Search Results - "Hay, Trevor"

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression by Mohamed, Noha-Ehssan, Hay, Trevor, Reed, Karen R, Smalley, Matthew J, Clarke, Alan R

“…Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated…”
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Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model by Tornillo, Giusy, Warrington, Lauren, Kendrick, Howard, Higgins, Adam T, Hay, Trevor, Beck, Sam, Smalley, Matthew J

“…LYN kinase is expressed in BRCA1 loss-of-function-dependent mouse mammary tumours, in the cells of origin of such tumours, and in human breast cancer…”
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Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc by Williams, Jason S, Higgins, Adam T, Stott, Katie J, Thomas, Carly, Farrell, Lydia, Bonnet, Cleo S, Peneva, Severina, Derrick, Anna V, Hay, Trevor, Wang, Tianqi, Morgan, Claire, Dwyer, Sarah, D'Ambrogio, Joshua, Hogan, Catherine, Smalley, Matthew J, Parry, Lee, Dyson, Paul

“…Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to…”
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Keeping connected: a review of the research relationship by Moss, Julianne, Hay, Trevor

“…In this paper, some key findings of the Keeping Connected project are discussed in light of the methodological challenges of developing an analytical approach…”
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Hypophosphorylation of Mdm2 Augments p53 Stability by Blattner, Christine, Hay, Trevor, Meek, David W., Lane, David P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ethnography Versus Case Study - Positioning Research and Researchers by White, Julie, Drew, Sarah, Hay, Trevor

“…In this paper we narrate a story of working on a large project funded by an Australian Research Council Linkage grant the 'Keeping Connected: Young People,…”
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Teenagers And Chronic Condition-Self Management: Much More Than Medical Aspects Of Self-Care by Drew, Sarah, PhD, White, Julie, PhD, Ferguson, Peter, PhD, Hay, Trevor, PhD

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Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains by Hay, Trevor J, Meek, David W

“…The MDM2 oncoprotein is a negative regulatory partner of the p53 tumour suppressor. MDM2 mediates ubiquitination of p53 and targets the protein to the…”
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Hepatic progenitor cells of biliary origin with liver repopulation capacity by Lu, Wei-Yu, Bird, Thomas G., Boulter, Luke, Tsuchiya, Atsunori, Cole, Alicia M., Hay, Trevor, Guest, Rachel V., Wojtacha, Davina, Man, Tak Yung, Mackinnon, Alison, Ridgway, Rachel A., Kendall, Timothy, Williams, Michael J., Jamieson, Thomas, Raven, Alex, Hay, David C., Iredale, John P., Clarke, Alan R., Sansom, Owen J., Forbes, Stuart J.

“…Hepatocytes and cholangiocytes self-renew following liver injury. Following severe injury hepatocytes are increasingly senescent, but whether hepatic…”
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NOTCH and AKT Signalling Interact to Drive Mammary Tumour Heterogeneity by Ordonez, Liliana, Tornillo, Giusy, Kendrick, Howard, Hay, Trevor, Smalley, Matthew John

“…A better understanding of the mechanisms generating tumour heterogeneity will allow better targeting of current therapies, identify potential resistance…”
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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence by Bird, Thomas G, Müller, Miryam, Boulter, Luke, Vincent, David F, Ridgway, Rachel A, Lopez-Guadamillas, Elena, Lu, Wei-Yu, Jamieson, Thomas, Govaere, Olivier, Campbell, Andrew D, Ferreira-Gonzalez, Sofía, Cole, Alicia M, Hay, Trevor, Simpson, Kenneth J, Clark, William, Hedley, Ann, Clarke, Mairi, Gentaz, Pauline, Nixon, Colin, Bryce, Steven, Kiourtis, Christos, Sprangers, Joep, Nibbs, Robert J B, Van Rooijen, Nico, Bartholin, Laurent, McGreal, Steven R, Apte, Udayan, Barry, Simon T, Iredale, John P, Clarke, Alan R, Serrano, Manuel, Roskams, Tania A, Sansom, Owen J, Forbes, Stuart J

“…Liver injury results in rapid regeneration through hepatocyte proliferation and hypertrophy. However, after acute severe injury, such as acetaminophen…”
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Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir,eAEbortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E, Dunlop, Elaine A, Seifan, Sara, McCann, Henry D, Hay, Trevor, Parfitt, Geraint J, Jones, Ashley T

“…Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis…”
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Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2 -mutant mammary tumours by Ordonez, Liliana D, Hay, Trevor, McEwen, Robert, Polanska, Urszula M, Hughes, Adina, Delpuech, Oona, Cadogan, Elaine, Powell, Steve, Dry, Jonathan, Tornillo, Giusy, Silcock, Lucy, Leo, Elisabetta, O'Connor, Mark J, Clarke, Alan R, Smalley, Matthew J

“…Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have…”
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Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark, Tee, Andrew R.

“…Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis…”
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Correction: Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir–bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death by Johnson, Charlotte E., Dunlop, Elaine A., Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J., Jones, Ashley T., Giles, Peter J., Shen, Ming H., Sampson, Julian R., Errington, Rachel J., Davies, D. Mark, Tee, Andrew R.

“…This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper…”
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RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models by Tangudu, Naveen K, Verma, Vinod K, Clemons, Tristan D, Beevi, Syed S, Hay, Trevor, Mahidhara, Ganesh, Raja, Meera, Nair, Rekha A, Alexander, Liza E, Patel, Anant B, Jose, Jedy, Smith, Nicole M, Zdyrko, Bogdan, Bourdoncle, Anne, Luzinov, Igor, Iyer, K Swaminathan, Clarke, Alan R, Dinesh Kumar, Lekha

“…In this article, we report the development and preclinical validation of combinatorial therapy for treatment of cancers using RNA interference (RNAi). RNAi…”
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Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin by HAY, Trevor, MATTHEW, James R, CLARKE, Alan R, PIETZKA, Lucie, LAU, Alan, CRANSTON, Aaron, NYGREN, Anders O. H, DOUGLAS-JONES, Anthony, SMITH, Graeme C. M, MARTIN, Niall M. B, O'CONNOR, Mark

“…Germ-line heterozygosity of the BRCA2 gene in women predisposes to breast and ovarian cancers. Successful therapies targeted specifically at these neoplasms…”
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Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy by HAY, Trevor, JENKINS, Helen, SANSOM, Owen J, MARTIN, Niall M. B, SMITH, Graeme C. M, CLARKE, Alan R

“…The genes encoding the BRCA1 and BRCA2 tumor suppressors are the most commonly mutated in human familial breast cancers. Both have separate roles in the…”
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Ethnography versus case study by Julie White, Sarah Drew, Trevor Hay

“…This paper narrates a story of working on a large project funded by an Australian Research Council Linkage grant - the 'Keeping Connected: Young People,…”
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Ethnography versus case study by Julie White, Sarah Drew, Trevor Hay

“…This paper narrates a story of working on a large project funded by an Australian Research Council Linkage grant - the 'Keeping Connected: Young People,…”
Get full text