Search Results - "Hay, Alayna N."

Tumor-derived extracellular vesicles disrupt the blood–brain barrier endothelium following high-frequency irreversible electroporation by Murphy, Kelsey R., Aycock, Kenneth N., Marsh, Spencer, Hay, Alayna N., Athanasiadi, Ilektra, Bracha, Shay, Chang, Christine, Gourdie, Robert, Davalos, Rafael V., Rossmeisl, John H., Dervisis, Nikolaos G.

“…High-frequency irreversible electroporation (H-FIRE), a nonthermal brain tumor ablation therapeutic, generates a central tumor ablation zone while transiently…”
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A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments by Hay, Alayna N, Ruger, Lauren, Hsueh, Andy, Vickers, Elliana, Klahn, Shawna, Vlaisavljevich, Eli, Tuohy, Joanne

“…Cancer is a devasting disease resulting in millions of deaths worldwide in both humans and companion animals, including dogs. Treatment of cancer is complex…”
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High intensity focused ultrasound for the treatment of solid tumors: a pilot study in canine cancer patients by Carroll, Jennifer, Coutermarsh-Ott, Sheryl, Klahn, Shawna L., Tuohy, Joanne, Barry, Sabrina L., Allen, Irving C., Hay, Alayna N., Ruth, Jeffrey, Dervisis, Nick

“…To investigate the safety, feasibility, and outcomes of High-Intensity Focused Ultrasound (HIFU) for the treatment of solid tumors in a spontaneous canine…”
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Investigating cell death responses associated with histotripsy ablation of canine osteosarcoma by Hay, Alayna N, Vickers, Elliana R, Patwardhan, Manali, Gannon, Jessica, Ruger, Lauren, Allen, Irving C, Vlaisavljevich, Eli, Tuohy, Joanne

“…Osteosarcoma (OS) is the most frequently occurring primary bone tumor in dogs and people and innovative treatment options are profoundly needed. Histotripsy is…”
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Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus by Zhu, Jing, Hay, Alayna N, Potter, Ashley A, Richwine, Madison W, Sproule, Thomas, LeRoith, Tanya, Wilson, John, Hasham, Muneer G, Roopenian, Derry C, Leeth, Caroline M

“…Almost a decade has passed since the approval of belimumab, an mAb directed against B lymphocyte stimulation and the first targeted therapy approved for…”
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Ablative and Immunostimulatory Effects of Histotripsy Ablation in a Murine Osteosarcoma Model by Hay, Alayna N, Imran, Khan Mohammad, Hendricks-Wenger, Alissa, Gannon, Jessica M, Sereno, Jacqueline, Simon, Alex, Lopez, Victor A, Coutermarsh-Ott, Sheryl, Vlaisavljevich, Eli, Allen, Irving C, Tuohy, Joanne L

“…: Osteosarcoma (OS) is the most frequently occurring malignant bone tumor in humans, primarily affecting children and adolescents. Significant advancements in…”
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Investigation of High Frequency Irreversible Electroporation for Canine Spontaneous Primary Lung Tumor Ablation by Hay, Alayna N, Aycock, Kenneth N, Lorenzo, Melvin F, David, Kailee, Coutermarsh-Ott, Sheryl, Salameh, Zaid, Campelo, Sabrina N, Arroyo, Julio P, Ciepluch, Brittany, Daniel, Gregory, Davalos, Rafael V, Tuohy, Joanne

“…In this study, the feasibility of treating canine primary lung tumors with high-frequency irreversible electroporation (H-FIRE) was investigated as a novel…”
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Use of Genome Editing Techniques to Produce Transgenic Farm Animals by Hay, Alayna N, Farrell, Kayla, Leeth, Caroline M, Lee, Kiho

“…Recombinant proteins are essential for the treatment and diagnosis of clinical human ailments. The availability and biological activity of recombinant proteins…”
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Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors by Arnold, Lauren, Hendricks-Wenger, Alissa, Coutermarsh-Ott, Sheryl, Gannon, Jessica, Hay, Alayna N., Dervisis, Nikolaos, Klahn, Shawna, Allen, Irving C., Tuohy, Joanne, Vlaisavljevich, Eli

“…Osteosarcoma (OS) is a primary bone tumor affecting both dogs and humans. Histotripsy is a non-thermal, non-invasive focused ultrasound method using controlled…”
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Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors by Ruger, Lauren N., Hay, Alayna N., Gannon, Jessica M., Sheppard, Hannah O., Coutermarsh-Ott, Sheryl L., Daniel, Gregory B., Kierski, Katharine R., Ciepluch, Brittany J., Vlaisavljevich, Eli, Tuohy, Joanne L.

