Search Results - "Hay, Ariel M."

Co-transfection of murine NXPE2 and murine glycophorin A confers reactivity with Ter-119 by Keele, Gregory R, Hay, Ariel M, Holness, Nadia K, Jash, Arijita, Ewald, Sarah E, O'Connor, Callan, Vincent, Matthew, Dzieciatkowska, Monika, D'Alessandro, Angelo, Churchill, Gary A, Zimring, James C

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Identification of multiple genetic loci associated with red blood cell alloimmunization in mice by Jash, Arijita, Howie, Heather L, Hay, Ariel M, Luckey, Chance John, Hudson, Krystalyn E, Thomson, Peter C, Ratcliffe, Sarah J, Smolkin, Mark, Zimring, James C

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Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice by Howie, Heather L., Hay, Ariel M., de Wolski, Karen, Waterman, Hayley, Lebedev, Jenna, Fu, Xiaoyun, Culp-Hill, Rachel, D'Alessandro, Angelo, Gorham, James D., Ranson, Matthew S., Roback, John D., Thomson, Peter C., Zimring, James C.

“…Red blood cells (RBCs) are the most numerous cell type in the body and serve a vital purpose of delivering oxygen to essentially all tissues. In addition to…”
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IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice by Shinde, Paurvi, Howie, Heather L, Stegmann, Tamara C, Hay, Ariel M, Waterman, Hayley R, Szittner, Zoltan, Bentlage, Arthur E H, Kapp, Linda, Lissenberg-Thunnissen, Suzanne N, Dekkers, Gillian, Schasfoort, Richard B M, Ratcliffe, Sarah J, Smolkin, Mark E, Vidarsson, Gestur, van der Schoot, C Ellen, Hudson, Krystalyn E, Zimring, James C

“…It has long been appreciated that immunoglobulins are not just the effector endpoint of humoral immunity, but rather have a complex role in regulating antibody…”
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Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice by D'Alessandro, Angelo, Howie, Heather L, Hay, Ariel M, Dziewulska, Karolina H, Brown, Benjamin C, Wither, Matthew J, Karafin, Matthew, Stone, Elizabeth F, Spitalnik, Steven L, Hod, Eldad A, Francis, Richard O, Fu, Xiaoyun, Thomas, Tiffany, Zimring, James C

“…Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (approximately 5%)…”
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Molecular communication between red blood cells of different phenotypes during blood storage in mice by Zimring, James C., Hay, Ariel M., Dzieciatkowska, Monika, D'Alessandro, Angelo

“…Background The cellular and molecular changes during red blood cell (RBC) storage that affect posttransfusion recovery (PTR) remain incompletely understood. We…”
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Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model by Dziewulska, Karolina H, Reisz, Julie A, Hay, Ariel M, D'Alessandro, Angelo, Zimring, James C

“…Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans (~5% of all individuals). G6PD deficiency (G6PDd) is caused by an…”
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Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice by Jash, Arijita, Pridmore, Thomas, Collins, James B, Hay, Ariel M, Hudson, Krystalyn E, Luckey, Chance John, Zimring, James C

“…Administration of anti-RhD immunoglobulin (Ig) to decrease maternal alloimmunization (antibody-mediated immune suppression [AMIS]) was a landmark clinical…”
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Mouse background genetics in biomedical research: The devil's in the details by Hay, Ariel M., Howie, Heather L., Gorham, James D., D'Alessandro, Angelo, Spitalnik, Steven L., Hudson, Krystalyn E., Zimring, James C.

“…Background Genetically modified mice are used widely to explore mechanisms in most biomedical fields—including transfusion. Concluding that a gene modification…”
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Complement activation on endothelium initiates antibody-mediated acute lung injury by Cleary, Simon J, Kwaan, Nicholas, Tian, Jennifer J, Calabrese, Daniel R, Mallavia, Beñat, Magnen, Mélia, Greenland, John R, Urisman, Anatoly, Singer, Jonathan P, Hays, Steven R, Kukreja, Jasleen, Hay, Ariel M, Howie, Heather L, Toy, Pearl, Lowell, Clifford A, Morrell, Craig N, Zimring, James C, Looney, Mark R

“…Antibodies targeting human leukocyte antigen (HLA)/major histocompatibility complex (MHC) proteins limit successful transplantation and transfusion, and their…”
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Impact of taurine on red blood cell metabolism and implications for blood storage by Bertolone, Lorenzo, Roy, Micaela Kalani, Hay, Ariel M., Morrison, Evan J., Stefanoni, Davide, Fu, Xiaoyun, Kanias, Tamir, Kleinman, Steve, Dumont, Larry J., Stone, Mars, Nemkov, Travis, Busch, Michael P., Zimring, James C., D'Alessandro, Angelo

“…ABSTRACT BACKGROUND Taurine is an antioxidant that is abundant in some common energy drinks. Here we hypothesized that the antioxidant activity of taurine in…”
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The role of RBC antigen transgene integration sites on RBC biology in mice by Jash, Arijita, Hay, Ariel M., Collins, J. Baodan, Heo, Jinho, Luckey, Chance John, Hudson, Krystalyn E., Zimring, James C.

