Search Results - "HayGlass, Kent"

Vitamin D [1,25(OH)2D3] Differentially Regulates Human Innate Cytokine Responses to Bacterial versus Viral Pattern Recognition Receptor Stimuli by Fitch, Natascha, Becker, Allan B, HayGlass, Kent T

“…Vitamin D plays multiple roles in regulation of protective and maladaptive immunity. Although epidemiologic studies link poor in vivo 25(OH)D status to…”
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In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory? by Graham, Caroline, Chooniedass, Rishma, Stefura, William P, Becker, Allan B, Sears, Malcolm R, Turvey, Stuart E, Mandhane, Piush J, Subbarao, Padmaja, HayGlass, Kent T

“…Changes in maternal innate immunity during healthy human pregnancy are not well understood. Whether basal immune status in vivo is largely unaffected by…”
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High Spinal Anesthesia Enhances Anti-Inflammatory Responses in Patients Undergoing Coronary Artery Bypass Graft Surgery and Aortic Valve Replacement: Randomized Pilot Study by Lee, Trevor W R, Kowalski, Stephen, Falk, Kelsey, Maguire, Doug, Freed, Darren H, HayGlass, Kent T

“…Cardiac surgery induces many physiologic changes including major inflammatory and sympathetic nervous system responses. Here, we conducted a single-centre…”
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The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma by Subbarao, Padmaja, Anand, Sonia S, Becker, Allan B, Befus, A Dean, Brauer, Michael, Brook, Jeffrey R, Denburg, Judah A, HayGlass, Kent T, Kobor, Michael S, Kollmann, Tobias R, Kozyrskyj, Anita L, Lou, W Y Wendy, Mandhane, Piushkumar J, Miller, Gregory E, Moraes, Theo J, Pare, Peter D, Scott, James A, Takaro, Tim K, Turvey, Stuart E, Duncan, Joanne M, Lefebvre, Diana L, Sears, Malcolm R

“…The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We…”
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Improved Methods for Quantifying Human Chemokine and Cytokine Biomarker Responses: Ultrasensitive ELISA and Meso Scale Electrochemiluminescence Assays by Stefura, William P, Graham, Caroline, Lotoski, Larisa, HayGlass, Kent T

“…ELISAs and similar immunoassays are a backbone of biomedical research and clinical practice. Here we review the major factors to consider in the development…”
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Influence of socioeconomic status trajectories on innate immune responsiveness in children by Azad, Meghan B, Lissitsyn, Yuri, Miller, Gregory E, Becker, Allan B, HayGlass, Kent T, Kozyrskyj, Anita L

“…Lower socioeconomic status (SES) is consistently associated with poor health, yet little is known about the biological mechanisms underlying this inequality…”
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A randomized controlled trial on the effects of goal-directed therapy on the inflammatory response open abdominal aortic aneurysm repair by Funk, Duane J, HayGlass, Kent T, Koulack, Joshua, Harding, Greg, Boyd, April, Brinkman, Ryan

“…Goal-directed therapy (GDT) has been shown in numerous studies to decrease perioperative morbidity and mortality. The mechanism of benefit of GDT, however, has…”
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Acute Kidney Injury in Patients Undergoing Open Abdominal Aortic Aneurysm Repair: A Pilot Observational Trial by Brinkman, Ryan, MD, FRCPC, HayGlass, Kent T., PhD, Mutch, W.A.C., MD, FRCPC, Funk, Duane J., MD, FRCPC

“…Objectives Acute kidney injury (AKI) is a frequent complication after open repair of abdominal aortic aneurysms (AAA). Little research has been done to…”
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Mass Spectrometry–Based Proteomic Analysis of Urine in Acute Kidney Injury Following Cardiopulmonary Bypass: A Nested Case-Control Study by Ho, Julie, MD, Lucy, Malcolm, BSc, Krokhin, Oleg, PhD, Hayglass, Kent, PhD, Pascoe, Edward, MD, Darroch, Gayle, RN, Rush, David, MD, Nickerson, Peter, MD, Rigatto, Claudio, MD, Reslerova, Martina, MD, PhD

“…Background The early evolution of acute kidney injury (AKI) in humans is difficult to study noninvasively. We hypothesized that urine proteomics could provide…”
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Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1‐like and enhanced T helper type 2‐like immune balance in humans by Orihara, Kanami, Odemuyiwa, Solomon O., Stefura, William P., Ilarraza, Ramses, HayGlass, Kent T., Moqbel, Redwan

