of innovation remain…”
Get full text

Nanoscale Dynamics of Amyloid β‑42 Oligomers As Revealed by High-Speed Atomic Force Microscopy by Banerjee, Siddhartha, Sun, Zhiqiang, Hayden, Eric Y, Teplow, David B, Lyubchenko, Yuri L

“…Amyloid β-protein (Aβ) oligomers are emerging as potent neurotoxic species in Alzheimer’s disease pathogenesis. Detailed characterization of oligomer structure…”
Get full text

A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors by Townshend, Brent, Xiang, Joy S., Manzanarez, Gabriel, Hayden, Eric J., Smolke, Christina D.

“…Biosensors are key components in engineered biological systems, providing a means of measuring and acting upon the large biochemical space in living cells…”
Get full text

Amyloid β-protein oligomers and Alzheimer's disease by Hayden, Eric Y, Teplow, David B

“…The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic agents in Alzheimer's disease, has all but supplanted the amyloid…”
Get full text

From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology by Lindstrom, Michael R, Chavez, Manuel B, Gross-Sable, Elijah A, Hayden, Eric Y, Teplow, David B

“…Oligomers of the amyloid β -protein (A β ) have been implicated in the pathogenesis of Alzheimer’s disease (AD) through their toxicity towards neurons…”
Get full text

An alternative approach to nucleic acid memory by Dickinson, George D., Mortuza, Golam Md, Clay, William, Piantanida, Luca, Green, Christopher M., Watson, Chad, Hayden, Eric J., Andersen, Tim, Kuang, Wan, Graugnard, Elton, Zadegan, Reza, Hughes, William L.

“…DNA is a compelling alternative to non-volatile information storage technologies due to its information density, stability, and energy efficiency. Previous…”
Get full text

Dynamic RNA Fitness Landscapes of a Group I Ribozyme during Changes to the Experimental Environment by Peri, Gianluca, Gibard, Clémentine, Shults, Nicholas H, Crossin, Kent, Hayden, Eric J

“…Abstract Fitness landscapes of protein and RNA molecules can be studied experimentally using high-throughput techniques to measure the functional effects of…”
Get full text

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease by Koronyo-Hamaoui, Maya, Sheyn, Julia, Hayden, Eric Y, Li, Songlin, Fuchs, Dieu-Trang, Regis, Giovanna C, Lopes, Dahabada H J, Black, Keith L, Bernstein, Kenneth E, Teplow, David B, Fuchs, Sebastien, Koronyo, Yosef, Rentsendorj, Altan

“…Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein degrading enzyme, to brain resident microglia and peripheral…”
Get full text

Empirical analysis of RNA robustness and evolution using high-throughput sequencing of ribozyme reactions by Hayden, Eric J.

“…RNA molecules provide a realistic but tractable model of a genotype to phenotype relationship. This relationship has been extensively investigated…”
Get full text

Experimental Resurrection of Ancestral Mammalian CPEB3 Ribozymes Reveals Deep Functional Conservation by Bendixsen, Devin P., Pollock, Tanner B., Peri, Gianluca, Hayden, Eric J.

“…Abstract Self-cleaving ribozymes are genetic elements found in all domains of life, but their evolution remains poorly understood. A ribozyme located in the…”
Get full text

A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models by Rentsendorj, Altan, Sheyn, Julia, Fuchs, Dieu-Trang, Daley, David, Salumbides, Brenda C., Schubloom, Hannah E., Hart, Nadav J., Li, Songlin, Hayden, Eric Y., Teplow, David B., Black, Keith L., Koronyo, Yosef, Koronyo-Hamaoui, Maya

“…•Increased cerebral osteopontin correlates with decreased Aβ burden in AD models.•Osteopontin is predominantly expressed by cerebral-infiltrating monocytes and…”
Get full text

1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients by Mizwicki, Mathew T, Liu, Guanghao, Fiala, Milan, Magpantay, Larry, Sayre, James, Siani, Avi, Mahanian, Michelle, Weitzman, Rachel, Hayden, Eric Y, Rosenthal, Mark J, Nemere, Ilka, Ringman, John, Teplow, David B

“…As immune defects in amyloid-β (Aβ) phagocytosis and degradation underlie Aβ deposition and inflammation in Alzheimer's disease (AD) brain, better…”
Get more information

Negative Epistasis in Experimental RNA Fitness Landscapes by Bendixsen, Devin P., Østman, Bjørn, Hayden, Eric J.

“…Mutations and their effects on fitness are a fundamental component of evolution. The effects of some mutations change in the presence of other mutations, and…”
Get full text

Hidden intermediates in Mango III RNA aptamer folding revealed by pressure perturbation by Harish, Balasubramanian, Wang, Jinqiu, Hayden, Eric J., Grabe, Bastian, Hiller, Wolf, Winter, Roland, Royer, Catherine A.

“…Fluorescent RNA aptamers have the potential to enable routine quantitation and localization of RNA molecules and serve as models for understanding biologically…”
Get full text

DNA-PAINT Probe Modifications Support High-Resolution Imaging with Shorter Binding Domains by Piantanida, Luca, Dickinson, George D., Majikes, Jacob M., Clay, William, Liddle, J. Alexander, Andersen, Tim, Hayden, Eric J., Kuang, Wan, Hughes, William L.

“…DNA-based Points Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is an effective super resolution microscopy technique, and its optimization is…”
Get full text

Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases by Bilousova, Tina, Miller, Carol A, Poon, Wayne W, Vinters, Harry V, Corrada, Maria, Kawas, Claudia, Hayden, Eric Y, Teplow, David B, Glabe, Charles, Albay, Ricardo, Cole, Gregory M, Teng, Edmond, Gylys, Karen H

“…Amyloid-β (Aβ) and hyperphosphorylated tau (p-tau) aggregates form the two discrete pathologies of Alzheimer disease (AD), and oligomeric assemblies of each…”
Get full text

Amyloid β‑Protein C‑Terminal Fragments: Formation of Cylindrins and β‑Barrels by Do, Thanh D, LaPointe, Nichole E, Nelson, Rebecca, Krotee, Pascal, Hayden, Eric Y, Ulrich, Brittany, Quan, Sarah, Feinstein, Stuart C, Teplow, David B, Eisenberg, David, Shea, Joan-Emma, Bowers, Michael T

“…In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer’s disease (AD), it is essential to determine the structures…”
Get full text

Surface enhanced Raman spectroscopy distinguishes amyloid Β‐protein isoforms and conformational states by Yu, Xinke, Hayden, Eric Y., Xia, Ming, Liang, Owen, Cheah, Lisa, Teplow, David B., Xie, Ya‐Hong

“…Amyloid β‐protein (Aβ) self‐association is one process linked to the development of Alzheimer's disease (AD). Aβ peptides, including its most abundant forms,…”
Get full text