Search Results - "Hay, Alasdair"

Reducing ventilator-associated pneumonia in intensive care: Impact of implementing a care bundle by Morris, Andrew Conway, Hay, Alasdair W, Swann, David G, Everingham, Kirsty, McCulloch, Corrienne, McNulty, Jane, Brooks, Odette, Laurenson, Ian F, Cook, Brian, Walsh, Timothy S

“…OBJECTIVES:Ventilator-associated pneumonia is the most common intensive care unit-acquired infection. Although there is widespread consensus that…”
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C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients by Morris, Andrew Conway, Brittan, Mairi, Wilkinson, Thomas S., McAuley, Danny F., Antonelli, Jean, McCulloch, Corrienne, Barr, Laura C., McDonald, Neil A., Dhaliwal, Kev, Jones, Richard O., Mackellar, Annie, Haslett, Christopher, Hay, Alasdair W., Swann, David G., Anderson, Niall, Laurenson, Ian F., Davidson, Donald J., Rossi, Adriano G., Walsh, Timothy S., Simpson, A. John

“…Critically ill patients are at heightened risk for nosocomial infections. The anaphylatoxin C5a impairs phagocytosis by neutrophils. However, the mechanisms by…”
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Early lactate clearance in septic patients with elevated lactate levels admitted from the emergency department to intensive care: Time to aim higher? by Walker, Craig A., MB, ChB, FCEM, Griffith, David M., MB, ChB, FRCA, Gray, Alasdair J., MB, ChB, MD, FRCS, FCEM, Datta, Deepankar, MB, ChB, BSc(Hons), Hay, Alasdair W., MB, ChB, FRCA, DICM, MSc

“…Abstract Purpose Septic patients with hyperlactatemia have increased mortality rates, irrespective of hemodynamic and oxygen-derived variables. The aims of the…”
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Is the combination of UV-C light and bleach less effective than bleach alone for intensive care unit surface disinfection? by Shek Daud, Nur Shazlin, Dunn, Mark, Moncayo-Nieto, Olga Lucia, Hay, Alasdair

“…Chlorine-based disinfectants, such as bleach, are commonly used for cleaning in healthcare settings to prevent the transmission of nosocomial pathogens. To…”
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Patients with hip fracture admitted to critical care: Epidemiology, interventions and outcome by Gibson, Alistair A, Hay, Alasdair W, Ray, David C

“…Abstract Introduction Although there is much current debate about the use of critical care to enhance peri-operative care of patients with hip fracture there…”
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“Lactate Shift,” Rather Than “Lactate Clearance,” for Serial Blood Lactate Monitoring? by Walker, Craig A, Griffith, David M, Gray, Alasdair J, Datta, Deepankar, Hay, Alasdair W

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Information technology to improve patient safety: A round table discussion from the 5th International Patient Safety Forum, Riyadh, Saudi Arabia, April 14-16, 2015 by Arabi, Yaseen, Pickering, Brian, Al-Dorzi, Hasan, Alsaawi, Abdulmohsen, Al-Qahtani, Saad, Hay, Alasdair

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Induction drug and outcome of patients admitted to the intensive care unit after emergency laparotomy by Ray, David C, Hay, Alasdair W, McKeown, Dermot W

