Search Results - "Hayashi, Takeru"

Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins by Hayashi, Takeru, Senda, Miki, Suzuki, Nobuhiro, Nishikawa, Hiroko, Ben, Chi, Tang, Chao, Nagase, Lisa, Inoue, Kaori, Senda, Toshiya, Hatakeyama, Masanori

“…Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the…”
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Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis by Nagase, Lisa, Hayashi, Takeru, Senda, Toshiya, Hatakeyama, Masanori

“…Infection with cagA -positive Helicobacter pylori is critically associated with the development of gastric cancer. The cagA -encoded CagA is delivered into…”
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Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1 by Ben, Chi, Wu, Xiaojing, Takahashi-Kanemitsu, Atsushi, Knight, Christopher Takaya, Hayashi, Takeru, Hatakeyama, Masanori

“…In addition to acting as a transcriptional co-activator, YAP1 directly mediates translocalization of the pro-oncogenic phosphatase SHP2 from the cytoplasm to…”
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Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein by Murata-Kamiya, Naoko, Kikuchi, Kenji, Hayashi, Takeru, Higashi, Hideaki, Hatakeyama, Masanori

“…When delivered into gastric epithelial cells via type IV secretion, Helicobacter pylori CagA perturbs host cell signaling and thereby promotes gastric…”
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YAP and TAZ, Hippo Signaling Targets, Act as a Rheostat for Nuclear SHP2 Function by Tsutsumi, Ryouhei, Masoudi, Mohammad, Takahashi, Atsushi, Fujii, Yumiko, Hayashi, Takeru, Kikuchi, Ippei, Satou, Yumeko, Taira, Masanori, Hatakeyama, Masanori

“…SHP2 is a ubiquitously expressed protein tyrosine phosphatase, deregulation of which is associated with malignant neoplasms and developmental disorders. SHP2…”
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Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization by Nishikawa, Hiroko, Christiany, Priscillia, Hayashi, Takeru, Iizasa, Hisashi, Yoshiyama, Hironori, Hatakeyama, Masanori

“…PAR1b is a cytoplasmic serine/threonine kinase that controls cell polarity and cell–cell interaction by regulating microtubule stability while mediating…”
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Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b by Nishikawa, Hiroko, Hayashi, Takeru, Arisaka, Fumio, Senda, Toshiya, Hatakeyama, Masanori

“…Chronic infection with cagA -positive Helicobacter pylori is the strongest risk factor for atrophic gastritis, peptic ulcers and gastric cancer. CagA, the…”
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Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA by Hayashi, Takeru, Senda, Miki, Morohashi, Hiroko, Higashi, Hideaki, Horio, Masafumi, Kashiba, Yui, Nagase, Lisa, Sasaya, Daisuke, Shimizu, Tomohiro, Venugopalan, Nagarajan, Kumeta, Hiroyuki, Noda, Nobuo N., Inagaki, Fuyuhiko, Senda, Toshiya, Hatakeyama, Masanori

“…The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. Upon delivery into…”
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Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling by Noda, Saori, Takahashi, Atsushi, Hayashi, Takeru, Tanuma, Sei-ichi, Hatakeyama, Masanori

“…SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also…”
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Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate by Hashi, Kana, Imai, Chihiro, Yahara, Koji, Tahmina, Kamrunnesa, Hayashi, Takeru, Azuma, Takeshi, Miyabe-Nishiwaki, Takako, Sato, Hideyuki, Matsuoka, Masao, Niimi, Sachi, Okamoto, Munehiro, Hatakeyama, Masanori

“…Helicobacter pylori cagA -positive strains are critically involved in the development of gastric cancer. Upon delivery into gastric epithelial cells via type…”
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Use of Multiple Cryoprotectants to Improve Diffraction Quality from Protein Crystals by Senda, Miki, Hayashi, Takeru, Hatakeyama, Masanori, Takeuchi, Koh, Sasaki, Atsuo T, Senda, Toshiya

