Search Results - "Hay, D. L"

CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors? by Walker, C S, Hay, D L

“…The neuropeptide calcitonin gene‐related peptide (CGRP) is reported to play an important role in migraine. It is expressed throughout the trigeminovascular…”
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Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology by Watkins, H A, Walker, C S, Ly, K N, Bailey, R J, Barwell, J, Poyner, D R, Hay, D L

“…Background and Purpose Receptor activity‐modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor‐like receptor (CLR). The interactions of…”
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Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes by Bailey, RJ, Walker, CS, Ferner, AH, Loomes, KM, Prijic, G, Halim, A, Whiting, L, Phillips, ARJ, Hay, DL

“…BACKGROUND AND PURPOSE Amylin (Amy) is an important glucoregulatory peptide and AMY receptors are clinical targets for diabetes and obesity. Human (h) AMY…”
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Receptor activity‐modifying protein‐dependent impairment of calcitonin receptor splice variant Δ(1–47)hCT(a) function by Qi, T, Dong, M, Watkins, HA, Wootten, D, Miller, LJ, Hay, DL

“…Background and Purpose Alternative splicing expands proteome diversity to GPCRs. Distinct receptor variants have been identified for a secretin family GPCR,…”
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Oxyntomodulin Inhibits Food Intake in the Rat by Dakin, C. L, Gunn, I, Small, C. J, Edwards, C. M. B, Hay, D. L, Smith, D. M, Ghatei, M. A, Bloom, S. R

“…Oxyntomodulin is derived from proglucagon processing in the intestine and the central nervous system. To date, no role in the central nervous system has been…”
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Agonist‐dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor by Bailey, R J, Hay, D L

“…Background and purpose: Transmembrane proline (P) residues in family A G protein‐coupled receptors (GPCRs) form functionally important kinks in their helices…”
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Identification of key residues involved in adrenomedullin binding to the AM1 receptor by Watkins, HA, Au, M, Bobby, R, Archbold, JK, Abdul‐Manan, N, Moore, JM, Middleditch, MJ, Williams, GM, Brimble, MA, Dingley, AJ, Hay, DL

“…Background and Purpose Adrenomedullin (AM) is a peptide hormone whose receptors are members of the class B GPCR family. They comprise a heteromer between the…”
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WHAT MAKES A CGRP2 RECEPTOR? by Hay, DL

“…SUMMARY 1 Heterogeneity in the receptors for the neuropeptide calcitonin gene‐related peptide (CGRP) has been apparent for nearly 20 years. This is most…”
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PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells by Walker, C S, Sundrum, T, Hay, D L

“…Background and Purpose A major challenge in the development of new medicines targeting GPCRs is the ability to quantify drug action in physiologically relevant…”
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Amylin receptors: molecular composition and pharmacology by Hay, D L, Christopoulos, G, Christopoulos, A, Sexton, P M

“…Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin)…”
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CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin 22–52 , CGRP 8–37 and BIBN4096BS by Hay, D L, Howitt, S G, Conner, A C, Schindler, M, Smith, D M, Poyner, D R

“…Adrenomedullin (AM) has two known receptors formed by the calcitonin receptor‐like receptor (CL) and receptor activity‐modifying protein (RAMP) 2 or 3: We…”
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The pharmacology of CGRP-responsive receptors in cultured and transfected cells by Hay, D.L., Conner, A.C., Howitt, S.G., Takhshid, M.A., Simms, J., Mahmoud, K., Poyner, D.R.

“…Historically, CGRP receptors have been classified as CGRP 1 or CGRP 2 subtypes, chiefly depending on their affinity for the antagonist CGRP 8–37. It has been…”
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Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin by Conner, A C, Simms, J, Hay, D L, Mahmoud, K, Howitt, S G, Wheatley, M, Poyner, D R

“…RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors)…”
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Interaction of calcitonin-gene-related peptide with its receptors by Conner, A C, Hay, D L, Howitt, S G, Kilk, K, Langel, U, Wheatley, M, Smith, D M, Poyner, D R

“…The receptor for calcitonin-gene-related peptide (CGRP) is a heterodimer formed by calcitonin-receptor-like receptor (CRLR), a type II (family B)…”
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Mapping the CGRP receptor ligand binding domain: Tryptophan-84 of RAMP1 is critical for agonist and antagonist binding by Moore, E.L., Gingell, J.J., Kane, S.A., Hay, D.L., Salvatore, C.A.

“…The calcitonin receptor-like receptor (CLR) associates with the accessory protein RAMP1 to form a receptor for the neuropeptide calcitonin gene-related peptide…”
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CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22–52, CGRP8–37 and BIBN4096BS by Hay, D L, Howitt, S G, Conner, A C, Schindler, M, Smith, D M, Poyner, D R

“…Adrenomedullin (AM) has two known receptors formed by the calcitonin receptor‐like receptor (CL) and receptor activity‐modifying protein (RAMP) 2 or 3: We…”
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Adrenomedullin: receptor and signal transduction by Smith, D M, Coppock, H A, Withers, D J, Owji, A A, Hay, D L, Choksi, T P, Chakravarty, P, Legon, S, Poyner, D R

“…Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin, calcitonin-gene-related peptide…”
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Effects of Melanocortin Receptor Ligands on Thyrotropin-Releasing Hormone Release: Evidence for the Differential Roles of Melanocortin 3 and 4 Receptors by Kim, M. S., Small, C. J., Russell, S. H., Morgan, D. G. A., Abbott, C. R., AlAhmed, S. H., Hay, D. L., Ghatei, M. A., Smith, D. M., Bloom, S. R.

“…The hypothalamic melanocortin system is important in the central regulation of food intake and body weight. We have previously demonstrated that…”
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Oxyntomodulin inhibits food intake in the rat by Dakin, C L, Gunn, I, Small, C J, Edwards, C M, Hay, D L, Smith, D M, Ghatei, M A, Bloom, S R

“…Oxyntomodulin is derived from proglucagon processing in the intestine and the central nervous system. To date, no role in the central nervous system has been…”
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Placental histology and the production of human choriogonadotrophin and its subunits in pregnancy by Hay, D L

“…The relation between placental histology and the levels of human chorionic gonadotrophin (hCG) and its alpha-hCG and beta-hCG subunits was studied using…”
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