“…BACKGROUND AND OBJECTIVEEtomidate is often used to induce anaesthesia in sick patients owing to its relative cardiovascular stability. However, etomidate…”
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Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial by Abdulakeem, Ajibode, Acosta, Andres, Aziz, N, Badhan, Gurpreet R, Banerjee, Ritwik, Baral, Ananya M, Bawa, Fareha, Bennett, Lorraine, Beresford, Matthew, Brearey, Stephen, Cabandugama, Amanda, Cannons, Vivienne, Carter, Jonathan, Chin, KokWai, Clark, James, Clark, Kaylea, Clarke, Roseanne, Colley, Julie, Crichton, Charles, Currie, Craig, Duric, Natalie, Farrell, Barbara, Fenton, Melisa, Flanagan, Michael, Flynn, Rachel, Fung, Carrie, Garner, Lucie, Gedge, Ian, Gibson, Bethan, Gogoi, Sukanya, Goyal, Sunil, Grieg, Natasha, Gunganah, Kirun, Gureviciute, Alvyda, Harvala, Heli, Hazenberg, Phoebe, Hector, Gemma, Heys, Joseph, Holmes, Rebecca, Ingle, Tejas, Iqbal Sait, Faisal, Jenkin, Ifan, Johnstone, Dawn, Kapil, Vikas, Kingsmore, Laura, Lason, Wojciech, Latham, Victoria, Lee, Shi Han, Lees, Diana, Llewelyn, Martin, Lloyd, Aaron, Looby, Laura, Luke, H, Madziva, Lorraine, Mallinder, Petrina, Martin, Winston, Masood, Mohammad T, McKenna, Shirley, McNelis, Una, Medveczky, Thomas, Metherell, Stella, Mihalca-Mason, Loredana, Moyo, Quberkani, Nair, Rajiv, Nethercott, Daniel, Noori, Zaid, Osanlou, Rostam, Parfitt, Louise, Peirce, Benjamin H, Pereira, Rita, Plumptre, Charles, Potter, Jean, Ratcliff, Simbisai, Rehman, Zainab, Rizvi, Syed AS, Roberts, Nicky, Rowley, Megan, Sanderson, Amy, Sellick, Victoria, Shortman, Rob, Smith, Chris, Smith, Sally, Stratton, Emma, Stuttard, Matt, Tamblin-Hopper, Phoebe, Taylor, Margaret, Thomas, Caradog, Umeadi, Judith, Veli, Neyme, Vernon, Britney, Wakefield, Alice, Weinreich, David M, West, Ruth, Wignall, Christopher, Wills, Louise, Winder, Piers, Winslow, Helen, Worley, Daniel, Ylquimiche, Laura, Yu, Chrissie

“…Casirivimab and imdevimab are non-competing monoclonal antibodies that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike…”
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Whole-genome sequencing reveals host factors underlying critical COVID-19 by Kousathanas, Athanasios, Pairo-Castineira, Erola, Rawlik, Konrad, Stuckey, Alex, Odhams, Christopher A., Walker, Susan, Russell, Clark D., Malinauskas, Tomas, Wu, Yang, Millar, Jonathan, Shen, Xia, Elliott, Katherine S., Griffiths, Fiona, Oosthuyzen, Wilna, Morrice, Kirstie, Keating, Sean, Wang, Bo, Rhodes, Daniel, Klaric, Lucija, Zechner, Marie, Parkinson, Nick, Siddiq, Afshan, Goddard, Peter, Donovan, Sally, Maslove, David, Nichol, Alistair, Semple, Malcolm G., Zainy, Tala, Maleady-Crowe, Fiona, Todd, Linda, Salehi, Shahla, Knight, Julian, Elgar, Greg, Chan, Georgia, Arumugam, Prabhu, Patch, Christine, Rendon, Augusto, Bentley, David, Kingsley, Clare, Kosmicki, Jack A., Horowitz, Julie E., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A. R., Justice, Anne, Mirshahi, Tooraj, Oetjens, Matthew, Rader, Daniel J., Ritchie, Marylyn D., Verma, Anurag, Fowler, Tom A., Shankar-Hari, Manu, Summers, Charlotte, Hinds, Charles, Horby, Peter, Ling, Lowell, McAuley, Danny, Montgomery, Hugh, Openshaw, Peter J. M., Elliott, Paul, Walsh, Timothy, Tenesa, Albert, Fawkes, Angie, Murphy, Lee, Rowan, Kathy, Ponting, Chris P., Vitart, Veronique, Wilson, James F., Yang, Jian, Bretherick, Andrew D., Scott, Richard H., Hendry, Sara Clohisey, Moutsianas, Loukas, Law, Andy, Caulfield, Mark J., Baillie, J. Kenneth