“…Summary Given the pivotal roles that CD4+ T cell imbalance plays in human immune disorders, much interest centres on better understanding influences that…”
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Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice by Nashed, Baher, Yeganeh, Behzad, HayGlass, Kent T, Moghadasian, Mohammed H

“…Dietary phytosterols significantly reduce atherosclerosis in apo E-deficient mice. Because atherosclerosis is a chronic inflammatory disease, we investigated…”
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Elevated antigen-driven IL-9 responses are prominent in peanut allergic humans by Xie, Jungang, Lotoski, Larisa C, Chooniedass, Rishma, Su, Ruey-Chyi, Simons, F Estelle R, Liem, Joel, Becker, Allan B, Uzonna, Jude, HayGlass, Kent T

“…Food allergies, and peanut allergy in particular, are leading causes of anaphylactic fatalities worldwide. The immune mechanisms that underlie food allergy…”
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Quantifying Human Innate Cytokine and Chemokine Responses Ex Vivo via Pattern Recognition Receptor Stimulation by Fitch, Natascha, Marshall, Stephanie J, Stefura, William P, Chooniedass, Rishma, Becker, Allan B, HayGlass, Kent T

“…Linkages between human innate immune capacity, the environment in which we live, and the development of clinical tolerance versus a spectrum of disease…”
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Continued Exposure to Maternal Distress in Early Life Is Associated with an Increased Risk of Childhood Asthma by Kozyrskyj, Anita L, Mai, Xiao-Mei, McGrath, Patrick, HayGlass, Kent T, Becker, Allan B, MacNeil, Brian

“…Evidence is emerging that exposure to maternal distress in early life plays a causal role in the development of childhood asthma. Because much of the data are…”
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Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children by Su, Ruey-Chyi, PhD, Becker, Allan B., MD, Kozyrskyj, Anita L., PhD, HayGlass, Kent T., PhD

“…[...]the net in vivo histone (de)acetylation activity (expressed as the ratio of HDAC/HAT activity) is skewed toward increased histone acetylation in allergic…”
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Validation of Urinary CXCL10 As a Marker of Borderline, Subclinical, and Clinical Tubulitis by HO, Julie, RUSH, David N, KARPINSKI, Martin, STORSLEY, Leroy, GIBSON, Ian W, BESTLAND, Jennifer, GAO, Ang, STEFURA, William, HAYGLASS, Kent T, NICKERSON, Peter W

“…Renal allograft injury secondary to subclinical and clinical tubulitis remains an important cause of allograft fibrosis and loss despite modern…”
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Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth by Dreger, Lisa C., MA, Kozyrskyj, Anita L., PhD, HayGlass, Kent T., PhD, Becker, Allan B., MD, MacNeil, Brian J., PhD

“…Background Existing evidence supports associations between exposure to maternal distress and the development of childhood asthma, between exposure to maternal…”
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NMDA Receptor Triggering Leads CD4+ T Cells Cytokine Balance Towards Type 2 Dominant by Orihara, Kanami, PhD, HayGlass, Kent T., PhD, Matsuda, Akio, PhD, Saito, Hirohisa, MD, PhD, Matsumoto, Kenji, MD, PhD

“…[...]we aimed in this study to investigate if NMDA receptor triggering influences on cytokine secretion balance from CD4+ T cells…”
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TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus by Douville, Renée N, Lissitsyn, Yuriy, Hirschfeld, Aaron F, Becker, Allan B, Kozyrskyj, Anita L, Liem, Joel, Bastien, Nathalie, Li, Yan, Victor, Rachel E, Sekhon, Mehtab, Turvey, Stuart E, HayGlass, Kent T

“…A broad variety of natural environmental stimuli, genotypic influences and timing all contribute to expression of protective versus maladaptive immune…”
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Epigenetic regulation of established human type 1 versus type 2 cytokine responses by Su, Ruey-Chyi, PhD, Becker, Allan B., MD, Kozyrskyj, Anita L., PhD, HayGlass, Kent T., PhD

“…Background Multiple biologic factors influence maintenance of immunologic responsiveness. Here, we studied whether epigenetics has a regulatory function in…”
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