Search Results - "Hay, Douglas W.P."

In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe- d -Ala-Gly-Arg- d -Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2 ) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator by Edelson, Jeffrey D, Makhlina, Marie, Silvester, Kevin R, Vengurlekar, Shailesh S, Chen, Xiaomei, Zhang, Jie, Koziol-White, Cynthia J, Cooper, Philip R, Hallam, Trevor J, Hay, Douglas W.P, Panettieri, Reynold A

“…Abstract The pharmacological and airways relaxant profiles of PL-3994 (Hept-cyclo(Cys-His-Phe- d -Ala-Gly-Arg- d -Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg…”
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Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor by Sarau, H M, Ames, R S, Chambers, J, Ellis, C, Elshourbagy, N, Foley, J J, Schmidt, D B, Muccitelli, R M, Jenkins, O, Murdock, P R, Herrity, N C, Halsey, W, Sathe, G, Muir, A I, Nuthulaganti, P, Dytko, G M, Buckley, P T, Wilson, S, Bergsma, D J, Hay, D W

“…The cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory disorders, in particular asthma, for which the CysLT receptor…”
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Interleukin-8 receptor antagonists in pulmonary diseases by Hay, Douglas W.P, Sarau, Henry M

“…Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung…”
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Endothelin‐1‐induced potentiation of human airway smooth muscle proliferation: an ETA receptor‐mediated phenomenon by Panettieri, Reynold A., Goldie, Roy G., Rigby, Paul J., Eszterhas, Andrew J., Hay, Douglas W.P.

“…1 . In this study the mitogenic effects in human cultured tracheal smooth muscle cells of endothelin‐1 (ET‐1), ET‐3, and sarafotoxin S6c (S6c), the ETB…”
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Molecular and pharmacological characterization of the murine tachykinin NK3 receptor by SARAU, Henry M, FEILD, John A, GIARDINA, Giuseppe A. M, HAY, Douglas W. P, AMES, Robert S, FOLEY, James J, NUTHULAGANTI, Parvathi, SCHMIDT, Dulcie B, BUCKLEY, Peter T, ELSHOURBAGY, Nabil A, BRAWNER, Mary E, LUTTMANN, Mark A

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The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo by Chiang, Nan, Serhan, Charles N, Dahlén, Sven-Erik, Drazen, Jeffrey M, Hay, Douglas W P, Rovati, G Enrico, Shimizu, Takao, Yokomizo, Takehiko, Brink, Charles

“…Lipoxins (LXs) and aspirin-triggered LX (ATL) are trihydroxytetraene-containing eicosanoids generated from arachidonic acid that are distinct in structure,…”
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Investigation of SAR requirements of SR 142801 through an indexed combinatorial library in solution by Raveglia, Luca F, Vitali, Mauro, Artico, Marco, Graziani, Davide, Hay, Douglas W.P, Luttmann, Mark A, Mena, Renzo, Pifferi, Giorgio, Giardina, Giuseppe A.M

“…To rapidly gain information on structure-activity relationship (SAR) requirements of the human neurokinin 3 (hNK-3) receptor antagonist SR 142801, an indexed…”
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Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases by Salmon, Michael, Luttmann, Mark A, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Burman, Miriam, Webb, Edward F, DeHaas, Christopher J, Kotzer, Charles J, Barrett, Victoria J, Slack, Robert J, Sarau, Henry M, Palovich, Michael R, Lainé, Dramane I, Hay, Douglas W P, Rumsey, William L

“…Activation of muscarinic subtype 3 (M3) muscarinic cholinergic receptors (mAChRs) increases airway tone, whereas its blockade improves lung function and…”
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Targeted Disruption of the Endothelin-B-Receptor Gene Attenuates Inflammatory Nociception and Cutaneous Inflammation in Mice by Griswold, Don E, Douglas, Stephen A, Martin, Lenox D, Davis, Gregg T, Davis, Laura, Ao, Zhaohui, Luttmann, Mark A, Pullen, Mark, Nambi, Ponnal, Hay, Douglas W.P, Ohlstein, Eliot H