“…Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1…”
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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 by Pairo-Castineira, Erola, Rawlik, Konrad, Bretherick, Andrew D., Qi, Ting, Wu, Yang, Nassiri, Isar, McConkey, Glenn A., Zechner, Marie, Klaric, Lucija, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Richmond, Anne, Millar, Jonathan, Russell, Clark D., Malinauskas, Tomas, Thwaites, Ryan, Morrice, Kirstie, Keating, Sean, Maslove, David, Nichol, Alistair, Semple, Malcolm G., Knight, Julian, Shankar-Hari, Manu, Summers, Charlotte, Hinds, Charles, Horby, Peter, Ling, Lowell, McAuley, Danny, Montgomery, Hugh, Openshaw, Peter J. M., Begg, Colin, Walsh, Timothy, Tenesa, Albert, Flores, Carlos, Riancho, José A., Rojas-Martinez, Augusto, Lapunzina, Pablo, Yang, Jian, Ponting, Chris P., Wilson, James F., Vitart, Veronique, Abedalthagafi, Malak, Luchessi, Andre D., Parra, Esteban J., Cruz, Raquel, Carracedo, Angel, Fawkes, Angie, Murphy, Lee, Rowan, Kathy, Pereira, Alexandre C., Law, Andy, Fairfax, Benjamin, Hendry, Sara Clohisey, Baillie, J. Kenneth

“…Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of…”
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A second update on mapping the human genetic architecture of COVID-19 by Jansen, Philip, Nakanishi, Tomoko, Priest, James, Turebayeva, Gulsimzhan, Bouab, Meriem, Bourque, Guillaume, Tse, Sze Man, Faucon, Annika B, Jensen, Björn-Erik Ole, Bals, Robert, Noor, Abdul, Liontos, Angelos, Azuure, Clinton, Blanco-Grau, Albert, Casalone, Elisabetta, Bellelli, Giuseppe, Kurihara, Hayato, Farré, Xavier, Hunkapiller, Julie, Kim, Jin Yong, Lee, Ji Yeon, Jung, Keum Ji, Bretherick, Andrew D, Ostermann, Marlies, Ryan, Lucy, Briton, Kate, Cutler, Sean, Springle, Philippa, Goodwin, Emma, Tibke, Clare, Farley, Sean, Bradley-Potts, Joanne, Whileman, Amanda, Kaye, Callum, Preston, Stephen, Cupitt, Jason, Jakkula, Srinivas, Lamb, Thomas, Hudson, Anne, Clark, Richard, Hudig, Lisa, Roberts, Abigail, Slevin, Kathryn, Thomas, Vicky, Chisholm, Catherine, Scanlon, Jeremy, Jones, Helen, Riches, Joanne, Anderson, Susan, Davies, Rhys, Tebbutt, Julie, Conyngham, Jo-Anna, Hobden, Gillian, Collier, Dawn, Durga, Latha, Wilson, Alison, Finnell, Jez, Serrano-Ruiz, Alfredo, Turner, Patricia, Turney, Sharon, Tutt, Gabriella, Varghese, Mathew, Stuart, Carmel, Wood, Stephen, Cother, Naiara, Brady, Ailbhe, Arden, Tracie, Capps, Nigel, Lennon, Liz, Joseph, Sibet, Jennings, Claire, Revill, Adam, Fletcher, Jo, Sutherland, Isobel, Kaye, Duncan, Whitbread, Jennifer, Hector, Gemma, Goddard, Peter, Lauder, Christen, Oosthuyzen, Wilna, Szoor-Mcelhinney, Helen, Upadhyay, Kamlesh J, Joshi, Chaitanya G, Kabata, Hiroki, Mikami, Yohei, Sonobe, Kazunari, Tateno, Hiroki, Yoshihara, Tomoyuki, Kuwahara, Naota, Sugiura, Hisatoshi, Ishihara, Sayoko, Ismail, Said I, Feng, Yen-Chen Anne, Castano, Luis, Ceballos, Francisco C, Aguado, Jose María, Carbonell, Cristina, Werge, Thomas, Wilson, Daniel J, Serra-Llovich, Alex

“…In total, 15 out of 51 loci could be linked to three major pathways involved in susceptibility and severity defined by expert-driven classification…”
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Use PROSEVA study criteria not COVID-19 phenotype to guide proning treatment decisions by Craven, Thomas H, Young, Neil, Keating, Seán, Livesey, John Andrew, Hay, Alasdair

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Neurological outcome following out of hospital cardiac arrest: Evaluation of performance of existing risk prediction models in a UK cohort by Livesey, John A, Lone, Nazir, Black, Emily, Broome, Richard, Syme, Alastair, Keating, Sean, Elliott, Laura, McCahill, Cara, Simpson, Gavin, Grant, Helen, Auld, Fiona, Garrioch, Sweyn, Hay, Alasdair, Craven, Thomas H

“…Introduction: Out of hospital cardiac arrest (OHCA) is a common problem. Rates of survival are low and a proportion of survivors are left with an unfavourable…”
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Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients by Abbott, T.E.F., Minto, G., Lee, A.M., Pearse, R.M., Ackland, G.L.

