Search Results - "Hayama, Noboru"

Asymmetric Hetero-Michael Additions to α,β-Unsaturated Carboxylic Acids by Multifunctional Boronic Acid Catalysts by Hayama, Noboru

“…Several direct asymmetric Michael additions to α,β-unsaturated carboxylic acids with integrated catalysts comprising chiral bifunctional thiourea and…”
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Chiral Integrated Catalysts Composed of Bifunctional Thiourea and Arylboronic Acid: Asymmetric Aza-Michael Addition of α,β-Unsaturated Carboxylic Acids by Hayama, Noboru, Azuma, Takumi, Kobayashi, Yusuke, Takemoto, Yoshiji

“…The first intermolecular asymmetric Michael addition of nitrogen-nucleophiles to α,β-unsaturated carboxylic acids was achieved through a new type of…”
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Bifunctional-Benzothiadiazine-Catalyzed Regio- and Stereoselective Aldol Reactions Using A 1,3-Acetonedicarboxylic Acid Monoester by Takemoto, Yoshiji, Tokuhiro, Yusuke, Hayama, Noboru, Kobayashi, Yusuke

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Rhodium-catalyzed Synthesis of Benzo[b]thiophene-3-carboxamides via Cyclization of (ortho-Alkynyl)phenyl Sulfides in the Presence of Isocyanates by Mizukami, Akiho, Tsugita, Maika, Shimora, Mako, Tanaka, Saki, Hayama, Noboru, Kimachi, Tetsutaro, Inamoto, Kiyofumi

“…A facile synthesis of benzo[b]thiophene-3-carboxamides from (ortho-alkynyl)phenyl methoxymethyl sulfides and isocyanates was realized. The method involves a…”
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多機能性ボロン酸触媒による不斉共役付加反応の開発とキラルスイッチ反応への展開 by 葉山, 登

“…「1. はじめに」 不斉共役付加反応は医薬品や天然物などにみられる不斉炭素を効率的に構築できるため, 重要な研究課題として位置づけられている. その中でも, α,β-不飽和カルボン酸1の共役付加体2は実用性の高いビルディングブロックであるが,…”
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CuI-Catalyzed Coupling Reactions of 4-Iodopyrazoles and Alcohols: Application toward Withasomnine and Homologs by Usami, Yoshihide, Kubo, Yumika, Takagaki, Toshiki, Kuroiwa, Nao, Ono, Jun, Nishikawa, Kohei, Nakamizu, Ayaka, Tatsui, Yuya, Harusawa, Shinya, Hayama, Noboru, Yoneyama, Hiroki

“…The direct 4-alkoxylation of 4-iodo-1 -pyrazoles with alcohols was achieved by a CuI-catalyzed coupling protocol. The optimal reaction conditions employed…”
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One-Pot Construction of Multiple Contiguous Chiral Centers Using Michael Addition of Chiral Amine by Ozeki, Minoru, Ochi, Shunsuke, Hayama, Noboru, Hosoi, Shinzo, Kajimoto, Tetsuya, Node, Manabu

“…Multiple contiguous chiral centers were constructed in one pot using three types of multistep reactions initiated with the Michael addition of…”
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Chiral Integrated Catalysts Composed of Bifunctional Thiourea and Arylboronic Acid : Asymmetric Aza-Michael Addition of α,β-Unsaturated Carboxylic Acids by Noboru Hayama, Takumi Azuma, Yusuke Kobayashi, Yoshiji Takemoto

“…The first intermolecular asymmetric Michael addition of nitrogen-nucleophiles to α,β-unsaturated carboxylic acids was achieved through a new type of…”
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Asymmetric Hetero-Michael Additions to α,β-Unsaturated Carboxylic Acids by Multifunctional Boronic Acid Catalysts by Hayama, Noboru

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Construction of Seven Contiguous Chiral Centers by Two Methods: Quadruple Michael Addition vs Stepwise Double‐Double Michael Addition Controlled by Adding Speed of Michael Acceptor by Ozeki, Minoru, Hayama, Noboru, Fukutome, Shintaro, Egawa, Honoka, Arimitsu, Kenji, Kajimoto , Tetsuya, Hosoi, Shinzo, Iwasaki, Hiroki, Kojima, Naoto, Node, Manabu, Yamashita, Masayuki