“…Objective: Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with limited non-surgical treatment options. As the first completely…”
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Interferon gamma protective against Sarcocystis neurona encephalitis in susceptible murine model by Hay, Alayna N., Potter, Ashley, Lindsay, David, LeRoith, Tanya, Zhu, Jing, Cashwell, Sarah, Witonsky, Sharon, Leeth, Caroline

“…•Strain background contributes to disease susceptibility of Scid knockout mice to Sarcocytsis neurona encephalitis.•Interferon gamma derived from T cells is…”
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High-frequency irreversible electroporation brain tumor ablation: exploring the dynamics of cell death and recovery by Murphy, Kelsey R., Aycock, Kenneth N., Hay, Alayna N., Rossmeisl, John H., Davalos, Rafael V., Dervisis, Nikolaos G.

“…•H-FIRE induces dose dependent permeability, apoptosis, and metabolic dysfunction.•Select H-FIRE doses permit tumor cell damage recovery, allowing for…”
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Corrigendum to ‘Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors’ [Ultrasound in Med & Biol. 47 (2021) 3435-3446] by Arnold, Lauren, Hendricks-Wenger, Alissa, Coutermarsh-Ott, Sheryl, Gannon, Jessica, Hay, Alayna N., Dervisis, Nikolaos, Klahn, Shawna, Allen, Irving C., Tuohy, Joanne, Vlaisavljevich, Eli

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RAPID COMMUNICATION: TLR4 expressed but with reduced functionality on equine B lymphocytes by Hay, Alayna N, Potter, Ashley, Kasmark, Leah, Zhu, Jing, Leeth, Caroline M

“…Abstract Varying susceptibility exists among mammalian species to the development of potentially fatal endotoxemia due to gram-negative bacteria molecular…”
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Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors In Vivo by Ruger, Lauren N, Hay, Alayna N, Gannon, Jessica M, Sheppard, Hannah O, Coutermarsh-Ott, Sheryl L, Daniel, Gregory B, Kierski, Katharine R, Ciepluch, Brittany J, Vlaisavljevich, Eli, Tuohy, Joanne L

“…Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with limited non-surgical treatment options. As the first completely non-invasive and…”
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Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs by Ruger, Lauren N, Hay, Alayna N, Vickers, Elliana R, Coutermarsh-Ott, Sheryl L, Gannon, Jessica M, Covell, Hannah S, Daniel, Gregory B, Laeseke, Paul F, Ziemlewicz, Timothy J, Kierski, Katharine R, Ciepluch, Brittany J, Vlaisavljevich, Eli, Tuohy, Joanne L

“…Osteosarcoma (OS) is a malignant bone tumor treated by limb amputation or limb salvage surgeries and chemotherapy. Histotripsy is a non-thermal, non-invasive…”
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Horses affected by EPM have increased sCD14 compared to healthy horses by Hay, Alayna N., Wagner, Bettina, Leeth, Caroline M., LeRoith, Tanya, Cecere, Thomas E., Lahmers, Kevin K., Andrews, Frank M., Werre, Stephen R., Johnson, Amy L., Clark, Carol K., Pusterla, Nicola, Reed, Stephen M., Lindsay, David S., Taylor, Sandra, Estell, Krista E., Furr, Martin, MacKay, Robert J., Del Piero, Fabio, Witonsky, Sharon G.

“…•Serum and CSF samples were analyzed for the proinflammatory marker soluble CD14 (sCD14).•Circulating serum and CSF sCD14 concentrations differed between EPM…”
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Sarcocystis neurona–Induced Myeloencephalitis Relapse Following Anticoccidial Treatment by Hay, Alayna N, Witonsky, Sharon G, Lindsay, David S, LeRoith, Tanya, Zhu, Jing, Kasmark, Leah, Leeth, Caroline M

“…Sarcocystis neurona is a ubiquitous parasite in the eastern United States, which is the principal causative agent in the neurologic disorder equine protozoal…”
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Abrogated AID function prolongs survival and diminishes renal pathology in the BXSB mouse model of SLE by Zhu, Jing, Hay, Alayna N, Potter, Ashley A, Richwine, Madison W, Sproule, Thomas, LeRoith, Tanya, Wilson, John, Hasham, Muneer G, Roopenian, Derry C, Leeth, Caroline M

“…Almost a decade has passed since the approval of belimumab, a monoclonal antibody directed against B lymphocyte stimulation and the first targeted therapy…”
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Abstract A030: Investigating the feasibility of in-vivo histotripsy ablation for osteosarcoma using an orthotopic murine model and a canine model of spontaneous disease by Hay, Alayna N., Ruger, Lauren, Hixson, Haleigh, Gannon, Jessica, Simon, Alex, Sheppard, Hannah, Coutermarsh-Ott, Sheryl, Davis, Elaina, Kierski, Katharine, Ciepluch, Brittany, Neufeld, Nathan, Vlaisavljevich, Eli, Tuohy, Joanne

“…Osteosarcoma (OS) is the most commonly occurring primary bone tumor in pediatric cancer patients and dogs, with estimated incidences of 3-4 cases per 1 million…”
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