“…Elevated preoperative heart rate (HR) is associated with perioperative myocardial injury and death. In apparently healthy individuals, high resting HR is…”
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Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units by Kydonaki, Kalliopi, Hanley, Janet, Huby, Guro, Antonelli, Jean, Walsh, Timothy Simon

“…ObjectivesVarious strategies to promote light sedation are highly recommended in recent guidelines, as deep sedation is associated with suboptimum patient…”
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Stratified analyses refine association between TLR7 rare variants and severe COVID-19 by Millar, Johnny, Pereira, Alexandre C., Aravindan, Latha, Das, Sukamal, Fourman, Max Head, Golightly, Ailsa, Law, Dawn, Law, Sarah, Murphy, Sheena, Ward, Mairi, Arbane, Gill, Xavier, Kugan, Banach, Dorota, Hutton, Paula, Barclay, Lucy, Peasgood, Emily, Ezeobu, Obiageri, Da Gloria, Edna Fernandes, Kent, Alissa, Bamford, Peter, Dykes, Joseph, Hijazi, Muhammad, Thomas, Jacqueline, Fine, Christopher, Ali, Syamlan, Gibson, Sian, McNeela, Fiona, Krishnamurthy, Vinodh, Trotman, Sallyanne, Cabrelli, Louise, Butler, Aaron, Gardner, Amy, Davis, Caroline, Durie, Alison, Morgan, Aled, Purewal, Manjit, Walton, Olivia, Ward, Luke, Thomson, Nicola, Savill, Heather, Bhatia, Nikhil, Webster, Andrea, Anderson, Felicity, Harvey, Alice, Poulaka, Maria, Baxter, Nicola, Akeroyd, Louise, Hudig, Lisa, Jones, Cathy, Pritchard, Kelly, Butcher, Deborah, Rowland-Jones, Sarah, Pinnell, Jez, Hibbert, Meg, Branney, Debbie, Ma, Louise, Parmar, Chetan, Jose, Sanal, Mahenthran, Mervin, Creagh-Brown, Ben, Mayangao, Irving, Marriott, Cheryl, Hierons, Sarah, Howie, Lucy, Ramos, Lidia, Menzies, Daniel, Davies, Llinos, Coton, Zoe, Vedage, Dave, Morrison, Alan, Symon, Lesley, Kannan, Thogulava, Barron, Anthony, Mitra, Atideb, Pollard, Rachel, Stead, Rachael, Skinner, Denise, Crickmore, Vikki, Deery, Joanne, Turki, Salah, Tutton, Rebecca, Waldron, Joanne, Rekha, Patel, King, Bernadette, Tyl, David, Johnson, Laura, Little, Jeff, McParland, Chantal, George, Linsha, Lewis, Tracy, Saunderson, Paula, Thornton, Lorraine, Allibone, Suzanne, Fagan, Andrew, Thomas, Helen, Jackson, Peter, Carter, Sasha, Hall, Kathryn, Hardy, John, Rawlik, Konrad

“…Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to…”
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Information technology to improve patient safety: A round table discussion from the 5(th) International Patient Safety Forum, Riyadh, Saudi Arabia, April 14-16, 2015 by Arabi, Yaseen M, Pickering, Brian W, Al-Dorzi, Hasan M, Alsaawi, Abdulmohsen, Al-Qahtani, Saad M, Hay, Alasdair W

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Information technology to improve patient safety: A round table discussion from the 5 th International Patient Safety Forum, Riyadh, Saudi Arabia, April 14–16, 2015 by Arabi, Yaseen, Pickering, Brian, Al-Dorzi, Hasan, Alsaawi, Abdulmohsen, Al-Qahtani, Saad, Hay, Alasdair

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Transfer of Adults between Intensive Care Units in the Unitied Kingdom: Clinical Practice by Hay, Alasdair, Smith, Robyn, Hilditch, Graham, Wallace, Peter GM

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