“…Background Transgenic mice expressing RBC specific antigens are widely used in mechanistic studies of RBC alloimmunization. Existing RBC donor strains have…”
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Primaquine-5,6-Orthoquinone Is Directly Hemolytic to Older G6PD Deficient RBCs in a Humanized Mouse Model by Dziewulska-Cronk, Karolina H, Reisz, Julie A, Hay, Ariel M, Nemkov, Travis, Cendali, Francesca I, Issaian, Aaron, Lamb, Derek R, Palha, Mitasha S, Legenzov, Eric A, Kao, Joseph P Y, Walker, Larry A, Tekwani, Babu L, Buehler, Paul W, D'Alessandro, Angelo, Zimring, James C

“…Primaquine and Tafenoquine are the only approved drugs that can achieve a radical cure for malaria but are contraindicated in patients who are deficient in…”
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In utero exposure to alloantigens primes alloimmunization to platelet transfusion in mice by Poston, Jacqueline N., Jash, Arijita, Hannan, Lindsay M., Hay, Ariel M., Usaneerungrueng, Chomkan, Howie, Heather L., Kapp, Linda M., Zimring, James C.

“…Background Platelet transfusions remain a mainstay of treatment for many patients with thrombocytopenia, but can lead to alloantibodies to Human Leukocyte…”
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Increased exercise tolerance in humanized G6PD deficient mice by Cendali, Francesca I, Lisk, Christina, Dzieciatkowska, Monika, LaCroix, Ian S, Reisz, Julie A., Harral, Julie, Stephenson, Daniel, Hay, Ariel M, Wartchow, Eric, Darehshouri, Anza, Dziewulska, Karolina, Buehler, Paul W, Norris, Philip J, Deng, Xutao, Busch, Michael P., Earley, Eric J, Page, Grier P, Hansen, Kirk C, Zimring, James C, Irwin, David, Nemkov, Travis, D'Alessandro, Angelo

“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 500 million people globally, impacting red blood cell (RBC) antioxidant pathways and increasing…”
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Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice by Gruber, David R., Richards, Amanda L., Howie, Heather L., Hay, Ariel M., Lebedev, Jenna N., Wang, Xiaohong, Zimring, James C., Hudson, Krystalyn E.

“…Antibodies are typically thought of as the endpoint of humoral immunity that occur as the result of an adaptive immune response. However, affinity-matured…”
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Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues by Cole, Toby B, Li, Wan-Fen, Co, Aila L, Hay, Ariel M, MacDonald, James W, Bammler, Theo K, Farin, Federico M, Costa, Lucio G, Furlong, Clement E

“…Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents…”
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Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice by Jash, Arijita, Pridmore, Thomas, Collins, James B, Hay, Ariel M, Hudson, Krystalyn E, Luckey, Chance John, Zimring, James C

“…Administration of anti-RhD immunoglobulin (Ig) to decrease maternal alloimmunization (antibody-mediated immune suppression [AMIS]) was a landmark clinical…”
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Biliverdin Reductase B Protects Against Primaquine Induced Hemolysis - Identification of a Novel Anti-Oxidant Pathway in Murine Erythrocytes by Dziewulska-Cronk, Karolina, Hay, Ariel M, D'Alessandro, Angelo, Reisz, Julie A, Garrett, Jordan, Buehler, Paul, Kao, Joseph, Zimring, James C

“…Background: Biliverdin Reductase B (BlvrB) is the fourth most abundant enzyme in red blood cells (RBCs) and is widely expressed in other tissues. In normal…”
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NXPE2 Is the Target of Ter-119 When Complexed with Gypa in Mice by Keele, Gregory R, Holness, Nadia, Jash, Arijita, Hay, Ariel M, Ewald, Sarah, Churchill, Gary A, D'Alessandro, Angelo, Dzieciatkowska, Monika, Zimring, James C

“…Background: Red blood cells (RBCs) have a complex biology that allows regulation of metabolism, cellular rigidity, ion exchange, pH, and molecular…”
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