“…Endothelin-1 (ET-1) has been suggested to have a potential function as an inflammatory mediator. The study reported here assessed the putative…”
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Targeted Disruption of the Endothelin-B-Receptor Gene Attenuates Inflammatory Nociception and Cutaneous Inflammation in Mice by Griswold, Don E, Douglas, Stephen A, Martin, Lenox D, Davis, Gregg T, Davis, Laura, Ao, Zhaohui, Luttmann, Mark A, Pullen, Mark, Nambi, Ponnal, Hay, Douglas W.P, Ohlstein, Eliot H

“…Endothelin-1 (ET-1) has been suggested to have a potential function as an inflammatory mediator. The study reported here assessed the putative…”
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Food restriction-mediated adrenal influences on antigen-induced bronchoconstriction and airway eosinophil influx in the guinea pig by Underwood, D C, Matthews, J K, Osborn, R R, Hay, D W

“…The aim of this study was to measure the effects of food restriction on antigen-induced bronchoconstriction and inflammatory cell influx in guinea pigs and to…”
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International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors by Brink, Charles, Dahlén, Sven-Erik, Drazen, Jeffrey, Evans, Jilly F, Hay, Douglas W P, Nicosia, Simonetta, Serhan, Charles N, Shimizu, Takao, Yokomizo, Takehiko

“…The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic acid. Their diverse and potent actions are associated with specific…”
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SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung by Underwood, D C, Osborn, R R, Bochnowicz, S, Webb, E F, Rieman, D J, Lee, J C, Romanic, A M, Adams, J L, Hay, D W, Griswold, D E

“…The effects of a second generation p38 mitogen-activated protein kinase (MAPK) inhibitor, SB 239063…”
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Relaxation of guinea‐pig tracheal smooth muscle to arachidonate is converted to contraction following epithelium removal by Farmer, Stephen G., Hay, Douglas W.P., Raeburn, David, Fedan, Jeffrey S.

“…1 The effect of epithelium removal on responses of guinea‐pig isolated trachealis to sodium arachidonate has been examined. 2 Arachidonate (100 μm) caused…”
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A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit by Podolin, Patricia L, Bolognese, Brian J, Foley, James J, Schmidt, Dulcie B, Buckley, Peter T, Widdowson, Katherine L, Jin, Qi, White, John R, Lee, Judithann M, Goodman, Richard B, Hagen, Tonja R, Kajikawa, Osamu, Marshall, Lisa A, Hay, Douglas W. P, Sarau, Henry M

“…Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheumatoid arthritis. The effects of IL-8 and its related ligands…”
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SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence by Underwood, D C, Osborn, R R, Kotzer, C J, Adams, J L, Lee, J C, Webb, E F, Carpenter, D C, Bochnowicz, S, Thomas, H C, Hay, D W, Griswold, D E

“…The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB…”
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A Novel Role for Tachykinin Neurokinin-3 Receptors in Regulation of Human Bronchial Ganglia Neurons by Myers, Allen C, Goldie, Roy G, Hay, Douglas W. P

“…The neuropeptide tachykinins and their receptors have been implicated in the pathogenesis of lung disease, although the role of the tachykinin neurokinin-3…”
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The effects of calcium channel inhibitors on twitches and noradrenaline contractions of the rat bisected vas deferens by Hay, D W, Wadsworth, R M

“…In the prostatic half of the rat vas deferens, responses to noradrenaline 30 microM were biphasic. Ca-deprivation reduced both phases. The initial part of the…”
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Cysteinyl leukotrienes in asthma: old mediators up to new tricks by Hay, Douglas W.P., Torphy, Theodore J., Undem, Bradley J.

“…The cysteinyl leukotrienes have long been suspected to play a role in the pathogenesis of asthma. This speculation was based largely on their release in human…”
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International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor by Brink, Charles, Dahlén, Sven-Erik, Drazen, Jeffrey, Evans, Jilly F, Hay, Douglas W P, Rovati, G Enrico, Serhan, Charles N, Shimizu, Takao, Yokomizo, Takehiko

“…Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are…”
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