Search Results - "Hayakawa, Kunihiro"

MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling by Hayakawa, Kunihiro, Kawasaki, Mikiko, Hirai, Takuya, Yoshida, Yuko, Tsushima, Hiroshi, Fujishiro, Maki, Ikeda, Keigo, Morimoto, Shinji, Takamori, Kenji, Sekigawa, Iwao

“…MicroRNA (miRNA) is small RNA of 20 to 22 nucleotides in length and is stably present in plasma. Regulating the expression of miRNA taken into cells has been…”
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Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP) by Tagawa, Yasuhiro, Hiramatsu, Nobuhiko, Kasai, Ayumi, Hayakawa, Kunihiro, Okamura, Maro, Yao, Jian, Kitamura, Masanori

“…In this report, we investigated a role of endoplasmic reticulum (ER) stress in cigarette smoke (CS)-induced apoptosis of human bronchial epithelial cells…”
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Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C–C motif chemokine receptor 7 in skin dendritic cells by Yoshida, Yuko, Hayakawa, Kunihiro, Fujishiro, Maki, Ikeda, Keigo, Tsushima, Hiroshi, Hirai, Takuya, Kawasaki, Mikiko, Tominaga, Mitsutoshi, Suga, Yasushi, Takamori, Kenji, Watanabe, Yoshifumi, Sekigawa, Iwao, Morimoto, Shinji

“…DNA methylation is an epigenetic modification that regulates gene transcription. DNA methyltransferase 1 (DNMT1) plays an important role in DNA methylation…”
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Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt by Nakajima, Shotaro, Hiramatsu, Nobuhiko, Hayakawa, Kunihiro, Saito, Yukinori, Kato, Hironori, Huang, Tao, Yao, Jian, Paton, Adrienne W., Paton, James C., Kitamura, Masanori

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Involvement of Selective Reactive Oxygen Species Upstream of Proapoptotic Branches of Unfolded Protein Response by Yokouchi, Makiko, Hiramatsu, Nobuhiko, Hayakawa, Kunihiro, Okamura, Maro, Du, Shuqi, Kasai, Ayumi, Takano, Yosuke, Shitamura, Akihiro, Shimada, Tsuyoshi, Yao, Jian, Kitamura, Masanori

“…Cadmium triggers apoptosis of LLC-PK1 cells through induction of endoplasmic reticulum (ER) stress. We found that cadmium caused generation of reactive oxygen…”
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JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation by Ikeda, Keigo, Hayakawa, Kunihiro, Fujishiro, Maki, Kawasaki, Mikiko, Hirai, Takuya, Tsushima, Hiroshi, Miyashita, Tomoko, Suzuki, Satoshi, Morimoto, Shinji, Tamura, Naoto, Takamori, Kenji, Ogawa, Hideoki, Sekigawa, Iwao

“…We previously reported that JAK-STAT-pathway mediated regulation of IFN-regulatory factor genes could play an important role in SLE pathogenesis. Here, we…”
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Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ) by Dankers, Wendy, Northcott, Melissa, Bennett, Taylah, D'Cruz, Akshay, Sherlock, Rochelle, Gearing, Linden J, Hertzog, Paul, Russ, Brendan, Miceli, Iolanda, Scheer, Sebastian, Fujishiro, Maki, Hayakawa, Kunihiro, Ikeda, Keigo, Morand, Eric F, Jones, Sarah A

“…SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for…”
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Access-Related Infections Involving the Buttonhole Technique by Toma, Shigeki, Shinzato, Takahiro, Hayakawa, Kunihiro

“…In this study, we discuss a mechanism of development of access-related Staphylococcus aureus infections in patients on buttonhole (BH) method and logically…”
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Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization by Tamehiro, Norimasa, Nishida, Kyoko, Sugita, Yu, Hayakawa, Kunihiro, Oda, Hiroyo, Nitta, Takeshi, Nakano, Miwa, Nishioka, Akiko, Yanobu-Takanashi, Reiko, Goto, Motohito, Okamura, Tadashi, Adachi, Reiko, Kondo, Kazunari, Morita, Akimichi, Suzuki, Harumi

“…Ras homolog gene family H (RhoH) is a membrane-bound adaptor protein involved in proximal T-cell receptor signaling. Therefore RhoH plays critical roles in the…”
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Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis by Hirai, Takuya, Ikeda, Keigo, Tsushima, Hiroshi, Fujishiro, Maki, Hayakawa, Kunihiro, Yoshida, Yuko, Morimoto, Shinji, Yamaji, Ken, Takasaki, Yoshinari, Takamori, Kenji, Tamura, Naoto, Sekigawa, Iwao