“…A tandem “quadruple” Michael addition reaction of (+)‐bornylamide with two equivalents of a Michael acceptor having two α,β‐unsaturated ester moieties…”
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The first enantioselective synthesis of imino-deoxydigitoxose and protected imino-digitoxose by using l-threonine aldolase-catalyzed aldol condensation by Nishiyama, Toshihiro, Kajimoto, Tetsuya, Mohile, Swapnil S., Hayama, Noboru, Otsuda, Teppei, Ozeki, Minoru, Node, Manabu

“…The first enantioselective synthesis of protected imino-digitoxose (−)- 16 was attained starting with a synthetic intermediate of polyoxin C prepared by the…”
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A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of α,β-Unsaturated Amides and Esters by Kobayashi, Yusuke, Taniguchi, Yamato, Hayama, Noboru, Inokuma, Tsubasa, Takemoto, Yoshiji

“…Tuning the organocatalyst: An unprecedented enantioselective intramolecular oxa‐Michael reaction of unactivated α,β‐unsaturated amides and esters catalyzed by…”
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Identification of novel metabolites of abiraterone in human serum and their metabolic pathways by Horiyama, Shizuyo, Hayama, Noboru, Yoneyama, Hiroki, Usami, Yoshihide, Haginaka, Jun

“…Two novel abiraterone (Abi, 3β-OH-Abi) metabolites in human serum were identified as 3α-OH-Abi and Δ 5 -Abi (D5A). Both metabolites were confirmed by their…”
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Mechanistic Insight into Asymmetric Hetero-Michael Addition of α,β-Unsaturated Carboxylic Acids Catalyzed by Multifunctional Thioureas by Hayama, Noboru, Kuramoto, Ryuta, Földes, Tamás, Nishibayashi, Kazuya, Kobayashi, Yusuke, Pápai, Imre, Takemoto, Yoshiji

“…Carboxylic acids and their corresponding carboxylate anions are generally utilized as Brønsted acids/bases and oxygen nucleophiles in organic synthesis…”
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Asymmetric hetero-Michael addition to α,β-unsaturated carboxylic acids using thiourea–boronic acid hybrid catalysts by Hayama, Noboru, Kobayashi, Yusuke, Takemoto, Yoshiji

“…The first catalytic asymmetric Michael addition of heteroatomic nucleophiles to α,β-unsaturated carboxylic acids is summarized. Direct Michael addition is one…”
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A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst by Hayama, Noboru, Kobayashi, Yusuke, Sekimoto, Eriko, Miyazaki, Anna, Inamoto, Kiyofumi, Kimachi, Tetsutaro, Takemoto, Yoshiji

“…An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine…”
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A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst† †Electronic supplementary information (ESI) available: Experimental procedures, spectroscopic data, copies of 1H and 13C NMR spectra, and HPLC chromatograms. See DOI: 10.1039/d0sc01729a by Hayama, Noboru, Kobayashi, Yusuke, Sekimoto, Eriko, Miyazaki, Anna, Inamoto, Kiyofumi, Kimachi, Tetsutaro, Takemoto, Yoshiji

“…An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine…”
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Chiral Integrated Catalysts Composed of Bifunctional Thiourea and Arylboronic Acid by Hayama, Noboru, Azuma, Takumi, Kobayashi, Yusuke, Takemoto, Yoshiji

“…The first intermolecular asymmetric Michael addition of nitrogen-nucleophiles to α,β-unsaturated carboxylic acids was achieved through a new type of…”
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A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of [alpha],[beta]-Unsaturated Amides and Esters by Kobayashi, Yusuke, Taniguchi, Yamato, Hayama, Noboru, Inokuma, Tsubasa, Takemoto, Yoshiji

“…Tuning the organocatalyst: An unprecedented enantioselective intramolecular oxa-Michael reaction of unactivated α,[beta]-unsaturated amides and esters…”
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Inhibition of angiogenesis and tumor growth by a novel 1,4‐naphthoquinone derivative by Murota, Hiroko, Shinya, Tomohiro, Nishiuchi, Arisa, Sakanaka, Mariko, Toda, Ken‐ichi, Ogata, Tokutaro, Hayama, Noboru, Kimachi, Tetsutaro, Takahashi, Satoru

“…Hit, Lead & Candidate Discovery Antiangiogenesis therapy is a promising way for treatment of solid cancers, and many angiogenesis inhibitors that target…”
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