“…Current X-ray sourcessuch as high-flux synchrotron radiation and XFELenable us to determine the tertiary structures of proteins at medium or low resolution…”
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Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells by KAMEOKA, Shoichiro, KAMEYAMA, Takeshi, HAYASHI, Takaya, SATO, Seiichi, OHNISHI, Naomi, HAYASHI, Takeru, MURATA-KAMIYA, Naoko, HIGASHI, Hideaki, HATAKEYAMA, Masanori, TAKAOKA, Akinori

“…More than 50% of people in the world are infected with Helicobacter pylori (H. pylori), which induces various gastric diseases. Especially, epidemiological…”
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Micro-demultiplexer of Coupled Resonator Optical Waveguide Fabricated by Microspheres by Mitsui, Tadashi, Wakayama, Yutaka, Onodera, Tsunenobu, Hayashi, Takeru, Ikeda, Naoki, Sugimoto, Yoshimasa, Takamasu, Tadashi, Oikawa, Hidetoshi

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Bacterial EPIYA effectors – Where do they come from? What are they? Where are they going? by Hayashi, Takeru, Morohashi, Hiroko, Hatakeyama, Masanori

“…Summary Recent studies have revealed a distinct class of bacterial effectors defined by the presence of EPIYA or EPIYA‐related motif. These bacterial EPIYA…”
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Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target by Arai, Junya, Hayakawa, Yoku, Tateno, Hiroaki, Murakami, Keita, Hayashi, Takeru, Hata, Masahiro, Matsushita, Yuki, Kinoshita, Hiroto, Abe, Sohei, Kurokawa, Ken, Oya, Yukiko, Tsuboi, Mayo, Ihara, Sozaburo, Niikura, Ryota, Suzuki, Nobumi, Iwata, Yusuke, Shiokawa, Toshiro, Shiomi, Chihiro, Uekura, Chie, Yamamoto, Keisuke, Fujiwara, Hiroaki, Kawamura, Satoshi, Nakagawa, Hayato, Mizuno, Seiya, Kudo, Takashi, Takahashi, Satoru, Ushiku, Tetsuo, Hirata, Yoshihiro, Fujii, Chifumi, Nakayama, Jun, Shibata, Shinsuke, Woods, Susan, Worthley, Daniel L., Hatakeyama, Masanori, Wang, Timothy C., Fujishiro, Mitsuhiro

“…Gastric cancer is often accompanied by a loss of mucin 6 (MUC6), but its pathogenic role in gastric carcinogenesis remains unclear. Muc6 knockout (Muc6−/−)…”
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Anaerobic crystallization for protein crystallography by Senda, Miki, Hayashi, Takeru, Hatakeyama, Masanori, Senda, Toshiya

“…Abstract only…”
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Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?: Bacterial EPIYA effector family by Hayashi, Takeru, Morohashi, Hiroko, Hatakeyama, Masanori

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Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling by Noda, Saori, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma, Masanori Hatakeyama

“…SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also…”
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Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein–Barr virus by Saju, Priya, Murata-Kamiya, Naoko, Hayashi, Takeru, Senda, Yoshie, Nagase, Lisa, Noda, Saori, Matsusaka, Keisuke, Funata, Sayaka, Kunita, Akiko, Urabe, Masayuki, Seto, Yasuyuki, Fukayama, Masashi, Kaneda, Atsushi, Hatakeyama, Masanori

“…Most if not all gastric cancers are associated with chronic infection of the stomach mucosa with Helicobacter pylori cagA -positive strains 1 – 4 …”
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Deregulation mechanism of SHP2 by CagA from Helicobacter pylori by Senda, Toshiya, Hayashi, Takeru, Suzuki, Nobuhiro, Nagase, Lisa, Senda, Miki, Hatakeyama, Masanori

“…Abstract only…”
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