“…MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The…”
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Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes by Patrick, Michael S, Oda, Hiroyo, Hayakawa, Kunihiro, Sato, Yoshinori, Eshima, Koji, Kirikae, Teruo, Iemura, Shun-ichiro, Shirai, Mutsunori, Abe, Takaya, Natsume, Tohru, Sasazuki, Takehiko, Suzuki, Harumi

“…T cells develop in the thymus through positive and negative selection, which are responsible for shaping the T cell receptor (TCR) repertoire. To elucidate the…”
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Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder by Sawada, Norifumi, Yao, Jian, Hiramatsu, Nobuhiko, Hayakawa, Kunihiro, Araki, Isao, Takeda, Masayuki, Kitamura, Masanori

“…In bladder outlet obstruction (BOO), mechanical stress and ischemia/hypoxia are implicated in structural and functional alterations of the urinary bladder…”
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Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis by Miyashita, Tomoko, Morimoto, Shinji, Fujishiro, Maki, Hayakawa, Kunihiro, Suzuki, Satoshi, Ikeda, Keigo, Miyazawa, Keiji, Morioka, Megumi, Takamori, Kenji, Ogawa, Hideoki, Sekigawa, Iwao, Takasaki, Yoshinari

“…We previously reported the importance of connective tissue growth factor (CTGF) in rheumatoid arthritis (RA). CTGF contains four distinct modules connected in…”
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Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis by Tsushima, Hiroshi, Morimoto, Shinji, Fujishiro, Maki, Yoshida, Yuko, Hayakawa, Kunihiro, Hirai, Takuya, Miyashita, Tomoko, Ikeda, Keigo, Yamaji, Ken, Takamori, Kenji, Takasaki, Yoshinari, Sekigawa, Iwao, Tamura, Naoto

“…We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA)…”
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Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis by Suzuki, Satoshi, Morimoto, Shinji, Fujishiro, Maki, Kawasaki, Mikiko, Hayakawa, Kunihiro, Miyashita, Tomoko, Ikeda, Keigo, Miyazawa, Keiji, Yanagida, Mitsuaki, Takamori, Kenji, Ogawa, Hideoki, Sekigawa, Iwao, Takasaki, Yoshinari

“…Abstract Objective: We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA)…”
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Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway by Takano, Yosuke, Yamauchi, Kozue, Hayakawa, Kunihiro, Hiramatsu, Nobuhiko, Kasai, Ayumi, Okamura, Maro, Yokouchi, Makiko, Shitamura, Akihiro, Yao, Jian, Kitamura, Masanori

“…Expression of nephrin, a crucial component of the glomerular slit diaphragm, is downregulated in patients with proteinuric glomerular diseases. Using…”
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Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection by Ogawa, Masahiro, Okamura, Tadashi, Ishikura, Shuhei, Doi, Keiko, Matsuzaki, Hiroshi, Tanaka, Yoko, Ota, Takeharu, Hayakawa, Kunihiro, Suzuki, Harumi, Tsunoda, Toshiyuki, Sasazuki, Takehiko, Shirasawa, Senji

“…The human ZFAT gene was originally identified as a susceptibility gene for autoimmune thyroid disease. Mouse Zfat is a critical transcriptional regulator for…”
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Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation by Hayakawa, Kunihiro, Hiramatsu, Nobuhiko, Okamura, Maro, Yamazaki, Hiroaki, Nakajima, Shotaro, Yao, Jian, Paton, Adrienne W, Paton, James C, Kitamura, Masanori

“…Acute endoplasmic reticulum (ER) stress causes induction of inflammatory molecules via activation of NF-kappaB. However, we found that, under ER stress…”
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Blockade of the Dioxin Pathway by Herbal Medicine Formula Bupleuri Minor: Identification of Active Entities for Suppression of AhR Activation by Kasai, Ayumi, Hiramatsu, Nobuhiko, Hayakawa, Kunihiro, Yao, Jian, Kitamura, Masanori

“…Environmental pollutants including dioxins activate the aryl hydrocarbon receptor (AhR) and cause a wide range of pathologies. Development of AhR antagonists…”
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Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice by Hiramatsu, Nobuhiko, Kasai, Ayumi, Du, Shuqi, Takeda, Masayuki, Hayakawa, Kunihiro, Okamura, Maro, Yao, Jian, Kitamura, Masanori

“…Endoplasmic reticulum (ER) stress-responsive alkaline phosphatase (ES-TRAP) serves as a sensitive indicator for ER stress. In response to heavy metals…”
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